The Big & Dandy Methoxetamine Thread-11th Dose-50 grams and a kidney later..

[psood0nym]

^... huh, yeah that makes sense. REALLY should've read your post fist, heh.

 

[TheAppleCore]

Affininity can result in different responses depending on the properties of a drug, and is different from efficacy. This is an oversimplification, but basically if a drug has affinity for the serotonin transporter protein (SERT) but has no efficacy it's an antagonist (it just sits their getting in the way of other drugs like MDMA or natural neurotransmitters like serotonin). For example, the SERT inhibitor duloxetine mitigates the effects of MDMA, which partially works by reversing the action of SERT i.e. releases serotonin (also, don't confuse SERT, the serotonin pump, with 5HTx binding sites, as they're different things). That's what's confusing me about the segment of the paper posted. The authors talk of MXE both having affinity for and "inhibiting" the serotonin transporter protein, which sounds like antagonism (basically it plugs up the pump [SERT] that takes serotonin back into the neuron), but then go on to suggest there is a resulting increase in the release of serotonin (which sounds like a drug that reverses the activity of the protein, thereby pumping serotonin out instead of in). But I wouldn't expect that the release of serotonin would increase (it would just keep releasing normally but reuptake would be slowed because the transporter proteins are inhibited by MXE). In other words, it seems like inhibiting SERT should increase intracellular serotonin but not cause increased release, yet they seem to suggest MXE may cause increased release of serotonin despite this.

Thanks a lot man, makes sense.

 

[Transform]

The UK government have published the draft for an amendment of the misuse of drugs act, adding some newly emerged drugs in as recommended by the advisory council on the misuse of drugs last year. You can read their explanation of the amendment here (pdf)

This includes MXE, its analogues and many synthetic cannabinoids

You can see the actual proposed legislation here.

I think it is now impossible to know if you are breaking the law unless you have a chemistry qualfication.

 

[dezz]

This is not a social thread.

~Never

 

[Sweetshare]

I noticed that, if consumed frequently, after stop using MXE causes depression (more likely - the depressive phase maniac-depressive illness) for an indefinite period of time.
Anyone willing to confirm that?

 

[Morkin]

Good questions.

Also - were you ever depressed beforehand?

 

[dezz]

I have noticed being depressed while on the drug, even suicidal... feeling like everything is against me, and nobody likes me. I have had this 2 times on MXE. Also it seems to be a gamble sometimes, I've had brilliant glowing experiences on higher doses filled with bliss and good feelings, but last night I felt extremely uncomfortable. Walking made me ill, sitting made me ill, to the point of almost vomiting, only laying down in bed seemed to help, but I'd get the spins pretty bad, also with a headache and a feeling of being twisted and insane. These were all around the 70 mg mark. 40 starter and top off with an hour later. Very strange...

 

[J.Wallace]

I have noticed being depressed while on the drug, even suicidal... feeling like everything is against me, and nobody likes me. I have had this 2 times on MXE. Also it seems to be a gamble sometimes, I've had brilliant glowing experiences on higher doses filled with bliss and good feelings, but last night I felt extremely uncomfortable. Walking made me ill, sitting made me ill, to the point of almost vomiting, only laying down in bed seemed to help, but I'd get the spins pretty bad, also with a headache and a feeling of being twisted and insane. These were all around the 70 mg mark. 40 starter and top off with an hour later. Very strange...

Dosages are irrelevant to me.

However, I notice slight similarities.

Depends on your bodies activities, your mindset, weather, etc.

One thing I notice that happens really quite often...is I've been crying when I take my initial dose. For example, for the past 2 or 3 months I've cut back and have only been doing a gram or two a month at most to myself, as oppose to the 5 or 6 each month I'd do to myself over the summer. Whenever I receive a batch, I indulge for a few days here, a few days there and then it's gone for another 3 or so weeks before I get it again. Whenever I receive a new shipment and I take that first dose, no matter the MG's, I always become very emotional.

In a sense, it's almost become a ritual for me to take 100mg for my first dose in however amount of weeks, followed by me sitting in my computer chair thinking about life...and just, crying for a good 2 or 3 minutes. It's almost like a purge of emotions within me. It's...odd, but...not a negative.

I notice I become extremely emotional while on this substance, meaning I "feel" a lot deeper.

 

[THCified]

^ I could think of these negative experiences as a result of taking MXE too often, too regular.

 

[dezz]

Hmm, but the first time I tried MXE was also horrible (depressive thoughts etc). It actually became better the more I did it. But yeah I need a good break from this substance anyhow.

 

[edzeppelin]

I noticed that, if consumed frequently, after stop using MXE causes depression (more likely - the depressive phase maniac-depressive illness) for an indefinite period of time.
Anyone willing to confirm that?

I've never noticed anything but anti-depressive after-effects. But I only take it once a week in lowish doses now. When I first got it two years ago, five weeks of low daily doses created a tolerance that took a year to go down. So watch your quantity and frequency of dosing, if only for tolerance reasons. Individual response is highly variable, perhaps different batches are of different quality/composition. Also, I wonder if you are sensitive to the seretonin effects of MXE?

All reasons to cut your usage, IMO. Hope you feel better.

edit - I only have uni-polar depression BTW.

 

[J.Wallace]

It should be noted, from my previous post above, that when I cry...it's not a result of me feeling depressed or sad...but from a sense of realism and strong emotion coming into my senses. Like I said before, it feels like a purging of the soul and senses, as though I'm letting some demons free. And it actually feels good!

Usually I'll think about friends, or my father who is getting older. I worry bout him, for example, and what is gonna happen when he isn't around anymore (He is 62 now, he's getting up there in age) and I have no real family to help support me at this point in time, so I usually cry and cry for a good 2 minutes, but it's not a "Fuck, I hate my life" kind of purge, it's more of a "This is reality, as horrible and sadistic it is, it's also beautiful and bittersweet".

It's neither good, nor bad. It's just...right in the middle. I'd imagine in the long run it's a little more positive rather than negative, as it helps me and almost forces me to face these thoughts of the real reality

--------------------------------


Aside from that, I want to add some things about my experience with 100mg last night (Received a new shipment).

So, I took out my scale and weighed out 100mg. I'm using my scale now to dose by the way! I use to always eyeball big lines and bumps, now I'm only dosing measured amounts at a time...helps me conserve and not waste as much material, as well as controlling the experience through proper dosing.

Anyhow! I dosed 100mg last night in one giant line. In retrospect, though it wasn't overwhelming, I still should have spaced it by 50mg then 50mg 10 or 15 minutes later. But, I dosed a 100mg line right up my left nostril and went to the edges of an M-hole. I had been awake for 32 hours, worked two shifts at work and was exhausted. To be honest, I KNEW I shouldn't have dosed considering my state of sleep deprivation and what it's done to me in the past, but I did regardless.

I noticed...I became very delusional, more so than I usually do. See, my room was a mess...and my job, which I just worked double shifts in 32 hours on no sleep, consists of me counting inventory...very, very, very methodical and tedious. My room was a mess, and all I could see was tags on every one of my items (None were really there, just my imagination). I kept hearing voices and seeing my co-workers at the corner of my eye. For example, I heard my coworkers having conversations in my head about me while I sat in my chair in an M-hole, almost as if I was somewhere else, where they were, and was observing them from an out of body experience of some sort while still being conscious of my bodies surroundings.

I never had anY real hallucinations, but in my peripheral vision I could visualize different people and things. I actually heard things and voices as though my apartment was a crack house, people coming and going, different rooms being different zones, such as the dope fiends and the junkies. I could force my thoughts into certain directions to accommodate my trip and visualize and hear different auditory things.

Overall, it wasn't anything unusual or beyond what I've experienced in the past. I like that I started measuring my doses, and despite my use continuing, I've gotten to a point where redosing is not necessary for me to enjoy the experience. I dose, maybe dose ago a few minutes later (Staggered doses are the only way to properly M-hole, as I've stated in this thread along with many other experienced users such as myself) and that's it, I'm done.

One thing I've noticed about this substance, the ideal dose time is in the morning or within 4 or 5 hours of waking up, that is the sweet spot. Never ever dose when you've been awake longer than 12 to 14 hours. I've noted that it takes me AT LEAST 6 to 7 hours after my final dose to be able to fall asleep properly. This is very frustrating at times, especially when I come home from work and all I want to do is dose and go into a hole, yet I know it's the last thing I should do considering my exhaustion.

 

[dezz]

I get what you are saying about purging of the senses, I felt sad while on it, but when the experience ended it lifted inmediatley, and I felt better then normal. In my case it was definitley depression (thinking in negative ways about anything) but it did felt like a "release" of some sort. What strikes me as odd is that I seem to be one of the very few who can sleep on MXE. I would even go as far as to say I actually like sleeping on it. I have dozed off and fell asleep holing a few times, only to wake up 4-5 am to piss and I'll be still heavily tripping.

 

[J.Wallace]

I get what you are saying about purging of the senses, I felt sad while on it, but when the experience ended it lifted inmediatley, and I felt better then normal. In my case it was definitley depression (thinking in negative ways about anything) but it did felt like a "release" of some sort. What strikes me as odd is that I seem to be one of the very few who can sleep on MXE. I would even go as far as to say I actually like sleeping on it. I have dozed off and fell asleep holing a few times, only to wake up 4-5 am to piss and I'll be still heavily tripping.

When I first discovered MXE and I began ordering from my vendor, I had a low tolerance, so 50 to 60mg was enough to have me confused and not wanting anymore. 50mg was the sweet spot for me. As time went on, as I continued to abuse this substance, it turned from a Ketamine like high to a manic stimulated high more along the lines of what I imagine PCP to be like. It went from wobbly, Ketamine/Nitrous/LSD like to Manic, Stimulated schizophrenic delusional type highs. First it became more stimulating than dissociating, now it's more manic and delusional than anything else.

I've come to love the body high this produces, and I think it's the main reason I take such above average doses in one go besides the fact that I have a natural tolerance now. When I first received it, I wouldn't mind laying in bed for hours trying to fall asleep, simply because the CEV's and the wavy wobbly body high kept me entertained. Now most nights when I try falling asleep I feel more stimulated and cracked out, too much to the point where I don't enjoy it.

 

[dezz]

That sounds like a lame experience man. No offence but if I was getting these effects I would just quit. After some experiences I really think this shit has the capacity to make you batshit insane.

 

[J.Wallace]

That sounds like a lame experience man. No offence but if I was getting these effects I would just quit. After some experiences I really think this shit has the capacity to make you batshit insane.

It without a doubt has already made me batshit insane.

I may seem coherent and fine in my words and what not but I am pretty sure I have gone over the deep end as far as being mentally insane is concerned. A lot of people seem to think I've lost my mind. At times I feel perfectly normal, other times I feel like I'm hopelessly lost in insanity and madness. I feel like I'm perma tripping forever on this stuff to be perfectly honest. Not even sure why I keep doing it to be perfectly honestly.

I got 2 grams on Friday, been taking small doses throughout the weekend, but plan on stopping come Monday when I gotta go back to work. I really should lay off this stuff for another month or two. It's gotten too weird for me to really enjoy.

 

[Sweetshare]

I think it has something to do with the depletion of the dopaminergic system. If possible. Approximately as in the case of amphetamine.

 

[dezz]

After a weekend of speed I have also noticed pretty bad delusional effects. I'm with ya sweetshare, I don't think this drug is any good for a dopamine depraved brain

 

[J.Wallace]

I've been here before, I've used 6 grams in a matter of two weeks, before that I used 6 grams in a matter of a month. I've stopped and had no problems not using or caving and ordering more, it's just a matter of "Why am I still doing this?". At times I get so cracked out, that I dose and it doesn't even do anything to me, it's as though all my dopamine or something is depleted and I'm just inhaling material as a psychological thing, ya know? It's really quite pointless.

What's really quite bad is, I have a really bad habit of continuing to use even beyond when I know I need to stop and just get some sleep. I'm an insomniac to begin with. While most people run on a 24 hour body clock, I feel as though my mind and body run on a 32 hour clock instead, and my days and nights are all messed up. I often feel exhausted while being stimulated mentally to the point where I won't even attempt sleep despite my overwhelming tiredness. Throw in a habit of abusing substances and it makes it so my body is often a mess. I'd really like to stop. I mean, I've gotten a hell of a lot better, I measure my doses now and keep track of how much I've taken, but still...the fact that I use even when I know there is no point to keep going just shows I have something wrong with me. Also the fact that the highs are bordering are full blown manic psychotic now due to more often than not my lack of sleep and over exhausting sleep deprivation just makes this something that is completely unhealthy as a whole.

I'm getting better though. I try to use pot when I get to those points of exhaustion, I try to basically knock myself out with some weed so I can get some much needed rest. Unfortunately more times than not I don't have any cannabis when I get to those points of exhaustion.

 

[twelvesevndi]

MXE has no affinity for dopamine, only serotonin and NMDA.

i assume you're saying that because of the recent binding assay study carried out in UK but that study also tested Ketamine and PCP and those substances did not pass the screening criterion at D1 - D4 or DAT. but of course Ket and PCP do have some affinity at D2 (quickly found source) . and i'm sure I've heard people talk about both being DRIs?