
Chemistry
MDPV can be prepared by modifying the alkylation-oxidation-bromination-amination route to cathinone analogs. This involves a Grignard alkylation of piperonal, oxidation of the resulting secondary alcohol back into a ketone, alpha halogenation of the aromatic ketone with bromine, and subsequent amination with pyrrolidine.[16]
The α,α-dibrominated or α-mono-brominated intermediate from the 3rd step bromination, and left behind by an expedited or incomplete final workup is the most likely contaminant/impurity to be seen in the final product using this method.[6] Bromination is likely to in excess, since excess pyrollidine amine will form a black precipitate that is difficult to separate.
Such brominated halo are of particular concern to eukaryote macro-biological organisms, and special consideration must be made when preparing MDPV for purposes of long-term biological testing on lab animals, especially in mammals, and especially where the possibility exists for diversion and subsequent ingestion by humans for recreational purposes. Preparation for biological purposes and testing must ensure a complete and through workup, including several washes with saturated NaHCO3[6] solution after washing with water to remove the brominated intermediates before final salting of the freebase for recrystallization. Aside from the bromine ion being highly electronegative and reactive, the alkyl-bromine compounds often being alkylating agents, and brominated aromatic derivatives being implicated as hormone disruptors, there also exists the mechanism for bromine substituting for the methyl group in the nitrogenous base 5-methyluracil of DNA, creating the base-analog 5-bromouracil, which can be incorporated into DNA and induce a point mutation via base substitu

Thanks guys! So either we're gonna be x-men or cancer patients. I'm hoping like fuck it's not the latter but it doesn't really sound good to me...
*Edit*
Considering the fact that most mdpv is made in shitty Chinese labs I highly highly doubt they take much precaution when synthing this stuff. They don't care at all about the impurities only the money! Best of all, we're SMOKING this stuff! Impurities and all. Oh dear god I'm thinking I shortened my lifespan with this stuff, I really do.
Shambles you're a cool dude ya know that? At least so far as one can be certain about something such as that over the internet. But I quite enjoy reading your posts, often makes me a crack a smile.
Everything you say is true, this is ultimately the risk we take and I always knew the possible consequences. Turned a few friends onto mdpv and remember explaining to them that we're rolling the dice, we don't know about the long term consequences. I'm a smoker too, I'm 24 years old and I been at it since I was 17 knowing full well it's a mutagen so yeah even with all the knowledge at hand we often don't make the best decisions.
The sad truth is I don't really think we'll ever know much about mdpv. It came and it went, before too too long I think it will be a thing of the past. I don't think that there will ever be anyone much interested in funding research on what will eventually be a scheduled compound worldwide. I just can't see the interest.
Mdpv isn't my only concern, I've smoked my way through gram after gram of am-2201, jwh-018, jwh-071, jwh-122, jwh-210, ur-144, and 5f-ur-144 knowing fuck all about them except that people weren't dropping dead left and right from them. And I STILL roll the dice, I have a packed order of mam-2201 and apvp waiting to be shipped out Monday. If it weren't already packed I would have changed my mind on the apvp.
My biggest concern regarding mdpv is undoubtedly for my kidneys. I've been thinking about getting them tested because I've had awful renal problems during my mdpv binges. I'm not certain but I think they're not quite as good as they once were. And renal problems will undoubtedly only get worse.
You guys and your Wikipedia 8)
What's scaring the living shit out of me right now is bubbles in my urine. Even when I pee in a cup there are bubbles on top and it could be an indicator of proteinuria, protein in the urine. Protein is not supposed to pass through the filtration system in your kidneys and if it is I could have kidney failure.
On mdpv I always had a full feeling in my kidneys which would progress to outright renal pain. My urine was often very dark orange and once or twice was brown. A few times I was in agony and felt like I had to piss so bad but nothing would come out. When I finally was able to that was when it was brown.