Some Opiate Questions

[someone12345]

Hi,

I have recently began taking oxycodone and have a couple of questions

1. I have yet to experience any kind of euphoria. I have tried doses between 10mg and 30mg and the only effects I am noticing is drowsiness, impaired motor coordination, etc... none of the amazing orgasmic rush I hear other people experiencing. Could anyone shed some light as to why this is happening? Some quick research shows me that a small percentage of the population suffers from a CYP2D6 enzyme deficiency which prevents them from effectively metabolizing opiates. Is there any way to bypass this?

Additionally, I am very prone to nausea so I have been taking diphenhydramine with each dose (about 50mg-100mg); I have also read that diphenhydramine actually inhibits the same CYP2D6 enzyme which is not a good thing for a person like me who is chasing the euphoria. Does anyone know if there is truth to this or is able to expand upon it a little more?

2. About an hour or so after dosing (I usually take 10mg every 45 minutes until I have taken 30mg~) I notice my cheeks turn red which I am convinced is a symptom of my high blood pressure being exacerbated by Oxycodone. I didn't know opiates had the potential to raise blood pressure but I am fairly sure this is what is happening. It's not exactly having a negative effect on me in anyway but it is always nice to prevent high blood pressure when you can.

3. I have also noticed that about an hour or so after dosing I get extremely agitated and irritable. I become very sensitive to sound and am very "jumpy". It isn't pleasant. Do opiates have the potential to do this or is it possible that this is a side effect of the diphenhydramine? I take the DPH regularly at nights but do not experience the irritability in this capacity so it must be the Oxy.

Sorry about the wall of text. Any comments or thoughts are much appreciated

P.S. I know I shouldn't be dabbling in opiates

 

[Jabberwocky]

oxycodone is a bitch, your tolerance sky rockets so quickly and it loses all its magic so quickly

oxy definately has a super high the first time you take which you wont forget. but its near impossible to get that back unless you take an enormous break from opiates.

i wouldnt take that dph, 10-30mg of oxy wont make you that sick, and it taints the high too much. if you start feeling sick on oxy then yeah take one, otherwise no. dph ruins an opiate high for me (personally) whatever opiate it is. i hate taking all that extra crap with opiates, it ruins the high completely. unless its benzos (WHICH I DONT RECOMMEND - extremely dangerous).

my cheeks also turn red from opiates but my body temperature also increases, at higher doses i start sweating like a bitch too

to 3. - yes i have noticed that too, its not after an hour, maybe 3-4 hours after dosing for me i get very irritated (at even the slightest things) i have no idea how to explain it but it happens. i think its because opiates are so fucking good and you've lost that high feeling you get irritated.

no idea if any of this is helpful

 

[someone12345]

oxycodone is a bitch, your tolerance sky rockets so quickly and it loses all its magic so quickly

oxy definately has a super high the first time you take which you wont forget. but its near impossible to get that back unless you take an enormous break from opiates.

i wouldnt take that dph, 10-30mg of oxy wont make you that sick, and it taints the high too much. if you start feeling sick on oxy then yeah take one, otherwise no. dph ruins an opiate high for me (personally) whatever opiate it is. i hate taking all that extra crap with opiates, it ruins the high completely. unless its benzos (WHICH I DONT RECOMMEND - extremely dangerous).

my cheeks also turn red from opiates but my body temperature also increases, at higher doses i start sweating like a bitch too

to 3. - yes i have noticed that too, its not after an hour, maybe 3-4 hours after dosing for me i get very irritated (at even the slightest things) i have no idea how to explain it but it happens. i think its because opiates are so fucking good and you've lost that high feeling you get irritated.

no idea if any of this is helpful

it does help man, thanks. i am just trying to make sure these side effects are not exclusive to me. I think the 3-4 hour mark is actually more accurate as well. i'll try taking it in the future without the diphenhydramine and see how it goes.

 

[Swimmingdancer]

1. I have yet to experience any kind of euphoria. I have tried doses between 10mg and 30mg and the only effects I am noticing is drowsiness, impaired motor coordination, etc... none of the amazing orgasmic rush I hear other people experiencing. Could anyone shed some light as to why this is happening?

The "amazing euphoria" is kind of over-exaggerated ("orgasmic rush", maybe if you're injecting certain opioids (not oxy) and that rush does not last very long - but do NOT inject!). The opioid high is more subtle, like feeling pleasant, comforted, warm, free of physical and emotional pain, like the feeling of being loved or hugged. Opioids are quite a natural feeling, and can be an acquired taste. My advice: stay far away from them before you end up enjoying them! It's totally NOT worth the risks of addiction.

Having said that, different people react to different opioids in different ways. Some people don't get much out of certain ones. Different opioids are derived from different opiates or are completely synthetic, and they have differences in the ways they are metabolized. It is quite common for a person to not get much out of one opioid but get strong effects from another. NOT that I suggest you start trying different opioids.

Some quick research shows me that a small percentage of the population suffers from a CYP2D6 enzyme deficiency which prevents them from effectively metabolizing opiates. Is there any way to bypass this?
Additionally, I am very prone to nausea so I have been taking diphenhydramine with each dose (about 50mg-100mg); I have also read that diphenhydramine actually inhibits the same CYP2D6 enzyme which is not a good thing for a person like me who is chasing the euphoria. Does anyone know if there is truth to this or is able to expand upon it a little more?

It's more complex than that and it depends on the drug - different opioids are different. I'll explain for oxycodone since that's the one you were talking about:

"Metabolism" just means the body changes the drug into something else, there can be both metabolism to active metabolites and inactive metabolites. You want your body to metabolize it more into active metabolites and less into inactive metabolites. Oxycodone itself is active and believed to be responsible for a portion of the drugs effects, but many people agree that the active metabolites are needed for full effects and perhaps especially for euphoria. Oxycodone is partly metabolized into active metabolites such as oxymorphone by CYP2D6. However, some studies have found that inhibiting CYP2D6 didn't make much difference (however, it should be noted, studies are aimed at evaluating pain-killing effects and not euphoria). CYP3A4, is the primary metabolic pathway for deactivating oxycodone, so the theory is that having an abundance of CYP34A activity would be more likely to decrease the effects of oxycodone. Anyway, the first thing I would try would be taking the oxycodone without the diphenhydramine. In addition to its effects on CYP2D6, it may be masking some of the opioid effects - by the way 100mg of diph is too much and this includes when taking it for sleep (less is more - let me know if you want to know why). If you get nausea try using Gravol Natural Source Ginger Tablets instead - I find they work surprisingly well. If removing the diph didn't help, the second thing to try would be take a CYP3A4 inhibitor. Some CYP3A4 inhibitors include grapefruit juice, valerian, bergamot, cimetidine, and many other things (including a number of foods). The better thing to do would of course be stop using oxycodone.

2. About an hour or so after dosing (I usually take 10mg every 45 minutes until I have taken 30mg~) I notice my cheeks turn red which I am convinced is a symptom of my high blood pressure being exacerbated by Oxycodone. I didn't know opiates had the potential to raise blood pressure but I am fairly sure this is what is happening. It's not exactly having a negative effect on me in anyway but it is always nice to prevent high blood pressure when you can.

Opioids do not usually raise blood pressure, they lower it. It's possible that if you are experiencing irritation/agitation or anxiety this would raise your blood pressure, but the flush on your cheeks may be caused by something else. I would suspect vasodilation, the widening of the blood vessels, which is a common effect of opioids. It's like how people's faces often turn red when they drink alcohol.

3. I have also noticed that about an hour or so after dosing I get extremely agitated and irritable. I become very sensitive to sound and am very "jumpy". It isn't pleasant. Do opiates have the potential to do this or is it possible that this is a side effect of the diphenhydramine? I take the DPH regularly at nights but do not experience the irritability in this capacity so it must be the Oxy.

Yes, opioids can definitely make you irritable. Some more so that others. This seems especially common when you haven't used that particular opioid very much. I don't think it's just when it starts to wear off though (so I don't agree with synthetix on that).

 

[someone12345]

Thanks for that swimmingdancer. Very informative. If you don't mind, could you expand upon this part "less is more - let me know if you want to know why" ?

I am very interested

Best Regards

 

[Swimmingdancer]

Thanks for that swimmingdancer. Very informative. If you don't mind, could you expand upon this part "less is more - let me know if you want to know why" ?

Sure no problem

Basically an antihistamine is not JUST an antihistamine (regardless of marketing), it will have varying binding affinities for other receptors that have different effects, so you want a dose that primarily gives you the histamine antagonism yet has little activation of other receptors that cause more stimulating effects. Diphenhydramine has the most affinity for histamine receptors, meaning it likes them best. But when you take more of it, more goes to other receptors, whereas if you just take a low dose of diph, little is going to those other receptors so you don't get much effects from them. Diphenhydramine also has M1 acetylcholine blockade (dry mouth, constipation, confusion), and significant norepinephrine and serotonin reuptake blockade (like an antidepressant). People's most common mistake with diph is to take higher doses if they feel it's not working, when really for most purposes (especially sleep, but you really don't need much for nausea either) less would be better, I'd say around 20-50mg depending on the person.

Problem is, tolerance to sedation from antihistamines can build very rapidly. One study on diphenhydramine for example found sedation to be equal to placebo after just 4 days of daily use. And when tolerance builds, taking higher doses is not going to help because then you get more of the other effects.

 

[Flo-Rida]

I used to be an Oxy user for over 3 years, so here's some advice for ya.

Hi,

I have recently began taking oxycodone and have a couple of questions

1. I have yet to experience any kind of euphoria. I have tried doses between 10mg and 30mg and the only effects I am noticing is drowsiness, impaired motor coordination, etc... none of the amazing orgasmic rush I hear other people experiencing. Could anyone shed some light as to why this is happening? Some quick research shows me that a small percentage of the population suffers from a CYP2D6 enzyme deficiency which prevents them from effectively metabolizing opiates. Is there any way to bypass this?

First thing you need to understand is that everyone is different. How a drug effects one person might not mean you'll see the same results. With that said, when I first started out with Oxy I immediately starting taking 30mg doses at a time of pure Oxycodone. For me personally, the first few times I dosed it made me sick. It wasn't very enjoyable being that I was an "Oxy virgin" at that time. I experienced the same thing you did, drowsiness, motor skills effected (i.e., stumbled when I walked), etc. But there WAS euphoria, even if very little at first. After I used it for a while (by a while I mean a week or so) and got used to it, I eventually upped the dose and started to experience MOSTLY euphoria. IMO, I just had to give my body time to adjust to it. I eventually moved on to snorting it and the rush was instantaneous. Once I finally became physically addicted to it and would suffer withdrawals, the euphoria started to become instantaneous whenever I had some. The reason is because my brain stopped naturally producing dopamine and the only way I was getting it was with the drugs. Just keep that in mind.



Additionally, I am very prone to nausea so I have been taking diphenhydramine with each dose (about 50mg-100mg); I have also read that diphenhydramine actually inhibits the same CYP2D6 enzyme which is not a good thing for a person like me who is chasing the euphoria. Does anyone know if there is truth to this or is able to expand upon it a little more?

I can't comment on the CYP2D6 thing. I have only ever used diphenhydramine as a sleep aide. Are you sure you're not talking about dramamine? I would not recommend taking diphenhydramine with with Oxy. Both of them alone will make you tired, but combined together and you have a cocktail that equals extreme drowsiness and impaired motor skills.



2. About an hour or so after dosing (I usually take 10mg every 45 minutes until I have taken 30mg~) I notice my cheeks turn red which I am convinced is a symptom of my high blood pressure being exacerbated by Oxycodone. I didn't know opiates had the potential to raise blood pressure but I am fairly sure this is what is happening. It's not exactly having a negative effect on me in anyway but it is always nice to prevent high blood pressure when you can.

If anything, Oxy would lower your blood pressure. It will suppress the central nervous system, i.e. lower heart rate, breathing, etc. 90% of people take Oxy don't even notice this happening, I certainly never did. Oxy CAN cause flushing (redness of the skin, sometimes your skin will feel hot). It can also make you itchy, especially when you're coming off of it. When I did Oxy, it made me itchy, but I never noticed redness of my skin. If you're experience this and it's not bothering you or effecting you otherwise, I'd chalk it up to a MINOR side effect. If it was making your cheeks run and doing other stuff like closing your throat (making it difficult to swallow or breathe) then I'd say you're allergic to it and to stop taking it. As for the way you're dosing, that might be another reason you're not getting euphoria. If I were take 10mg of Oxy right now I KNOW I wouldn't feel a damn thing. When it comes to your dose you not only need to account for tolerance level, but body weight as well. If you're a big guy, just should for the 30mg all at once and see where that gets you.



3. I have also noticed that about an hour or so after dosing I get extremely agitated and irritable. I become very sensitive to sound and am very "jumpy". It isn't pleasant. Do opiates have the potential to do this or is it possible that this is a side effect of the diphenhydramine? I take the DPH regularly at nights but do not experience the irritability in this capacity so it must be the Oxy.

Yes, Oxy will make you irritable when you're coming off of it. When you're ON it, you should be happy, euphoric, and generally in a good mood. But even after 3 years for me, I would get a little pissy coming off of it, even a few times to the point where I would freak out and get in fights with people. Chances are you're never adapt to this, you just need to learn how to cope with it.

As for the DPH, I know in really HIGH doses it can make you extremely irritable and restless. Combined together, again, it might just make things worse. The dose as which you're taking the DPH is usually prescribed for people who need it as a sleep aide. 100mg of DPH will make you tired and is designed to get your brain to shut off and goto sleep. But when you fight it and stay away, it can most certainly make you upset and ancy.

Sorry about the wall of text. Any comments or thoughts are much appreciated

P.S. I know I shouldn't be dabbling in opiates

 

[BlueHues]

If opiates aren't doin it for you, don't take them!...I wish they didn't "do it" for me! Shit.....Are you hanging out with a bunch of Oxycodone addicts? If you can avoid getting into this shit, it's a big plus, believe me(us)! It gets bad! What's the point of playing around with a dangerous and addictive drug you don't really even like!! at it's best, oxycodone is not a glamorous and exciting drug, it's kind of just boring, destructive and expensive!

 

[Mr.Scagnattie]

If opiates aren't doin it for you, don't take them!...I wish they didn't "do it" for me! Shit.....Are you hanging out with a bunch of Oxycodone addicts? If you can avoid getting into this shit, it's a big plus, believe me(us)! It gets bad! What's the point of playing around with a dangerous and addictive drug you don't really even like!! at it's best, oxycodone is not a glamorous and exciting drug, it's kind of just boring, destructive and expensive!

Well said, Hues. Seconded.

 

[someone12345]

Alright guys thanks again for the awesome information. Very helpful. I'll heed your warnings and stop experimenting once I run out (isn't that what everyone says? haha)

Anyways - just one question and I'll be out of your hair

1. I noticed when laying on my back and trying to fall asleep, every 5 or 10 seconds I would experience like a quick short exhalation. It's almost like a quick snore; however, there is no build up to it and it happens very randomly. I think I might be nodding out and this short burst is waking me back up. It's actually kind of scary. Has anyone else experienced something similar to this?

Best Regards

 

[EEhouseEE]

Buddy what you said at #3....about taking 10mg then an hour later taking another dose, donttt do that thats the reason your not really getting high.
Take a whole 20-25 mg at once to feel the acctual euphoria and high.

Usually with opiates you have to become accustomed to that feeeling before you can start enjoying it.

 

[Swimmingdancer]

1. I noticed when laying on my back and trying to fall asleep, every 5 or 10 seconds I would experience like a quick short exhalation. It's almost like a quick snore; however, there is no build up to it and it happens very randomly. I think I might be nodding out and this short burst is waking me back up. It's actually kind of scary. Has anyone else experienced something similar to this?

Yep, that's pretty common when nodding hard. Maybe try taking a bit less.

 

[Jabberwocky]

Thats a pretty dangerous symptom you're describing. You should also be aware if you're snoring loudly at night, I wasn't aware of this before, but apparently it's a symptom of overly depressed respiratory systems. Definitely lower your dose if this is happening to you.

 

[laCster]

1. I have yet to experience any kind of euphoria. I have tried doses between 10mg and 30mg and the only effects I am noticing is drowsiness, impaired motor coordination, etc... none of the amazing orgasmic rush I hear other people experiencing. Could anyone shed some light as to why this is happening? Some quick research shows me that a small percentage of the population suffers from a CYP2D6 enzyme deficiency which prevents them from effectively metabolizing opiates. Is there any way to bypass this?

Additionally, I am very prone to nausea so I have been taking diphenhydramine with each dose (about 50mg-100mg); I have also read that diphenhydramine actually inhibits the same CYP2D6 enzyme which is not a good thing for a person like me who is chasing the euphoria. Does anyone know if there is truth to this or is able to expand upon a little more?

2D6 or 3A4 deficiency would actually make the oxycodone feel really really strog. to potentiate oxy, you want to inhibit 3A4 mainly and 2D6 because those enzymes metabolize oxycodone into mostly inactive metabolites. however, you could have very active enzymes which process and metabolize active compounds quicker than other people. i doubt it though...

diphenhydramine is a good tool for a drug-user. DPH increases sedation, stops the itches, decreases nausea, and inhibit and enzyme more drugs are metabolized through. taking diphen with opiates is totally winning, but i dont think DPH is causing you not to feel the oxy. diphenhydramine should do the opposite actually; by synergizing and potentiating these with oxycodone, the oxy should feel stronger. benedryl wont make the opiate more euphoric, but you will experience reduced nausea, potentiated by 2D6 inhibition, and most importantly you will feel more sedated and fall into a nodd easier. idk about you, but if im fucked up to the point im nodding, im feeling good

how many times have you done oxy?


3. I have also noticed that about an hour or so after dosing I get extremely agitated and irritable. I become very sensitive to sound and am very "jumpy". It isn't pleasant. Do opiates have the potential to do this or is it possible that this is a side effect of the diphenhydramine? I take the DPH regularly at nights but do not experience the irritability in this capacity so it must be the Oxy.

aggitation and irritability is common with opiates, especially oxycodone. for some reason, oxy makes people go on opiod-rage.. many people, including myself, get really annoyed on oxy because they want to enjoy my high, the anger is not caused by diphenhydramine, i can promise you that.

 

[Blue30]

If all ur getting from opiates is agitation and itchiness I would say stop while u can. I take large doses of opiates for pain control and cannot begin to explain to you how much it sucks to be so completely dependent on a substance. Maybe opiates just aren't the drug for you there are many other,safer substance to use that you might enjoy more. I also agree with synthetix about not taking the dph I don't like to mix anything with my opiates it just masks the feeling I'm wanting.

 

[Tosh.Suku]

Oxy gives back the feelings it took away from you so the more dependent you become the more euphoric the high is described

 

[pally pete]

If opiates aren't doin it for you, don't take them!...I wish they didn't "do it" for me! Shit.....Are you hanging out with a bunch of Oxycodone addicts? If you can avoid getting into this shit, it's a big plus, believe me(us)! It gets bad! What's the point of playing around with a dangerous and addictive drug you don't really even like!! at it's best, oxycodone is not a glamorous and exciting drug, it's kind of just boring, destructive and expensive!

Well said.

 

[Pagey]

1. IME the 'euphoria' people talk about in relation to opiates is a bit exaggerated. For me it's more of a 'strong contentment'. There also isn't any rush on oxy, that's normal. Although PLEASE do NOT try anything that has one...you'd regret it.
3. It isn't at all unheard of for people to become irritable on opiates.

I'll second what everyone else has said - if you're not enjoying the oxy, stop taking it. Honestly you should be glad it doesn't work for you

 

[shimazu]

idk about you guys but if im really bent on opiates, like well into nodding level, and I sit down and tilt my head back like im looking straight up, I get this intense rush of feelings in my whole body. Its not even really a good feeling though, just like an overwhelming feeling of being really high. But if I put my head back down level it goes away instantly

 

[Pagey]

^yeah I get that too, it kinda makes me feel sick though