N&PD Moderators: Skorpio
Nootropics of the future
Jabberwocky
Frumious Bandersnatch
ok good luck, be careful (iirc you were dealing w/ some nasty anhedoia (sp?) and don't want you to go exacerbating ;]
I know what im doing and experimenting is what i do alot of the time
(wich allowed me find working effective stuff that helps)
knockout_mice
Bluelighter
link.springer.com/content/pdf/10.1007%2Fs10517-008-0297-x
Download the pdf and have a look at the graphs. It's really promising.
Jabberwocky
Frumious Bandersnatch
can you put them into the thread?
/you're too new for me to comfortably "allow this page access" and see what's there.
knockout_mice
Bluelighter
Well, of course. But my link points to Springer.com, not to my unknown home server IP address
Jabberwocky
Frumious Bandersnatch
lol that shit may as well be greek, have zero clue what that means.
/will show myself out.
Microbiologist
Greenlighter
fig 1 demonstrates the effect of noopept administration: increasing expression of brain derived neurotrophic factor and nerve growth factor in rat hippocampus. Although what groups acute/chronc administration, etc is not supplied in the figure legend, also a housekeeping gene mRNA expression control would be good, but perhaps this is explained in the article proper.
table 2 shows that relative to saline control, acute noopept administration decreases both BDNF and NGF expression in the cerebral cortex but increases expression in the hippocampus. Additionally, noopept administration continued for 28 days increases BDNF expression but has no significant effect on NGF in the cortex, and again in the hippocampus both BDNF and NGF are increased over 2-fold.
increased mRNA expression is a good indication of increased protein (BDNF, NGF) content; although it is not confirmatory, as translational bottlenecks, increased protein turnover or other factors may be at play.
Tony Williams
Bluelighter
Noopept i heard wasnt that good but yet to try myself, V potent mg wise!!!. I use 2.5g OXIRACETAM twice a day or onec and 2.5g Aniracetam (wITH FAT) CHolie Citric I got too
I have pure CQ10. thinking of other stuff I might stockup on. Maybe some STIMS are NOOP considered CONCERTA. ETH, MPH, ADD/AMPH and then down to Cocaine (COCA FORM), MODNAFIL (DYING to give moddy another go. Caff, EPH (EPDRINE), KHAT
I would like a stim onto of my stack of racetams - my briain is wrongly wired. I have 100's on my TODO yet Inwaste time. Cmoe bed time I wont sleep just stay up and "get stuff done" next day my energy lvl must drop as I spend all day on forums, doing;/injecting drugs, chat when I reakky need to clean up here the quicker i can go mad and dedcoratte and get FISH
Jabberwocky
Frumious Bandersnatch
probably ill-advised to post about your plans to "stock up on" shit like amphetamines and coke. FWIW.
and stop kidding yourself that noots are even remotely useful to your mind when you're slamming drugs, you know damn well you gotta fix the big shit 1st 
Been eyeballing Noopept doeses for about a week now and not noticing much. It has that 'racetam feel' but nothing special.
I've noticed some interesting interactions between Modafinil and Lyrica that, if I didn't have a limited Lyrica supply, I'd investigate. Lyrica's inhibitory effects seem to clear up a little of the pressure that Modafinil lays on.
Last edited by a moderator:
SONN
Bluelighter
does this mean that the nerves in your frontal cortex are having their development stunted? meaning it's making me dumber in one way while smarter in another???
knockout_mice
Bluelighter
It means, that acute noopept administration makes you "dumber in one way", while chronic use does the opposite. In other words: tolerance builds up for the "dumbing", but not for the nootropic effect, even the latter will be more pronounced with multiple separated doses.
SONN
Bluelighter
so if I take 5-10mg doses daily, or maybe twice a day (whenever they're needed) and don't take more than the minimum amount i'd need it'd be better in the long run rather than taking 20+mg much less frequently to study?
what do you think would count as acute?
knockout_mice
Bluelighter
You're right. According to this study "acute" means one isolated dose. 10-20 mg daily should be fine.
Tony Williams
Bluelighter
probably ill-advised to post about your plans to "stock up on" shit like amphetamines and coke. FWIW.
and stop kidding yourself that noots are even remotely useful to your mind when you're slamming drugs, you know damn well you gotta fix the big shit 1st
I was not advising people do that. I was saying ontop of racetams a mild stim like caffiene coca moda helps alot. People use with amphet, con/rit too but that's not safe/healty. I've a problem with MPH/ETH abuse and staying up - I use racetams too but I cant tell it's working, when I stash away them and stay off and be clean I notice them better and usually just add coffee - I would like a low concerta dose but I prove I will just end up doing more.
Thats interesting when I try mod next I wanna give it a go with lyrica I aint any now but usually get huge amounts I find it mixes with stims like crazy.
Last edited by a moderator:
A very different kind of drug design:
A neuroprotective/neurotrophic/nootropic drug is created starting from two substances that have complementary effects in different models, but more or less similar chemical stucture. Hybrids of these two substances are synthesized and the most effective is further optimized.
http://www.ncbi.nlm.nih.gov/pubmed/22194796
Massively improved cognition with coluracetam today, my output and thinking improved drastically making myself able to make conclusions about stuff i couldnt before (pharmacologically wise).
Definatly interesting stuff.
I have alot more issues then anhedonia and im not carefull, as an example i daily take therapeutic doses of mdai instead of ssri's as a antidepressnt (nichols developped ssra's as rapid acting antidepressant) my condition has massively improved, far beyond what i could do if i was carefull, i know its better to be carefull but im a rheckless person that takes risks, thats just me and no-one can change that haha.
I was predromal shizophrenic, i completely reversed this including shizo typical things i had as a kid, shizo triggers dont even slowed my slow improvement by what i was trying even, now im so far from being shizo i would say i dont have the disorder anymore at all.
As far as im aware no-one ever booked this much improvement in that condition, ive been in wards for psychosis and the people that followed there docs advice (eg being carefull) where complete retards, my cognition was declining to i said no thx to become such a retard and by not being carefull i prevented myself from becoming one, i could have died as well but its worth the risk imo, thats because im a very optimistic person and allways assume a get a good outcome haha.
As an aside i think adding a very strong D2 blocker to stimulants helps my cognition alot too, it allow the da to bind to receptors like D1 and D4 more wich are the motors behind the PFC, D1 is the motor of cognition activating the pfc and the glutaminergic system too. D2 antagonism releases acetylcholine too.
Last edited:
Isochromium
Bluelighter
Nootropics & Nootropic Hyperpotentiators of the Very Near Future:
1. Intranasal (snorting): RAD140 powder
2. Intranasal Metribolone powder
