Bupropion and Amphetamine?

[Lightning-Nl]

[retracted for personal reasons]

 

[dankhead88]

I suppose it tends to reduce the effects of amphetamines due to it's inhibition of the dopamine reuptake transporter, while amphetamines reverses the transporter through phosphorylation. I guess it's like a cork plugging the pump.

That's only what I've read though, I'm no neuro/psychopharmacologist or studying neuro/psychopharmacology, so don't quote me on this. I only read to ensure safety and to prevent the harms that's associated with my drug use(most of the times). However, when I did combine cocaine with methamphetamine.

I did felt as if the stimulation from meth was reduced slightly due to cocaine's inhibition to the dopamine reuptake transporters. Also, according to some articles I've read. Dopamine reuptake inhibitors could possibly prevent the neurotoxicity caused by a dopamine releasing agent such as amphetamines. Almost the same way how SSRI's can prevent neurotoxicity from MDMA due to it's heavy release of serotonin.

I do not condone this combination though for everybody is different and could have potentially devastating and/or adverse reactions. Also, below you are some cited sources.

Cited Sources
Annette E. Fleckenstein, James W. Gibb, Glen R. Hanson. "Differential effects of stimulants on monoaminergic transporters: Pharmacological consequences and implications for neurotoxicity". European Journal of Pharmacology 406 (2000):7

This journal shows great details about the pharmacokinetics and pharmacodynamics of different stimulants and the effects that it causes in the central nervous system

Dr. Magí Farré, Doctor Aiguader. "Pharmacological Interaction between 3,4-Methylenedioxymethamphetamine (Ecstasy) and Paroxetine: Pharmacological Effects and Pharmacokinetics". The Journal of Pharmacology and experimental therapeutics 323.3(2007):954-962. Web

This article undergoes experiments with mice that's administered MDMA and SSRIs like paroxetine.

 

[drminaq]

how bout a survey?

This is one of those questions we all must determine for ourselves. Regardless, I think we all seem to notice the effect is minor.
Personally, I believed my doctor when he refused to up my Vyvnase dose (d-amp) 60 mg and instead added 300 mgs of Wellbutrin. Telling me it would serve to potentiate the Vyvnase. Anecdotally, I must admit I couldn't tell any significant change one way or the other. I felt that the Wellbutrin (DRI) did smooth out the sometimes rocky road of daily amphetamine dosing (for add is my case) and had an over all anti depressant effect along with an increase in libido which was hard to complain about.

I also noticed that the wellbutrin made a slight increase in my overall well being, again hard to say for sure it was this drug for sure. I have been doing some small experiments myself. two weeks with out the DRI (wellburtrin) and two weeks together. I have just completed my first cycle of combing this two...
Again, if there is any synergy or reduction in the euphoria and over all effects of the stimulant it is nearly impossible to tell.

However, the anti-depressant effect of the wellbutrin made me decide to continue with this combo for the time being.

What I would love to see is a referendum on the issue. The question on the ballot something along the lines of...
Do you feel take wellbutrin in combination with other amphetamines prescribed or recreationally? as the first question. The second question, should be 'what is your subjective experience in terms of Synergy or Reduction in stimulation from amphetamines alone?.
I bet we would see the answer isn't such a black and white issue. I would love to be proved wrong though!

I would start this thread myself if I knew that wouldn't be breaking any BL guidelines in posting such a query.

 

[TCMVegas]

drminaw, I'm surprised that you have amphetamine along with bupropion. bupropion is well known for causing seizures, probably due to its NRI-heavy activity

I took a 20mg XR Adderall recently, while one 100mg bupropion for the last month, and it was weaker than I'd have expected (EXTENSIVE experience with adderall last semester). I suspect this happened because:

1) chronic use of an NDRI downregulates these receptors

2) amphetamine had less free reuptake transporters to use in order to get in to the presynaptic cell and mess with VMAT, and release neurotransmitter to diffuse out. (Is this actually how amp gets to VMAT? through transporters? Anyone know?)

 

[P A]

drminaw, I'm surprised that you have amphetamine along with bupropion. bupropion is well known for causing seizures, probably due to its NRI-heavy activity

That's an overblown statistic. Bupropion is no more likely to cause seizure activity in non-epileptic patients than other antidepressants and psychostimulants with similar mechanisms of action.

(Is this actually how amp gets to VMAT? through transporters? Anyone know?)

I remember reading that AMPH is primarily taken up by monoamine transporters, but I also dimly recall something about passive diffusion across cell membranes as well.

 

[polarbearsarecool]

no there is competitive affinities for each at varying receptors and enzymes,. as well as bup antagonizing the alpha 7 nicotonic receptors that must be activated in order for reversal of the transporter to occur.. plus bup will lower the thresh hold due to its light serotonergic mechanism in addition to the amphetamine.. potentiative action

VMAT is main name for the vesicular monoamine transporter.. amph through cascade action disrupts the monoamine vesicles' membranes' causing them to "burst" and fire more rapidly..

excuse brevity.. tiredness....