junglebook
Bluelighter
In my below par logic the question is flawed in ways i will not go into.
The meth and acid are major offenders in regards to long term brain damage. Particularly w/ meth, long term use may result in psychosis. However, I've know individuals who suffer psychosis and go on to obtain post graduate degrees and now work a professionals. Still, it is not something you want obviously.
Aside from that, over time the neurochemistry does correct itself.... mostly. This can be expedited with conscientious dieting, an exercise regimen, and meditation.
They make me exhibit more ocd like behaviors, but i am not OCD.