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4-substituted tryptamine comparisons: 4-ho-MiPT vs 4-ho-DMT and 4-aco-DMT.

✰hyperobjects✰

✰hyperobjects✰

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Jan 9, 2011
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So I have some 4-ho-MiPT I picked up a while back and have been saving for the winter solstice, but I'm curious about how it compares to psilocybin and O-Acetylpsilocin. I haven't worked with 4-aco-DMT at high doses yet, but I was quite surprised with my initial bioassays how similar it seems to be to psilocybin. People say the 4-substituted trypts all push the same psilocin receptor in the brain and the experiences are hard to differentiate, which is weird for me coming from an extensive background in phenethylamines (particularly the 2c-x series) and all of them seem to be unique in their own right.

This will be my fourth 4-substituted tryptamine (4-aco-DiPT, 4-ho-DMT, and 4-aco-DMT) and I'm excited but really curious to see if anyone can comment on the differences between them.
 
I can only compare 4-ho-mipt and 4-aco-dmt, but:

4-ho-mipt:

- More giggly/euphoric
- Extremely clean, no body load and actually quite an MDMA-like body high
- INTENSE sound distortion
- Relatively uninteresting visuals

4-aco-dmt:

- more introspective, deeper
- Clean but some transient nausea has been present before
- Sound distortion similar to mushrooms but not on the same level as 4-ho-mipt
- More visual, CEVs similar to sub breakthrough DMT, OEVs quite similar to mushrooms

Basically, I prefer 4-ho-mipt because it has given the most incredible music enhancement I've ever experienced, bar none. It is also quite euphoric and feels great. 4-aco-dmt has given me a couple pretty incredible trips too though.
 
Imo 4-Aco-DMT and psilocin are nearly the same, or at least 4-Aco-DMT and psilocybe cubensis that i have tried many times.
Contrary to what is said i find 4-ho-Mipt to give far superior OEVs at normal/high dosages.
4-ho-Mipt is more easy and euphoric, but it also lack the depth of psilocin.
4-Aco-Dmt with psilocin gave me some of the most spiritual, deep and illuminatin experiences in my life but in the wrong set and setting also the worst bad trips ever.
I had insane OEVs too with mushrooms but at really high doses like 80g of fresh cubensis or with psilohuasca with nearly 10g dried + harmala, while with 25 or 30mg of 4-ho-mipt i was already tripping with really great visuals, far more intense than 4 or 5 gr of cubensis.
For me both give medium/high bodyload, depending on the dose, for sure i wouldn't be able to dance or walk normally at high doses, but well i would never take them in public, it would be a nightmare.
As said before 4-ho-Mipt is a fantastic music enhancer, maybe the best one in this, at least among the ones i've tried.
So they are both great, it just depends on what are you searching, for an easy and fun trip i would go with 4-ho-mipt while for a spiritual and introspective one i would choose 4-Aco-DMT.
 
I can compare a couple, but not the above. Sorry!

4-ho-met

4-aco-mipt

4-ho-mipt

The latter two seem identical, other than in strength. The ho-mipt seems slightly stronger weight for weight but the compounds came from differing sources, however I do understand from my limited readings here that these two chemicals bring almost identical effects.

My favourite 4-sub psychedelic tryptamine is 4-ho-met! I find this stuff very light & pleasant, I'll happilly redose & extend or strengthen the trip. This seems like a more colourful version of a shroom trip, still giggly & happy, but less deep & not particularly introspective. I've had some pretty dark, deep trips on truffles or Colombian/Mexcan shrooms & some very light, happy, colourful ones on Semilanceata/cyanescens. Comparing the differing effects of the worlds various mushrooms is similar to comparing the effects of different 4-sub tryptamines.

Overall the 4-ho-met seems more fun & the other two seems a little deeper. I've used it on park walks, in conjunction with 4-fa at parties & at a gig as the sole inebriant, which worked very well. I have yet to tuck into a small sample of 4-aco-dmt but it's on the cards & I'm looking forward to it.
 
IMO:

4-HO-MiPT

- Very easily controlled, hard to become overwhelmed. In this respect, the 2C-C of the tryptamine world.
- Euphoric, recreational, sexual.
- Music is absolutely gorgeous.
- However, can also be steered in an intellectual direction, and some pretty awesome self-discovery can be made.

4-AcO-DMT

- A serious tool. Nothing more, nothing less. Not a recreational chemical by any means.
- Powerful healing capacity, much moreso than 4-HO-MiPT. Trips are often very therapeutic or insightful.
- Very dark energy during the trip. Can become highly dysphoric.
- Again, like 4-HO-MiPT, capability for stimulating lots of insightful thinking, but it comes less from playful curiosity, and more from the sense that something is SERIOUSLY WRONG and you NEED TO FIGURE OUT WHY.
 
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I've tried 4-HO-MiPT, 4-HO-MET, 4-AcO-DMT, mushrooms, and synthetic 4-HO-DMT.

Honestly, I can't tell the difference between 4-HO-DMT and 4-AcO-DMT. The difference between these two and actual mushrooms seems to be purely related to the dry, crunchy biomass I have to ingest when I take mushrooms, which usually makes me feel kind of sick. Every trip is unique, of course, but, as far as I can tell, 4-HO-DMT and 4-AcO-DMT seem to have essentially the same drug effect. Broadly speaking, they have the power of 4-HO-MiPT, but substantially more "depth".

For me, 4-HO-MiPT had the intensity of the psilocin experience, with two primary differences. First, it came on much more quickly; one of the times I took it, I had finished coming up from an 18mg capsule within thirty minutes. It was really disorienting coming up that quickly. Second, it didn't seem to induce the same kind of opening of internal perception that psilocin does. If you're an outwardly-oriented person, you probably won't notice this, but it was crucial for me. It was like miprocin opened the same door as psilocin, but didn't quite push me through it like I was expecting. I've only taken it twice, though, and I seem to be in the minority when I voice my dislike for this compound, so I could have simply had a couple of strange reactions.

4-HO-MET was, again, very similar to psilocin. I never took a high dose, but I feel like it would be capable of inducing the same kind of alternate-reality experience that a high dose of psilocin can. If I were forced to point out a difference between the two, I might say that the visuals were slightly more subdued than psilocin for the same level of trip, but, again, this could just be my own idiosyncrasy.

Like you said, these drugs seem to differ less in their effects than the 2C-X compounds. They do each have their own quirks, but they all do basically the same "thing," whatever that is.
 
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speaking of 4-subs: is 4-MEO-MIPT anywhere compareable to 4-HO-MIPT?
 
hm. can't speak to that but I can say 5-ho-DMT is nothing like 5-meo-DMT...but this isa 4-subed tryps thread.
 
In my experience, 4-aco-dmt blew the others away in terms of depth, euphoria and intensity. All 3 of them are fun chems, but 4-aco-dmt is something special.

Sniffing more than 35mg is nuts! I highly recommend it if you have experience.
 
I've only tried mushrooms and 4-aco-dmt. Mushrooms feels more raw and nauseating body wise. 4-aco-dmt pretty much feels similar on your body as regular mushrooms, but with less nausea for me. It can still be intensely sedating and nauseating though.

Mushrooms seem to give me a more antsy, manic paranoid type feeling where as 4-aco-dmt it feels more clear headed and sedated. That's only my experience, they can both produce the same range of positve and negative effects and I think they feel very similar.
 
Guess I'm one of the few people who noticed unmistakeable differences in Psilocin and Psilacetin. Here's my comparison of the three (I'll throw in Mipracetin for kicks)..

Psilocin
- Lightest body load of any psychedelic
- Low doses feel like if the cleanest MDMA you ever had was only 50% pure, and this was pure. Natural ecstasy.
- Relatively short duration of 5-6 hours
- Can be felt within 10 minutes of oral ingestion and fully developed in just over half an hour
- Visuals and trip is not exactly like mushrooms... instead being closer to 4-aco-DMT (which is more like an extended sub-breakthrough DMT trip)
- No nausea

Psilacetin
- Very DMT like in higher doses, in medium doses is sort of like a hybrid of mushrooms and LSD, in low doses it once again resembles a low extended dose of DMT
- Closed eye visuals often involving basking in light, or a "womb" experience
- Feels like some rather holy stuff
- Generally light on the body but can cause a little nausea on the come up, and feeling stimulated once the trip has worn off
- Highly variable range of emotional responses
- Lasts a couple hours longer than Psilocin and takes a bit longer to kick in as well

Miprocin
- Very pleasureable body sensations, can be erotic
- Not much visuals in lower doses but when you take enough for visuals it's Persian visual madness
- Trip is very short and the peak might not last more than 2 hours in some cases
- In most cases fairly recreational although high doses can kick your ass

Mipracetin
- Lasts around 7-8 hours, again, longer than the hydroxy .. also taking slightly longer to kick in
- This chemical gives a mindstate of Godliness ... spiritual power ...
- Visually there is a lot of morphing, pulsing, waving. The visuals are very active and persistent.
- Low doses seem more like mushrooms than Psilocin, in my opinion. High doses are rather unique.
- A bit less transparent on the body than the other chemicals listed here, but still rating fairly well in terms of overall body load.


Hope that helps. 4-ho-tryptamines may have some similarities in a lot of cases but they are also many of the best psychedelics and worth exploring the differences, if you're into that kind of thing ;)
 
I've experienced the following compounds relevant to your inquiry: 4-AcO-DMT, synthethic psilocin (4-ho-DMT), 4-AcO-MiPT, 4-ho-MiPT, and psychedelic mushrooms.

The answer to your question about how it compares to psilocybin (4-PO-DMT) is, to my knowledge, under reported in common parlance, as 4-PO-DMT has only made the rounds as part of academically sponsored experiments so far as I know. I assume 4-PO-DMT, as a pro-drug of 4-ho-DMT, is qualitatively similar to 4-AcO-DMT, based on theory. I also assume you're identifying mushrooms as psilocybin (4-PO-DMT) in your post above? Mushrooms are natural, and thus are extraordinarily unreliable for making comparative subjective judgments insofar as there are variations in the proportions of the multiple essential active compounds concerned between samples. Using mushrooms as a comparative is problematic because their numerous active constituents are inherently highly variable between species and harvests.

If you're still curious about how 4-AcO-MiPT compares to psilocybin (4-PO-DMT) and O-Acetylpsilocin (4-AcO-DMT), consult the academic literature and the 4-AcO-DMT thread, respectively. I will add that the AcO versons of 4-sub tryptamines are typically reported as having a slower onset and having subjectively fewer and less intense peaks and troughs relative to their "ho" counterparts, which is expected -- as "AcO's" are theoretically metabolized into the more subjectively volatile "ho's" in vivo (here I'm assuming the AcOs are not mere prodrugs but are active in their own right independent of being metabolized into their ho counterparts, an assumption whose validity is still debated).
 
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this most paralells my e

TheAppleCore said:
IMO:

4-HO-MiPT

- Very easily controlled, hard to become overwhelmed. In this respect, the 2C-C of the tryptamine world.
- Euphoric, recreational, sexual.
- Music is absolutely gorgeous.
- However, can also be steered in an intellectual direction, and some pretty awesome self-discovery can be made.

I agree, the 4ho-sub strictly for"fun" seems to be the mipt if not diisopropyl or even possibly diallyl


4-AcO-DMT

- A serious tool. Nothing more, nothing less. Not a recreational chemical by any means.
- Powerful healing capacity, much moreso than 4-HO-MiPT. Trips are often very therapeutic or insightful.
- Very dark energy during the trip. Can become highly dysphoric.
- Again, like 4-HO-MiPT, capability for stimulating lots of insightful thinking, but it comes less from playful curiosity, and more from the sense that something is SERIOUSLY WRONG and you NEED TO FIGURE OUT WHY.
Click to expand...

i agree entirely, ive sampled a native aussie strain that had an identical feel to a heavy 4aco trip. 15 min comeup, 1HR full onset, ++++ next 4 hours, as conversion to psilo ocxurs, next 4 hrs are like a whole new world. the same goes for wet eats in excess.of 100g 10 whole fruiting bodies. just like the phosphate ester, it all converts to 4ho, but these.procecies are rate limited and i believe 4aco is most dominant in living fruiting bodies. as a related aside as evwr heard of a documented or not strain of austrailian p. cubensis that grow huge, literally over 250g apiece for the biggest wet ones i saw. but i reference a.trip, thatz closely rivals.a massive dmt.IV from this particular strain and believe my variant to be inclined to produuce the acetate, then phosphate, then 4-hydroxylaye. BTW, Im Phil, and Im sentient being in recovery, lol any imput on this?
 
Hello phil. Recovery for what? DMT and psilocin analogues can give press that 'reset' button (or 'overcharge' if you are Clinton's Russian translator) but you still have to reprogram the damn thing the next day.

As for the mushrooms themselves, they are God's flesh. It's been eons since I've had shrooms, recent experiences with pure psilocin reminded me of what these are capable of. 4-AcO-DMT...not so much...seemed a little more on the light side but all of my psilacetin trips were during opiate-using times so I am due for fresh perspective.

Welcome to Bluelight.

 
I've only taken an allergy test of my 4-aco-dalt, anyone care to add this substance to this cavalcade of 4-substituted comparisons?
 
Anyone who thinks all 4-substituted tryptamines feel the same is absolutely wrong. Obviously the onset, come-up, body high, duration, etc will be similar, and there certainly is a general 4-subbed trypt sort of headspace, but each of them is a unique chemical. I love 4-HO-MiPT! Actually gives just about the craziest visuals of any 4-subbed trypt to me (well, ok, it ties with 4-AcO-DMT). 4-HO-MiPT is very happy, far more euphoric than 4-AcO-DMT (which can be very euphoric, but often tends to take on a pretty serious or just very mystical tone- not a drug to be taken "for fun") or psilocin (though I've only had shrooms not pure psilocin). As with many tryptamines, I find 4-HO-MiPT to be sort of stimulating & "stoning" at the same time, though with a stronger tactile sense than other 4-subs. I can't really imagine having body load issues on it though, while on 4-AcO-DMT I can get ridiculously jittery (which is odd because it feels more sedate than stimulating). I also get a little jittery from 4-AcO-MET, so maybe it's an AcO thing....
 
i can compare 4-ho-mipt to 4-aco-dmt (which i've tried less), to mushrooms.

4-ho-mipt i will edit IamMe's and applecore's posts, because they said pretty close to what i want to say.

-More giggly/euphoric
- Extremely clean feeling, very little to no "body load," maybe a very slight headache on the comedown
-very nice tactile feelings

- nice pastel colored visuals and trails
-pretty easily controlled, hard to become overwhelmed. In this respect, the 2C-B of the tryptamine world.
- Euphoric, recreational, sexual.

- i wouldn't have commented on the musical aspect of miprocin...but it has been pretty good for music now that i think about it.

-come-up is very energetic and stimulating compared to 4-aco-dmt. come-up of both is pretty fast when powder is mixed in liquid and drank.
-energy makes me wanna "do stuff" but i find it hard to do much of anything sometimes - due to the vibrational aspect of it

-trip is quite short - about 4-6 hours for the whole thing. one of the only disappointing things about miprocin IMO :)


4-aco-dmt
- more introspective, deeper
- Clean but some transient nausea has been present before

-CEVs very similar to sub breakthrough DMT, OEVs not that prevalent for me

-more sedating, makes me yawn a lot
-higher doses can have me pretty much plastered to the couch - can't, or don't want to do anything other than lay and take it all in

-i've seen some very rough trips on 4-aco-dmt. so it's serious. miprocin may have that potential at higher doses, but so far...

-i find 4-aco-dmt to require a higher dose for me. maybe it's my batches. miprocin has satisfied me at less than 25 mg. usually i dose less than 20.


mushrooms p. cubensis i believe

-they are a very serious psychedelic. i have more respect and fear for them than any other drug, including my favorite LSD.

-can be nauseating, and "inebriating." they sometimes feel a bit like a drunken trip

-but they can be super fun and enjoyable too. i have less experience with these than the other two. and mostly when i was younger.
 
If you consider the whole spectrum of altered states then the 4-substituted tryptamines are all sitting in pretty much the same position. Sure there are clear differences between them but I don't think there are any fundamental differences in the kinds of experiences induced, just a tendancy for some of them to give certain types of experiences over others. To be clear no two trips are the same, I can take mushrooms two seperate occasions at the same dose and have vastly different experiences. This fact is often overlooked when people compare these compounds as often they were each only tried a handfull of times. Rather than consistently producing a unique high I feel that these compounds are merely more likely to give you a certain experience. For example 4-ho-met tends to give you a more social and giggly high, you can get an extremely similar experience with mushrooms or any of these other compounds but much less frequently. Conversly 4-ho-met is capabable of producing the introspective experience that you often get with mushrooms or 4-ho-dipt. I guess what I'm trying to say is that people seem to obssess quite a bit about the differences in this category when I think they all do essentially the same thing.
 
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