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Gibberings CXIII : A walk in the park

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The rate and extent of rectal drug absorption are often lower than with oral absorption, possibly an inherent factor owing to the relatively small surface area available for drug uptake. In addition, the composition of the rectal formulation (solid vs liquid, nature of the suppository base) appears to be an important factor in the absorption process by determining the pattern of drug release. This relation between formulation and drug uptake has been clearly demonstrated for drugs like diazepam, paracetamol (acetaminophen), indomethacin, methadone and diflunisal. Coadministration of absorption-promoting agents (surfactants, sodium salicylate, enamines) represents another approach towards manipulating rectal drug absorption, although this concept requires further research concerning both efficacy and safety. For a number of drugs the extent of rectal absorption has been reported to exceed oral values, which may reflect partial avoidance of hepatic first-pass metabolism after rectal delivery. This phenomenon has been reported for morphine, metoclopramide, ergotamine, lidocaine (lignocaine) and propranolol.
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http://www.ncbi.nlm.nih.gov/pubmed/1717195
 
^ yes Dan, it all depends on your definition of the word 'fine'. Your fine and Mugz fine may be two very different things :D

jancrow said:
I couldn't resist, sorry. Call it Friday fever.
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No one can resist a bit of arse entendre on a Friday night.

Mailmonkey said:
Pretty apathetic? Them comments seem completely one-sided.

I like how the Mail disables comments these days on canna stories where the overwhelming opinion is that it's a waste of time and money to be pursuing these cases....
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Yeah, i suppose what I meant is the antis were apathetic in that even they didn't bother piping up.
 
Mugz said:
I do believe in harm reduction and answering serious questions seriously mate, that's kind of why I modded a forum which is exactly designed for that, people asking drug questions and people giving drug advice.
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did you ever find it infuriating when people kept asking for advice then completely ignored it?

=D
 
yeah lol

ok bashed together 2 20mg lines from 2 different batches of MXE. not sure which is better, infact they're both pretty good i think. old pre ban stuff. just gone up the hoofer. been awhile, sure the feeling will be very recognizable soon. dont wanna do too much, last time i woke up with my heart racing, no idea why. i wanna be glowing for days

apologies in advance if i type some fucked up stuff lol. tis pretty odd
 
Mugz, it was actually regarding my morphin IR 10s. I've plugged them in a solution many of times, but was caught short at work today thinking its either eat it (which as u know is a waste of morphine given its low bioavailability). So I wondered whether poking it up my arse woulda been worth it. But now you mention the midaz, might try that too.
 
Mailmonkey said:
did you ever find it infuriating when people kept asking for advice then completely ignored it?

=D
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I don't think I have ever actually explicitly ASKED for advice, I may have hinted at needing it due to the dire situations I've gotten myself into recently, but I don't think I ever outght asked for advice.

I agree though, it can be completely infuriating when people keep asking for advice and then ignore it.
 
Mugz said:
I

it can be completely infuriating when people keep asking for advice and then ignore it.
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Very

etiz, a lil bit of vodka and some MXE down me, now it looks like im gonna miss out on a decent night in exeter. ahh well fuckit, tomorrow is the main one. cant handle 2 nights of liver abuse that well anymore these days. and neither can my funds
 
Mugz said:
I don't think I have ever actually explicitly ASKED for advice, I may have hinted at needing it due to the dire situations I've gotten myself into recently, but I don't think I ever outght asked for advice.

I agree though, it can be completely infuriating when people keep asking for advice and then ignore it.
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True, technically you might not ask for much advice.

But you come on here and tell everyone you've basically lost your mind from taking drugs yet you're going to keep taking them.

How do you expect people to react? Should they ignore you or laugh at you? A plea for help need not be framed explicitly.


EDIT I've shat solids finally, in case anyone's interested. I still feel like the living dead. It's a horrible disease.
 
I'm doing well today and have taken some positive steps, some sideways steps and gained some self control in an area where I thought I had none, was as simple as removing myself from the same room as the offending substance and I'm not interested in it anymore, and the other life based reasons like dad, aunt, etc.

I do regret the madness that I posted on here and the drug use that caused it, it's not gonna happen again, I really do appreciate the advice, but I didn't ask for it really, but as you said what else did I expect. I'm getting things together, slowly, but surely.


Nice one on the solid shitting, where was it on the stool chart? Crohns?
 
Mugz said:
Nice one on the solid shitting, where was it on the stool chart? Crohns?
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Crohns is probably generous. It was bit like I imagine bat shit to be. It beats the litres of brown phlegm I've been pumping out though.

I'm glad you've taken some positive steps, by the way. Kinda jealous actually.

edit: I've been a naughty boy and got hold of some MXE. Might have to give it a wee shot tonight to cheer myself up!
 
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