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The Big & Dandy Medication/Supplement Interaction Thread

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Why are you allowing your doctor to numb your mind with all that nonsense? Are you in that bad a way?
 
Risperidone is a 5HT2A antagonist and will kill your trip, Depakote has also been reported to block the effects of psychedelics, and it's possible SSRI's like paxil might dampen the effects of a trip a bit.

Cannabinoids work by a different pharmacological mechanism, and thus weren't affected like psychs were by your medical regimen.
 
CrAzY HaCkZ said:
I'm on 10mg paxil, and a 2mg of risperdal and im gonna start depekote tomorrow, is depekote, paxil, or resperdal blocking my trips? ive been trying every other week on different shroom amounts and different batches. I DID TRIP on 2 grams of shake my head was spinning and my thoughts were racing i had to take a xanax and chill out.. and shower lol please answer about ALL my meds please thanks so much! i literally have NO trip after taking 4 grams dry and i just got off risperdal yesterday like yesterday and today were my first 2 days off it, could i trip tonight ?
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Risperdal (risperidone) will block psychedelic drugs from exerting their pharmacological action at serotonin and dopamine receptors. People who take antipsychotics typically feel nothing or very little when they take psychedelics, even if the dose is high.

You may need to wait a week or so until the risperidone is fully out of your system. It would be worth waiting that long, rather than trying to trip when there may still be pharmacologically significant levels of the drug in your system. Also be aware that when coming off of a drug, the receptors that the drug targeted will be more highly sensitized than usual. That means that you may be more sensitive to psychedelics than normal immediately after withdrawing from the risperidone.
 
You should not discontinue your medication to take psychedelic drugs without first discussing it with your doctor. I presume you are not just on them for a laugh.
 
Transform said:
You should not discontinue your medication to take psychedelic drugs without first discussing it with your doctor. I presume you are not just on them for a laugh.
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im on risperdal because i was telling my doctor that i keep seeing space ships like ufos in the sky so she thought i was having unusual thoughts or hallucinating, im on paxil for general anxiety which that pill doesn't even do anything they HAVE to prescribe a SSRI when prescribing a benzo to intentionally make it look like its a temporary solution and the SSRI is the permanent solution, ive been in the crazy business along time i know how it works. and now that shes giving me depakote because i have panic attacks at random times so she thinks my mood is going up and down, does anyone know if depakote will block shrooms from working? because now i wont be on paxil or risperdal.
 
There used to be a big and dandy thread for medication/drug interactions, if anyone has an old link to it that would be amazing. It was really informative.
 
Ketamine, Methoxetamine and Levo-Thyroxine/T4/Thyroid Hormone 4

Someone I know is taking Levo-Thyroxine/T4 and in the patient information leaflet it mentions that you should talk to a doc'/pharmacist if you're taking/going to take ketamine.

What exactly is the problem with ketamine and hypo-thyroidism/taking T4/Levo-Thyroxine?

Is this more of an anesthesiologist's concern than a recreational ket'/MXE user problem?
Someone I know is depressed/suicidal and has seen the anti-depressant effects of ketamine and MXE and would like to try it. They are also on SSRI's.

Thank you in advance!
 
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It can cause hypertension and tachycardia, some googling shows. While not having clinical data to back it up, the anecdotal reports of interaction were seriousness enough that they put a specific warning on there. I'd be weary combining the two, if you feel you must, maybe it'd be alright if you were using Jamshyd's medicinal ketamine regimen, or otherwise tried it with low doses. Going for strong recreational effects, especially K-hole level doses, seems downright contraindicated given available info.

MXE won't be any better, if anything it'll be worse, given its more stimulative nature.

Your acquaintance should reconsider their current medicinal regimen (with their psychiatrist/doctor, of course, I'm just sticking my nose where it doesn't belong in my suggesting this) if their depression is still severe and they have suicidal thoughts. SSRIs aren't the way to go for many people.
 
Apparantly i read on the leaflet that comes with my bros levothyroxine medication NOT TO USE KETAMINE

and also i read that it makes the ketamine more toxic to our bodies for some reason when on Levothyroxine

ketamine + thryoid medications = A BIG NO NO
 
Never Knows Best it'll be MXE that the person I know is taking. Would a 40mg intranasal/sublingual dose be ok as a one off or are the hypertensive/heart risks way too high? :\

Also Never Knows Best do you have a link to Jamshyd's ketamine dosage stuff? Thank you! :)
 
Gaz_hmmmm said:
Never Knows Best it'll be MXE that the person I know is taking. Would a 40mg intranasal/sublingual dose be ok as a one off or are the hypertensive/heart risks way too high? :\
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Doing some more looking, it doesn't seem that straight up stims are contraindicated, so my assumption was wrong, I guessed that MXE would be worse due to it's (supposedly) stronger DRI effects (and NMDA antagonism raises BP/HR all on its own), but that doesn't matter apparently.


Anyway, I'd say start'em low, like say 15-25mg, then go up from there, making sure s/he reacts normally. The evidence for this problem is anecdotal, so there may have been some other factor involved that lead to the hypertension/tachycardia. Hopefully this is so, and s/he'll be able to use normally.



Also Never Knows Best do you have a link to Jamshyd's ketamine dosage stuff? Thank you! :)
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Ask and it shall be given to you: http://www.bluelight.ru/vb/threads/372731-Jamshyd-s-Medicinal-Ketamine-Regimen!-(V-1-5-UPDATED-11-22-10)
 
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Does anyone know if there is any problem with mixing Amitriptyline with 25I-NBOMe?
Someone asked me that the other day and I didnt have a clue.
 
Is LSD contraindicated with Clonidine? I was prescribed the stuff for insomnia for some reason and never really took it, but I'm thinking if i want to sleep after my upcoming trip I might take some. Now, as far as I can tell there shouldn't be a problem, Clonidine being just a pretty mild alpha-2 agonist, but I want to be extra cautious.
 
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