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Opioids half lives and opiates

H

heavyriffer

Bluelighter
Joined
Sep 28, 2011
Messages
167
Location
Montreal, Quebec
would the half life of one drug like valium, clonazepam or flexeril taken for a few days affect and interact with opiates, hydromorphone, oxycodone ect on a day where the other wasnt taken? e.g sat-mon flexeril, tues hydromorphone
 
Valium and Klonopin will definitely still be in your system..... Flexiril has a relatively shorter half life than both, Valium being the highest and Klonpin coming in next. But if you are dosing any three of these drugs for a first time/ not habitually taking them and having them in your bloodstream already, then dosing with an opiate the next day, I doubt there will be much interaction at all, maybe, MAYBE with valium if you're taking a larger dose, but if you're keeping it moderate, I doubt there will be significant interaction. Just based on my experiences.....
 
Note that half-lives are not the only thing to consider. Half-lives are just an average of how long it takes for half of the original drug to be out of a person's system. A half-life not necessarily the same thing as duration of effects, some drugs have active metabolites with much longer half-lives than the original drug, and everyone'e metabolism is different. Some effects, such as respiratory depression, can last longer than the noticeable or therapeutic effects (like decrease in anxiety, muscle relaxant, anti-convulsant, "high", etc).

So I'm assuming what you mean is would taking a long-lasting benzo or other CNS depressant pose a danger when taking an opioid 24 hours later? It really varies depending on the benzo (or other drug) taken, the dose, the dose of the opioid you're going to be taking, your metabolism, how long you've taken the benzo or other drug, possibly which opioid you take, and (especially) your tolerance to both benzos (or Flexeril) and opioids. As for the drugs you mentioned:

Clonazepam has a duration of effects of around 12 hrs and a half-life of 18-50 hours, and diazepam (Valium) has a duration of effects of around 6-8 hrs and it's main active metabolite has a half-life of 36-200 hours, so I would be concerned about taking an opioid the day after these. If you are going to do this, first start with a much lower dose of the opioid than usual, since you have no idea how much of an effect the benzo will have on it.

Cyclobenzaprine (Flexeril) is not a benzo, it's a weird drug and we don't really understand how it works yet, so it's possible that it could have more adverse effects with opioids than just CNS depression. It also builds up, reaching a steady state after 3-4 days with levels 4 times higher than if you only take it once. The half-life for a single dose is 8-37 hrs. Duration of effects seems to vary a lot. Again, I would be concerned about taking an opioid the day after. If you are going to do this, first start with a much lower dose of the opioid than usual, since you have no idea how much of an effect the cyclobenzaprine will have on it.

TLDR: Yes, they might interact with opioids even a day later, so if you're going to take opioids I would take less than usual.
 
I took a 1mg Kpin last night and today I took half of an OC 30mg (the original formula) and felt "lighter" I'm not sure if maybe my tolerance is going up, but you can still get high, just take a little bit more than what your used to and it will work no problem.
 
^Do not take more opioids than usual after using benzos. Opioids and benzos synergize with each other, increasing the effects like sedation, respiratory depression, and therefore the dangers.
 
does flexeril have active metabolites like valium? what if you had a tolerance to opiates in the first place like 4mg of hydromorphone spread out in 2mg doses with about 4-5 hrs between each dose?

To add to this the only other significant thing i found concerning this is when taken at 3x doses a day for a few days(5-10mg) does it accumulate in the body. so would this influence anything? say that was taken 1x a day for a few days?
 
Last edited:
heavyriffer said:
does flexeril have active metabolites like valium?
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I'm sorry, I don't know. It's harder to find this type of info on Flexeril.

what if you had a tolerance to opiates in the first place like 4mg of hydromorphone spread out in 2mg doses with about 4-5 hrs between each dose?
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Having a tolerance to opioids is going to reduce the risks of taking it after another CNS depressant in comparison to not having a tolerance. I would try taking less hydromorphone than usual to be on the safe side though.

To add to this the only other significant thing i found concerning this is when taken at 3x doses a day for a few days(5-10mg) does it accumulate in the body. so would this influence anything? say that was taken 1x a day for a few days?
Click to expand...
Yeah, 1x a day is better than multiple times a day, but it would still accumulate and therefore you would have higher blood levels and it would take longer to leave your system compared to just having taken it once.

The risks of taking 2 CNS depressants a day apart is of course going to be a lot lower than taking them at the same time, but it's impossible to know in advance how much it will add to the CNS depression so it's best to start with less of the opioid than you normally would.
 
JeromeA215 said:
I took a 1mg Kpin last night and today I took half of an OC 30mg (the original formula) and felt "lighter" I'm not sure if maybe my tolerance is going up, but you can still get high, just take a little bit more than what your used to and it will work no problem.
Click to expand...

This is the WORST advice you could possibly offer. I strongly suggest you edit your post in case someone reads it, follows your advice, and dies like so many others who have combined benzos and opiates.
 
thanks for the responses and info gathered, i too had a hard time finding the info on Flexeril. Usually i seen potentiation and taken two CNS depressants at a time threads. like alcohol-benzos, benzos-opiates and so fourth and that i guess varies in danger to how much dose of each was taken and tolerance to either. me i see it as just dangerous regardless but this time it was what if one taken yesterday and the other tomorrow.
 
My dad is extremely knowledgeable about drugs, especially benzos and methadone but he's used Flexeril a lot. If you have questions still, PM me them and I will forward them to him.
 
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