Naltrexone and opioids

[cook]

I'm on naltrexone 50mgs a day.

If I want to skip a dose and get high instead, what will happen? Will I get precipitated WD's the next day when I load myself up with naltrexone again when I still have some active opioids in the system?

 

[hemdroids]

I depends on your tolerance, what agonist(s) you take, and the dosage. If you still want to get high don't take naltrexone.

 

[Swimmingdancer]

Naltrexone's effects last for a really long time. I'm not sure if skipping a day would be long enough to be able to get high off opioids. The half-time of opioid blockade by naltrexone ranges from 72 to 108 hrs. 50 mg of naltrexone has been shown to completely block the pharmacologic effects of 25mg pure intravenously administered heroin for at least 24 hours.

In people physically dependent on opioids, naltrexone will cause precipitated withdrawal symptoms. As far as I understand, if you are not currently dependent on opioids, it should not cause withdrawals. So if a non-opioid-dependent person were to use an opioid once, then use naltrexone the next day, it should not cause withdrawal symptoms.

Naltrexone blocks the effects of opioids by competitive binding at the opioid receptors. The blockade can be overcome by using huge doses of opioids, but this can be dangerous, and can result in side effects such as excessive symptoms of histamine release (swelling, difficulty breathing etc), because naloxone does not block the side effects of opioids which are not mediated by the opioid receptors. It is also dangerous because it is hard to gauge the dose of opioids that will produce the desired effects yet not kill you, and you can also feel fine then slip into an OD as the naltrexone wears off.

Of course, if you are on naltrexone, there are other reasons why you shouldn't use opioids. Presumably you are on the naltrexone because you wanted to quit opioids. It's quite likely that you might skip your naltrexone, use an opioid, then end up skipping the naltrexone the next day too so you can use, and so on. It is very easy for your brain to trick you into using for longer than you intend, for example you could rationalize it by saying to yourself, "I didn't really get a proper high because the naltrexone was still partly blocking the effects, I just want to feel a good high one last time".

NOTE: If you are going to use while on naltrexone, a short-acting opioid which minimizes the duration of respiratory depression is safest (do not use long-lasting opioids). The dose should start very low and be gradually titrated - do not assume you will need a high dose and therefore start with with one.

 

[cook]

In people physically dependent on opioids, naltrexone will cause precipitated withdrawal symptoms. As far as I understand, if you are not currently dependent on opioids, it should not cause withdrawals. So if a non-opioid-dependent person were to use an opioid once, then use naltrexone the next day, it should not cause withdrawal symptoms.

Ok, I hope this is correct because I'm about to find out soon.

NOTE: If you are going to use while on naltrexone, a short-acting opioid which minimizes the duration of respiratory depression is safest (do not use long-lasting opioids). The dose should start very low and be gradually titrated - do not assume you will need a high dose and therefore start with with one.

What do you mean by this? I mean do you think it is safe to use the same dose that I have started with without tolerance while on naltrexone? Because I have read stuff that says the use of naltrexone "sensitives" the receptors so even lower doses of opiods should be used after the treatment but I don't know if this is true. Anyway if I experienced difficulties when using my DOC (skipping doses) I could always take the naltrexone because it works fast even orally (unless I black out) and that should cancel the respitory depression.

Don't worry, I am going to of course check these things from my doctor before proceeding, I just wanted some opionions and create discussion.

 

[Swimmingdancer]

What do you mean by this? I mean do you think it is safe to use the same dose that I have started with without tolerance while on naltrexone? Because I have read stuff that says the use of naltrexone "sensitives" the receptors so even lower doses of opiods should be used after the treatment but I don't know if this is true.

I meant that even though after 24 hrs the naltrexone should still be at least partly blocking your receptors, don't assume this and take a high dose. I'd start with a really tiny test dose, because you really have no idea where your tolerance will be or how much of a blocking effect the naltrexone will still have. As you said, I've also heard that naltrexone treatment can possibly even lower your sensitivity to opioids to below where it was when you first started using opioids (not sure how long after last taking the naltrexone one would be able to notice this effect though). You can always take more opioids if it's not enough but you can't undo it if you take too much.

Anyway if I experienced difficulties when using my DOC (skipping doses) I could always take the naltrexone because it works fast even orally (unless I black out) and that should cancel the respitory depression.

I would NOT count on being able to self-administer naltrexone in case of an OD. In my experience, when someone has OD'd on opioids, they don't realize they are overdosing. In fact I've never seen or heard of anyone realize they were in danger or have time to do anything about it, nor did I when it happened to me. You just pass out and stop breathing. That's why it's always best not to use alone and to always start with a smaller dose than you think you will need, especially after any period of not using opioids, naltrexone therapy, trying a new opioid or getting a new batch of an opioid if it's a street opioid. Not sure what opioid and ROA you are planning on using, but with heroin it's pretty much impossible to self-administer an antagonist if you OD.

 

[T. Calderone]

Swimmng. said it all and I don't recommend trying to skip your naltrexone to get high.
There is a reason you're on it so don't do it. The opiates are not worth it. Stop already

 

[cook]

In my experience, when someone has OD'd on opioids, they don't realize they are overdosing. In fact I've never seen or heard of anyone realize they were in danger or have time to do anything about it, nor did I when it happened to me. You just pass out and stop breathing.

I don't IV, I only use oral opioids (pod tea, pharmaceuticals). I believe there is more chance to do something when OD'ing orally versus IV where you really don't have a chance unless someone shoots narcan for you. But I've never OD'd so I don't know really.

 

[THCified]

How does administered naltrexone feels like? Is it giving any effects, or is it just blocking opioid receptors in the brain? Thanks a lot!

 

[Kronos]

Dude, Donmt. Make sure your dully off the naltrexone before you do it. I was on naltrexone 50mg a day and missed a few days to get high, on the last day took bout 700mg of dhc and some other stuff and took 100mg 2 days later. Worst 3 days of my life ensued, then worst week after that. You been through the pain on WD? Imagine that, condensed into one, in so much physical pain vimot and shit shooting out of both ends your head hurts so so much, you feel worse than death, worse than any rattle.

I cant describe my experience properly, just do not mix the naltrexone or opiates. Stop taking it permantly then get high, or just keep taking it and stay clean off em. Do not mix, it wont end well andif you end up anything like me its as bad as being tortured

Edit: To the guy above, naltrexone give no effects at all, no high, nothing like that, it just stops you getting high of ant opiate/opioif no matter what dose

 

[cook]

How does administered naltrexone feels like? Is it giving any effects, or is it just blocking opioid receptors in the brain? Thanks a lot!

I don't feel it at all, it seems to block the opioids and nothing else. I currently take only 12.5 mgs because it is more than enough, 50 mgs is a dose for a horse for opioid blockage.

 

[Swimmingdancer]

Lots of people do get side effects from naltrexone though, and some aren't able to feel their endorphins.

 

[cook]

I feel just great all the time, I don't know why but the talk that naltrexone "makes you feel like shit" etc just isn't true. It's a great medication.

 

[Swimmingdancer]

I feel just great all the time, I don't know why but the talk that naltrexone "makes you feel like shit" etc just isn't true. It's a great medication.

Just because it isn't true for you doesn't mean it "isn't true". Everyone reacts to it differently. As with any drug of course.

 

[cook]

Just because it isn't true for you doesn't mean it "isn't true". Everyone reacts to it differently. As with any drug of course.

Yes, but I meant I've seen so many posts of people assuming that antagonist must make them feel like shit (and it will if they're dependent of opiates course), even they never tried it, just assume so. In my experience, it could not be farther from the truth. I actually feel rather euphoric when the dose starts to wear off.

 

[THCified]

^ Perhaps you're suffering from a mental disorder, like the borderline personality disorder? I heard that people get good effects off naltrexone when suffering from this specific mental disease.

That's because i asked about it.

I'm really interested in naltrexone and will speak with my doctor about it in the next days. So far, MXE is the best medication i came across. I tried various things but nothing really helped, except MXE in lowish doses. But i think those two don't mix well with each other and tbh i don't want to use MXE on a regular basis.

 

[cook]

^ Perhaps you're suffering from a mental disorder, like the borderline personality disorder? I heard that people get good effects off naltrexone when suffering from this specific mental disease.

Yes I have some kind of mental disorder but it isn't borderline, more like avoidant personality -type of thing but it isn't exactly that either. Where did you hear that persons with borderline get good effects from naltrexone?

 

[THCified]

^^ Really interesting.

I read it on Wiki, but i just saw this information is only listed on the german wikipedia page. It has been mentioned in a book called "Lehrbuch der Psychotraumatologie" by Gottfried Fischer and Peter Riedesser.

They say it's off-label used for people with borderline personality disorder with positive feedback of the test subjects.

 

[cook]

It could be due to kappa-receptor antagonism which naltrexone also does. At least it it has been linked to possible mechanism of another kind of antidepressants etc. mental stuff.

 

[THCified]

I'm really thrilled what my doc says about it. Best thing is, naltrexone doesn't make you physical dependend with prolonged use and it doesn't built a tolerance. Could you tell me some more about the effects it's giving you, everything would be of interest for me.

I can literally see people popping out of the bushes telling me i'm delusional if i say that, but MXE works also for me, in fact, the afterglow makes me feel just normal - and with normal i mean like one should be when sober. When i'm sober, i suffer almost any kind of symptom which borderline personality disorder can give you. Sometimes i'm mostly normal but then i'm a total mess, if not by itself, then as soon as i'm in a stressful situation.

It's not like i'm crazy, i've a normal life, friends, family, work and that all that, i'm living a very decent life and within that even healthy, as far as nutrition and body composition goes, but i'm a bit special and i learned it the hard way, which wasn't that nice.
But as you know, what doesn't kill you, makes you stronger

So, that's the reason why i came to naltrexone in the first place. I don't wanna take a dissociative on a regular basis, so this could be an alternative. For now i'm trying to change, as strange as that sounds, myself with continued use of low dosed MXE. Perhaps with some kind of therapy i can alter some brain functions. See it as when other people take LSD or Shrooms for example, to expand their mind. I'm trying to change mine with MXE, which has shown some utterly phantastic results.

 

[cook]

I'm really thrilled what my doc says about it. Best thing is, naltrexone doesn't make you physical dependend with prolonged use and it doesn't built a tolerance. Could you tell me some more about the effects it's giving you, everything would be of interest for me.

Well, I take it at night. When I wake up in the morning I usually feel just great, kind of have some kind of buzz you would get from low dose opioids. After few hours this passes and the rest of the day I'm feeling quite normal. This is the only clear effects I've noticed, I wish it would last whole day though.