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Dosing a female newcomer - Medical Advice ?

A

Achten

Bluelighter
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Jun 19, 2011
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My GF (20 yo) is interested in trying MDMA.

She has absolutely no drug experience (hasn't smoked pot) and has only been under the influence from alcohol once.
She likes being clear more than being suppressed.
She's just now beginning with "meditation", or as I call it "conscious living". (paying attention to colors around us, living in the now, enjoying Nature and the Sun, ..)

Aside from that, she has been sick two years ago. Recovery is almost over but she still is taking L-Thyroxine for her thyroids. I read this medication could have an influence on heart medication, and since MDMA puts a reasonable but considerable pressure on the heart, hence my question.

She has an intuitive mind and is open to new experiences.

She weighs +/- 55kg

I was thinking about dosing
T0h = 60mg
T1h OR T1h30 = 20mg

Prior to this, I want to give her an allergy test. Would 10mgs be ok ? Or should I try more ?

The experience is planned for New Years Eve so there's plenty of time to prepare.

Questions I'd like answered:

Is the 10mg okay as an allergy test or what is more appropriate ?
Is the L-Thyroxine a problem ?

I'm browsing the mega-threads too but I'd like an answer here as well please !

edit: I like to believe I'm not stupid but also not medically trained. Is L-Thyroxine the same as L-Thyrosine ? The latter has a thread here but somehow I don't think it's the same ? Or is it ?
 
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very sensible dosing.
hmm my brother is on L-Thyroxine i am not sure of the interactions yet, there is also a member on here who would know the answer to this. Im not sure myself.

All i know is when you take L-Thyroxine you shouldn't take ketamine, he pointed this out to me for some reason, but yeah it makes the ketamine more toxic to the body. It says it on the leaflet that comes with the meds.

id say 80-85mg for a 1 dose new timer,
 
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I'd say that is a little too conservative in the dosing. I'd shoot for 100mg, then if needed, 20-25mg redose at the very least two hours in. I've been lucky enough to dose many first time rollers =D at least of said rollers are female and this always seemed to work best, this is just my opinion though. Wish it was my first time again.
 
80 / 85 mgs is pretty low (even if Erowid states common dose) as long as your testing your gear and comfortable with what your taking then I would personally suggest aiming a bit higher. The sweet spot for a lot of people is around the 90 / 120mgs!
 
Bearlove said:
80 / 85 mgs is pretty low (even if Erowid states common dose) as long as your testing your gear and comfortable with what your taking then I would personally suggest aiming a bit higher. The sweet spot for a lot of people is around the 90 / 120mgs!
Click to expand...

Ok, how would OP feel if the female newcomer spewed everywhere and had bad coming up

VS a mild experience.

There's a reason i stay on these boards. . . . .
 
i did some research on this about a year ago because my friend wanted to try 2c-i and was worried about the iodine. what i came up with was that since thyroxine is for hypothyroidism, which has a possible symptom of a slower heart rate, its not really a problem unless the person has a weak heart to begin with. on the other hand, if they had hyperthyroidism, then they should stay away from all stimulants including caffeine due to possible heart interactions. my friend ended up taking 2c-i and loved it, no medical problems at all

p.s. - she was taking thyroxine
 
You can easily get that same experience from drinking alcohol for the first time, as well as smoking weed. Some people get sick after they drop, nothing you can do about that.
 
Dmytry said:
i did some research on this about a year ago because my friend wanted to try 2c-i and was worried about the iodine. what i came up with was that since thyroxine is for hypothyroidism, which has a possible symptom of a slower heart rate, its not really a problem unless the person has a weak heart to begin with. on the other hand, if they had hyperthyroidism, then they should stay away from all stimulants including caffeine due to possible heart interactions. my friend ended up taking 2c-i and loved it, no medical problems at all

p.s. - she was taking thyroxine
Click to expand...


there is no iodine in 2C-I, it's a chemical used to produce a chemical reaction that creates new chemical bonds... by the end process, anything toxic should have been removed... if it's a qualified chemist.
 
Darksidesam said:
Ok, how would OP feel if the female newcomer spewed everywhere and had bad coming up

VS a mild experience.

There's a reason i stay on these boards. . . . .
Click to expand...

We really have no idea how the OP would feel if 'his' subject was either over or under dosed! I was simply stating that 80/85 mgs is a pretty low dose - when you consider that in the US a' pokeball' (that when tested was 90 mgs) was rated a great pill . TBH I was really only stating 5 / 10 mgs more than your suggested dose!

Your reason for staying on these boards... is just as valid as my reasons for not staying on these boards... !
 
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Thanks for the replies !

My stuff is tested and "pure". (Marquis turning dark purple/black in one second, while it stated it could take 2minutes to change color.)

I want her to have a good experience, of course. But I'd rather dose too low than too high. There's lways a next experience...

I dose my male friends, being 75-80kg with 115mg and everyone has a blast, but it definetly shouldn't be more. I myself dosed 130mg, being 89kg.
This is about 1.5mg/kg bodyweight. During my reading I've come accros various statements stating that girls need less of a dose, not only because they generally weigh less (that should be taken care of with the mg/kg bodyweight) but also *because* they are girls.

That's why I was thinking dosing relatively low for her, like 1-1.25mg/kg bodyweight. Maybe I should go for 75 + 25mg. I plan on dosing 125mg + 40mg myself and I'd like us to be "equally" under the influence.

Anyone else has any thoughts about the L-Thyroxine ? I think her thyroid is underactive, that's what hypo-thyroidism means, right ?
 
Darksidesam said:
Ok, how would OP feel if the female newcomer spewed everywhere and had bad coming up

VS a mild experience.

There's a reason i stay on these boards. . . . .
Click to expand...

Probably not that great at the time but I say go for a good dose 1st time always! Spewing will be soon forgotten.

I see people mention mild MDMA doses and I alwawys think the same; if you are looking for something mild try taking something else.
 
I've had my fair share of high-dose psychedelics. I was shown the real world, the Truth. Now I only use medium doses to meditate/have an OBE. Different strokes for different folks, I guess.
 
FlippingTop said:
Probably not that great at the time but I say go for a good dose 1st time always! Spewing will be soon forgotten.

I see people mention mild MDMA doses and I alwawys think the same; if you are looking for something mild try taking something else.
Click to expand...

It's not the really the spewing part, its just i have seen people first hand suffer badly from anxiety on comeup, so much so that it lingered after the experience and it's not exactly what i would like to think people remember when taking mdma.

But yeah, mdma is not a mild drug haha,

In saying that though, i have never been sick from any drugs whatever or alcohol. I came close once when i had some 'Vanilla' Ketamine lol
 
Folley said:
there is no iodine in 2C-I, it's a chemical used to produce a chemical reaction that creates new chemical bonds... by the end process, anything toxic should have been removed... if it's a qualified chemist.
Click to expand...

...folley, i know theres no free iodine in 2c-i, but i had to prove to her it wouldnt leave the ring

achten, a normal dose would be safe for her with her medication. there would be no metabolic or enzymatic interactions. like i said, it would only be a problem if she had hyperthyroidism but her medication is for hypothyroidism
 
^ Even if it was the worst chemist in the world and somehow he left such a toxic precursor in his product, the doses of 2C-I are so low that it probably wouldn't matter... iodine is needed for our bodies to produce certain chemicals after all.

I agree though, the chloro and iodo rings used to make me quite a bit more nervous than sometime like methylene or bromine.. but really there's nothing to worry about with such well known chemicals. It only gets more risky when you get into the abstract RCs, if I remember correctly there is a variant of MDPV that lets off chlorine gas when vaporized.
 
Yeah, that's the only thing I'm kind of worried about, the comeup anxiety. That's why I want to give her some confidence with the allergy test.

And also still kind of in the dark about the L-Thyroxine, anyone ?

edit: I've never done it myself but I've heard of people aborting bad trips (mushrooms etc) with diazepam or something similar. Is this possible with MDMA too, and what/how much do you propose ?
 
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Lets face it the come up anxiety lasts a very short time - as a first timer taking any substance they are going to feel anxious so tell them about it upfront. IF they are willing to have the experience then leave it at that, you can really only advise them of the effects and then its up to them (do not get too caught up with this or YOUR going to have a shit time all night thinking ' are they ok ' ' I hope they don't hate me as I gave them this drug' etc).

You really do not 'trip' on MDMA in the same way you do shrooms etc - I have personally found that if somebody is having a bad / negative effect from taking MDMA then simply removing them from their setting is much easier than giving them something else to take. For example - if your in a house setting and the person is freaking out / having a bad time thinking people are talking about them, simply leave or move to another room and stick some funky music on. They may be reluctant to move at first but tell them that YOU need to leave etc. Or if you can change the music or whatever they are watching on TV - sometimes people can get sort of stuck in a loop with what they are watching /hearing and its directly linked to what they are thinking / feeling. Slower / Faster music from what was being played - nature or brightly colored programs etc.

If you take the quick exit option of simply / chemically falling asleep then they will have a negative memory attached to the experience!
 
True, anxiety is a part of the experience, and she knows it will be part of it.
Still, I'd like to have some safety belt when the shit hits the fan ;)
 
'IF' it hits the fan not 'WHEN' - if you go into this with a negative mind set your going to have a bad time which could in turn spoil her experience. Its horrible when your sitting wrecked off your face and some overly concerned person keeps shaking you saying are you ok, are you feeling alright, eventually you start to think - Am I ok, why are they asking, Am I acting strange etc.

Knowledge is the best thing to take into any experience as its not always possible to give somebody another chemical (either to pick them up or bring them down). If your at home then - once you have established what the problem is act accordingly. Talk to them first and find out the problem - if they are hot -cool them down, if they are cold warm them up (gently though never go from one extreme to another). Music freaking them out - change it, TV disturbing them change it, turn it off etc. If they are still really freaking out then reach for the benzo's or sleeping pills - give them half a pill or less and tell them it will help.

In a club / rave setting then it can be a bit harder - try going for a walk, get away from the main dance area where everyone is going nuts and find a chill out area. If she starts to freak out then do not overreact, keep it jovial and light and she will come around. I
 
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