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RCs The Methiopropamine N-methyl-1-(thiophen-2-yl)propan-2-amine (MPA) Megathread

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I'm really interested on which brain receptors MPA works on.
I still wonder if it works on seretonin at all - personally i never felt any seretonin action at all...

To the best of my knowledge, all of the major monoamine neurotransmitters (so, notably, serotonin, dopamine, noradrenaline etc.) are affected to some extent. Seems fairly likely that it's a releasing agent of dopamine and noradrenaline and that it's also a MAOI and competitive MA transporter antagonist (based on a combination of anecdotal and experimental evidence and speculation that I've come across). Although the serotonin element is almost invisible, it's probably there somewhere even if only as a byproduct of its role as a MAOI. Overall, the effects are very probably an increase in levels of several neurotransmitters with dopamine and/or noradrenaline being hit substantially more than the other monoamines.

It doesn't make for great reading tbh. I really need to quit using this stuff.
 
So in laymen terms MAOIs are bad or what? I know SSRIs are bad and shouldnt be mixed with any drugs. Can you elaborate on MAOIs and what not to take with it.

Any other relevant information would be appreciated.
 
Coveman: Check out the post above, that's all the relevant info! :)

NeighborhoodThreat: Worryingly, there seems to be some evidence to suggest that MPA is itself an MAOI as well as having a regular stimulant action through dopamine and/or NA release and some other action that I can't remember right now. Only recently have I realised just how dirty this shit is.

I'm quitting imminently and I'd advise all regular users of this stuff to consider slowing down or doing the same. Also I'd implore all users, especially of the MPA/MDAI combo, to stay far, far, far away from 2-AI. It is not an MDAI substitute as some vendors are claiming. It's actually another stimulant and if you take it with MPA, you are at a very real risk of ending up in hospital. You could be, and it doesn't seem unlikely that you would be, stacking perhaps 4 or more actions which all increase dopamine and noradrenaline levels. Naturally, the vendor I interrogated about this didn't give a shit about the neurochemistry or the potential outcomes but I thought I'd try anyway cos I can see people making the news again with this combo.

Take care all.
 
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Great, thanks for the supplied information.

I'd just like to add that there seems to be a new batch of MPA being made which makes it come out crystal like. I received some MPA this morning that was in its new form, so I emailed the owner of the company I use explaining that perhaps they might have sent me out the wrong chemical. He assures me that what I received was infact MPA.

Baggy on the left is what id normally receive and the one on the right is the new version.
http://s10.postimage.org/acixw1zmh/IMAG0239.jpg

Below is a copy of the email I received.

Edit:

Email removed due to request from owner.
 
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I had one hypertensive crisis with this stuff, also with Methylone one time. Didn't know what i ate wrong but i haven't consumed anything at all besides the substance itself (and of course a bit weed in the evening). It was very frightening.

What food can be especially responsible for something like this?
 
2 more grams paid for but cnt get till tuesday grrr why dnt decent vendors ship on a saturday buggers were open but dnt ship :) really cnt wait , a 4day binge planed ruffly maybe more as i can afford another 2 bragging over but this stuff must of changed got less cut or is getting mixed with something as i would never of believed i would be counting the days to the next baggie of this stuff :)
 
would there be of any use of 5-meo-dalt with mpa or would mpa completely smash the dalt to pieces so no effect from dalt
 
^^
I can only speculate but either the mpa would kill the buzz from the dalt or visa versa. I can't see why you'd want to mix the two?
 
Just to see what its like..different combos. Coveman that pic on the left looks nothing like what I've got. Mine isn't pure white but smokes up well but leaves a brown line on the pipe afterwards. The vendor I got it off has now taken it off the list for purchase..seems very suss. Time to find new vendor me thinks. Plus their tight asses../end of rant
 
Great, thanks for the supplied information.

I'd just like to add that there seems to be a new batch of MPA being made which makes it come out crystal like. I received some MPA this morning that was in its new form, so I emailed the owner of the company I use explaining that perhaps they might have sent me out the wrong chemical. He assures me that what I received was infact MPA.

Baggy on the left is what id normally receive and the one on the right is the new version.
http://s10.postimage.org/acixw1zmh/IMAG0239.jpg

Below is a copy of the email I received.

Edit:

Email removed due to request from owner.

one on the lefts what i normal get as well we will see tuesday if mine have to moved to this new one
 
intelligentmind :-

The pic on the left is what I have been receiving for my vendor for the past 6 months. Its a off-white-tan powder that seems a little wet and clumps together. However when vaped I have always been left with a tan/brown substance like you've mentioned.

Could you take a pic/explain in a little more detail on what you've received?

For the record, I tried the new batch of MPA last night (The somewhat crystalline version) and from what I can tell its absolutely MPA. It has that plasticy taste to it on the drip and kept me awake from 6pm-8am from 2x50mg lines.
 
intelligentmind :-

The pic on the left is what I have been receiving for my vendor for the past 6 months. Its a off-white-tan powder that seems a little wet and clumps together. However when vaped I have always been left with a tan/brown substance like you've mentioned.

Could you take a pic/explain in a little more detail on what you've received?

For the record, I tried the new batch of MPA last night (The somewhat crystalline version) and from what I can tell its absolutely MPA. It has that plasticy taste to it on the drip and kept me awake from 6pm-8am from 2x50mg lines.
Yes its sort of off white there's a few small balls & small different sort of shapes the rest is powder but its not crushed completely.
 
Yes its sort of off white there's a few small balls & small different sort of shapes the rest is powder but its not crushed completely.

How do I upload a pic? It tastes sort of salty but really bitter as well. Hard to explain but if someone can tell me how to upload pic much appreciate
 
I use a site called http://postimage.org select the picture you want, press upload and when you're given the links you can either select the direct link or have it as a thumbnail (#1, I think)

Also :- You shouldn't need nor should be able to crush your MPA, it comes far to wet and you'd just end up with a clump of powder. I'd think bout getting a new vendor mate.

Foolsgold :-

I did upload a copy of the email the owner sent to me however he kindly asked me to remove it due to confidentiality which I completely understand. But he said basically that he has found a new lab that has found a way to make it purer (I think he said 97% pure) and that the impurities is what caused MPA to clump together. Which I have to admit is completely true from my exp last night, the new batch is a lot easier to handle and although he said it would be 'stronger', he also said it would only be 1-2% so its not noticeable.

I mentioned earlier that I tried it last night and a 100mg dose which is the norm for me atm split into 2 lines kept me awake, alert and quite chatty with my friend for 12hours give or take. It was a nice exp that was made more enjoyable from the cans we bought earlier.
 
Yep I will try find a different vendor. Especially since they've taken their mpa off the shelves - something not right there. EDIT - I'm jealous I want the crystal instead of this god knows what I'm breathing into my lungs..sorta does job tho but the brown markings are a pain to clean not even with a torch do they come off.
 
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No that doesn't sound too good, perhaps they've had complaints or realised that what they've been selling is either not MPA (It doesn't taste salty at all) or is a very unpure batch. MPA is quite common, although I don't know where you're from but it shouldn't be too hard to find.

Best of luck.

While I remember don't forget that picture.
 
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