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Opioids Acquiring norbuprenorphine from subutex

M

magicpunkmcfly

Greenlighter
Joined
Oct 16, 2010
Messages
9
Location
TN
I currently have about 4mg of subutex, a bottle of st john's wort, a bunch of .5mg xanax and half a bottle of dxm capsules. What I'm trying to do is get full opiate agonistic (sp?) effects by converting the subutex to as much norburprenorphine as possible as I've researched that that is a full opiate agonist as opposite to the partial agonist that burprenorphine is as I'd like to feel some euphoria and a high as opposite to the just opiate effects minus the euphoria that plain old subutex gives you. Now I am in no way opiate naive so no need to worry about me overdosing and I'm not currently physically addicted to any other opiates so I don't think I'll have to worry about precipitated withdrawls either. Now about an hour two hours ago I took 2mg of xanax and and hour ago I took about 1050mg of st john's wort but I'm afraid its not a standardized extract so I'm not sure if I took enough to get the 3A4 inducing effects of the st john's wort to hopefully convert the subutex to norbuprenorphine. I also intranasally ingested about half my 8mg bupe about 15 min ago. now I am wondering if I did this method correctly to get the most recreational usage out of my bupe (I only have one unfortunately) or if I should go about using a different route for administering the rest of my bupe. And if st. john's wort is a 3a4 inducer in the stomach would snorting the bupe completely bypass the stw's ability to induce to 3a4 into converting most of my bupe into norbupe? (Note to mods this is also like my second time posting here so if I posted it in the wrong place if you could kindly redirect to the right place to post it it would be greatly appreciated.) Also another question, would it be of more recreational value to shoot the rest of my bupe or would the fact that shooting bypasses the liver completely render the effects of the sjw useless?
 
I'd really appreciate anything suggestions or info from people with experience or knowledge on this subject, and the quicker the response the more convenient it would be more me. Thank you all for your help in advanced.
 
In my knowledge the full agonist -effect of buprenorphine can be felt only at doses below ~1-2mg when the buprenorphine itself doesn't block the metabolite too much. I don't think your enzyme tricks make a lot difference here.
 
Is the norbuprenorphine not just as powerful at binding to the opioid sites as buprenorphine? I've read various reports of people using various dosages of st. john's wort to increase amount of norbuprenorphine metabolized. Were they just feeling placebo affects or what? I'd like just to know the best possible dosage and timing of dosages for the sjw and xanax to get the most euphoria out of my subutex. And also would it be worth shooting the rest of it or 1-2mgs of it? Would that produce any kind of rush or euphoria of any kind even if its just briefly?
 
Norbuprenorphine's binding affinity is lower than buprenorphine's, this is why you need a low dose to not occupy all of you receptors with the original bupe and leaving some room for the norbupe. This is the theory. I am not familiar with the st. john's method but I have enjoyed buprenorphine greatly at low doses and it feels just as full agonist as the real agonists.

Shooting bupe does not produce a rush and is very questionable. Plug it for nearly the same results, also your veins thank you for that.
 
Shooting bupe doesn't give you a rush, it just comes on faster, obviously it takes a good 15-20 seconds before you start feeling it strong
 
i used to be able to get high from buperenorphine and the higher the dose the higher i got up to 12mg then i think i hit the ceiling effect now it just keeps me well
 
So all those threads about people taking st john's wort with subutex and then getting really schmashed are just bullshit? I read a few reports one where they took sjw like an hour before they dosed their subutex and another one who said they took the sjw like an hour after they dosed and they said they felt a profound difference. And so shooting bupe does nothing but bring it on faster and I assume make it last shorter? But otherwise you get just as high as any other ROA? by the way what ROA has the highest bioavailability for bupe?
 
IV has the highest bioavailability but unless your going to use i micron filter shooting pills is a bad idea i've done it lots of times and am ok but it's just not worth the risk
 
mrflowers00 said:
IV has the highest bioavailability but unless your going to use i micron filter shooting pills is a bad idea i've done it lots of times and am ok but it's just not worth the risk
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I almost never shoot up, ( something like once every 3 months because I don't like having track marks anywhere and I've never successfully been able to hit myself so I'm not tok worried about the dangers of it since I hardly ever do it at all and although I'd love to use a micron filter I have no debit/credit card to order one online and have no idea where to buy them locally
 
Sterifilt/Micron filter is a MUST when shooting pills, don't even think about doing it without if your health means anything to you. Even with filtering it's still a bad idea but a whole lot safer. Bupe works rectally way better than insufflated imo.
 
Well besides the whole being unsafe without a micron filter does it just hit you faster and feel stronger and have a more intense peak? Does it last shorter tho? By the way I tried the st john's wart thing and it did seem to work definitely more euphoric than if I'd done it by myself but I also took $120 dxm and 2.5mg xanax an hour before
 
IV bupe has a little bit more faster onset than the other ways but there is no rush and the effects are shorter in duration. It's just not worth it. Maybe ur xanax played a bigger part than the st john thing on that potentiation.
 
magicpunkmcfly said:
So all those threads about people taking st john's wort with subutex and then getting really schmashed are just bullshit? I read a few reports one where they took sjw like an hour before they dosed their subutex and another one who said they took the sjw like an hour after they dosed and they said they felt a profound difference. And so shooting bupe does nothing but bring it on faster and I assume make it last shorter? But otherwise you get just as high as any other ROA? by the way what ROA has the highest bioavailability for bupe?
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IME it is bullshit. I fact, I've read some evidence (though it was all theoretical discussion really) that norbupe would really be too dangerous to take in any recreational dosage.. Check out this existing thread on the topic Norbupe.
 
The fact remains that opi-naive people will get better effects for analgesia at small doses rather than at larger doses. I don't think you'd consider norbuprenorphine "dangerous" but it certainly won't be as nice as a full agonist. Kind of like abusing diphenoxylate or something.

A lot of "potentiators" that supposedly increase production of norbupe are psychoactive in their own right.
 
magicpunkmcfly said:
I almost never shoot up, ( something like once every 3 months because I don't like having track marks anywhere and I've never successfully been able to hit myself so I'm not tok worried about the dangers of it since I hardly ever do it at all and although I'd love to use a micron filter I have no debit/credit card to order one online and have no idea where to buy them locally
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if you've never been able to hit yourself what makes you think shooting a pill without proper filtration is a good thing? if anything that makes it worse.

unless you're talking about having someone else hit you.
 
Yes I was talking about someone else hitting me but I just took another 90mg dxm and 3mg xanax and tooted the other 4mg of my bupe and am gettin quite a bit of euphoria right now :) oh yea I also took an Aleve and some benadryl too so yeah I'm feelin pretty good off this bupe and I'm a daily roxy/hydro/ various other opiates user
 
sekio said:
The fact remains that opi-naive people will get better effects for analgesia at small doses rather than at larger doses. I don't think you'd consider norbuprenorphine "dangerous" but it certainly won't be as nice as a full agonist. Kind of like abusing diphenoxylate or something.

A lot of "potentiators" that supposedly increase production of norbupe are psychoactive in their own right.
Click to expand...

Right, well, what I've always wondered was whether the euphoria experienced at lower dosages of buprenorphine is due to norbuprenorphine having receptor space to occupy, or whether norbupe really isn't responsible for much of anything, and that what's really going on is that at low dosages, (under the ceiling dose) the effects of buprenorphine are just more pronounced each time you dose, as your receptors are not saturated with the shit-just like how when you do your first shot of heroin in the morning, it's much stronger as the period between the injection before bed and the one in the morning is the longest time gap (creating a stronger rush).
 
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