• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

NBOMe orally with MAOI?

slownerveaction

slownerveaction

Bluelighter
Joined
Oct 31, 2010
Messages
79
Location
California Republic
Is anyone aware of experiences combining an oral NBOMe derivative with oral MAOI? Totally random hypothesis, but since NBOMe appears to be destroyed by first-pass metabolism a la DMT, maybe it could be made orally available by the addition of an MAOI. An easy first test might be harmala alkaloids, since they're reversible MAOIs with a decent track record...any thoughts?
 
I don't think NBOMe are destroyed by MAOI - their metabolism is pootrly characterised though and mixing them with MAOI drugs is liable to end poorly. Look at LSD+MAOI for example.
 
Have you had much experience with LSD and an MAOI sekio? Does it work? Some people claim it does, some don't. I tried it once and wasn't successful.
 
Never tried it myself (LSD+MAOI), but reports are pretty scattered. I know a psychotherapist used that specific combo & reportedly it gave things a darker, earthier feel IIRC. This is far from first hand info so treat accordingly.

Personally, i vaped 750µg 25E a few hrs after smoking a MET & harmine joint. I couldn't really say if there was any additive effect, or if i had significant enough levels of harmine to really make much of a difference. Regardless i would advise against using MAOI's & NBOMe's as there just isn't really enough known to do it safely.
 
Upon further consideration, as monoamine release probably plays very little in the experience of LSD and other "selective" 2A agonists. Although combining the 2 is still not really advisable due to the uncertain response you will have - there may be unexpected potentiation.
 
any major dude said:
Never tried it myself (LSD+MAOI), but reports are pretty scattered. I know a psychotherapist used that specific combo & reportedly it gave things a darker, earthier feel IIRC. This is far from first hand info so treat accordingly.
Click to expand...

Yeah that was the secret cheif - but I wonder if that was the effect of the harmalas which are kind of psychoactive themselves rather than a straight MAOI. Moclobemide with LSD didn't appear to work.
 
Do not do it. Very big risk of serratonin syndrom as all the activity has not been recorded. Mescaline is a safe phenethylamine to mix with harmalas, but mdma is not. I also know 2c-b is recommended to avoid MAOI including harmala. I did a lot of research on combining NBOME with harmala alkaloids or maoi and found no experience reporrts, but one negative experience and the general consensus was it is not a good idea.

If you do dose very small of both the MAOI and the NBOME (thresh hold 10-25 mcg dose even) for your first test and only after researching the receptor activity and type of maoi that your compound is. Also have a trip sitter who is sober with enough knowledge to look you over and do some test to figure out if calling 911/going to the hospital is necessarily or not.

Bottom line it is not recommended and if you do decide to do it be safe.

edot: Someone did accidentally prove the nbome is active in 100 mg oral on accident. He said he would not repeat this mistake though. You could try taking oral nbome doses increasing by 3-5 mg per test. Still not recommended as it is a new substance. When you test these things you are using your body and life as a lab testing animal essentially.
 
Last edited:
Very big risk of serratonin syndrom as all the activity has not been recorded
Click to expand...

Except that serotonin full-agonist drugs like LSD, mescaline, psilocin don't cause appreciable levels of monoamine release compared to MDMA. Even you yourself say, mescaline+MAOI works but MDMA does not. IIRC none of the 25x compounds have appreciable affinity for SERT.

The real risk is not therefore serotonin syndorme but instead just out-of-control potentiation.

You are very right that it's still not a wise idea to jump headlong into this combo.
 
PEA's and maois are just sketchy territory regardless if they are monoamine releasers. Mescaline is stimulating, as is lsd, combining them with a maoi seems risky for that reason alone. I can personally say maoi's & mescaline is not dangerous per se, but it did not feel entirely safe, hardly scientific but ymmv. Trying to make nbomes orally active w/ a maoi seems reckless and dangerous imho.
 
sekio said:
Except that serotonin full-agonist drugs like LSD, mescaline, psilocin don't cause appreciable levels of monoamine release compared to MDMA. Even you yourself say, mescaline+MAOI works but MDMA does not. IIRC none of the 25x compounds have appreciable affinity for SERT.

The real risk is not therefore serotonin syndorme but instead just out-of-control potentiation.

You are very right that it's still not a wise idea to jump headlong into this combo.
Click to expand...

I mentioned it because it may function like MDMA phenethylamines and other sorts by forcing the release of extra serratonin. I am very uneducated in this field and mostly just a self researcher, but I don't think I am making a mistake here. There is a serious health concern along with the potentiation of effect to a powerful experience one is unprepared for.

Edit: The negative experience was a little blurb someone posted on the DMT-nexus. I remember them saying they got a serious headache, but can not remember if it was when mixing harmalas or smoking harmala laced changa on 25i-nbome. I will double check.

Edit 2: "After everyone gets some changa, I decide to load some enhanced leaf, apparently forgetting that there would liekly still be harmalas in the bowl. DO NOT MIX HARMALA ALKALOIDS WITH THIESE SUBSTANCES! Right after exhaling my headache kicks into high gear, full-blown migrane which inhibits me the rest of the night. After sitting for a minute to wait for any terrible effects to start I get up and go back to the group and report the terrible headache. The kid on Jurema takes a hit of changa and goes DEEP, purging everywhere and falling into the far-visionary state. We cheer him on and explain to his girlfriend (I guess) that he’s going to be fine he’s just really in deep. It is decided that a bit of Alcohol is in order, as we have found this class of substance to go with alcohol for whatever reason. Not to get drunk (unless you want) but the second half of a high-dose of this stuff is rather edgy and it helps with that. "

https://www.dmt-nexus.me/forum/default.aspx?g=posts&m=373466

He was on 25c-nbome... He did drink alcohol after though, which is not a good idea with maois, but he did seem to be thinking about the risks and tried to keep his dose low.

Personally as far as LSD and MAOI I never had issues combining them besides the effect seeming weekend, but I had a diluted vial. I have yet to try with a full dose... I think...
 
Last edited:
Ismene said:
Yeah that was the secret cheif - but I wonder if that was the effect of the harmalas which are kind of psychoactive themselves rather than a straight MAOI. Moclobemide with LSD didn't appear to work.
Click to expand...

That would certainly make sense given the available data. I could see that being more likely than MAOIs potentiating LSD through other mechanisms.
 
You must log in or register to reply here.
Top