What can I expect from sudden withdrawl of 800mg effexor ir after taking it for 3yrs?

EcHo EcHo

Bluelighter
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I'm in a bind, limited income, just lost my apartment and had to move back in with my mom and stepdad. They DO NOT understand medication or my bipolar I disorder and cluster B personality disorder. I semi-know what to expect from such an abrupt stop of such a high dose of instant release medication. They simply believe it's all in my head and I'm making up these symptoms because they want me to help do yard work. Can someone please go into detail about what will happen when the withdrawal symptoms start and what my parents can expect over the next 8 days? I know, however they simply tell me I'm not a doctor and brush me off like my 12yrs of dealing with this condition is meaningless. I chose advanced drug discussion because I need them to take this seriously, as my health will be greatly impacted. Someone, anyone, everyone, please respond with something and I could also use advice on how to get them to take something they read from an online site seriously. I wanted to live on the street rather than move in here, however my family (not mom and stepdad) has begged me to stay here instead. I pray for numerous quick and thorough responses.

Thank You,
Paul
 
Disclaimer: If your parents won't listen to a doctor, they won't listen to random drug forums on the net.

Withdrawal from high dose SNRI drugs is well documented. I suggest showing your parents at least the wikipedia article on discontinuation syndrome. The very best thing you can do is not discontinue the medication all at once. Getting "off" of SNRI drugs should be done stepwise, especially with high doses, to give time for the blood levels to slowly decrease.

W/D may lead you to feel very, very uncomfortable. "Brain zaps", seizures, twitching, general malaise are all common to some extent. Some people handle W/D better than others. But at such a high dose it won't be easy. I would expect you to be bedridden and possibly in need of medical support within 48h of discontinuation.

The symptoms are widely variable in description and are of unknown etiology; common descriptions include dizziness, electric shock-like sensations, sweating, nausea, insomnia, tremor, confusion, nightmares, and vertigo.

Sudden discontinuation of venlafaxine (brand name Effexor) has a high risk of causing potentially severe withdrawal symptoms. Even missing a single dose can cause symptoms of withdrawal. The high risk of withdrawal symptoms reflects venlafaxine's short half-life as well as its effect as a dual uptake inhibitor. Discontinuations have a tendency to be significantly stronger than the withdrawal effects of other antidepressants including the tricyclic antidepressants, but are similar in nature to those of SSRIs with a short half-life such as paroxetine.

Symptoms of discontinuation are similar to other antidepressants including irritability, restlessness, headache, nausea, fatigue, excessive sweating, dysphoria, tremor, vertigo, irregularities in blood pressure, dizziness, visual and auditory hallucinations, feelings of abdominal distension, and paresthesia. Other non-specific mental symptoms may include impaired concentration, bizarre dreams, delirium, cataplexy, agitation, hostility, and worsening of depressive symptoms. Online help groups consistently mention withdrawal from venlafaxine as triggering dreams of a particularly distressing and hellish quality.


Before you do any dose adjustments, phone your doctor. Tell him what's up. Since you have a mood disorder, withdrawal from your meds is only one thing to worry about - the other is a relapse of your condition.

It is probably wisest to continue taking your usual dose of medication behind your parents' back, to avoid a very messy situation. Sudden disconinuation of your meds is not going to help.

ADD -> TDS. Advanced drug discussion is for academic discussion, not pharmacy advice.
 
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Dude is that a typo or are you really on almost a gram of effexor a day? I cant even begin to think what you're in for, im on 75mg and if i miss a dose im all fucked up.Good Luck man, you need it.
 
thats not good at all some ppl have psychotic episodes from a discontinuation of ssri's. here is some info i found about it
Discontinuing selective serotonin reuptake inhibitors (SSRIs) may
induce a syndrome wherein the main neuropsychiatric symptoms are dizziness,
shock-like sensations, anxiety, irritability, agitation, and
insomnia. These symptoms usually develop 1 to 7 days after either abrupt or gradual
discontinuation (1-3). Antidepressant discontinuation may also induce
mania, mainly reported with tricyclics and monoamine oxidase inhibitors (MAOIs) but
also observed with SSRIs (4). Acute psychosis has been reported in
previously nonpsychotic patients following abrupt discontinuation of the MAOI phenelzine
 
800 mgs?? For real? What doc would prescribe that? I'd taper way slow, especially from that amount. I am on 150 and a few hours after missing a dose I get dizzy, sweats, shocks.. I couldnt imagine from a higher dose. I can't take more than 150 as it feels like I'm manic, and i inly have anxiety/ panic.. I didn't think Effexor was good for bipolar though? Good luck!
 
It's going to be hard abruptly coming off this type of medication. When I was prescribed effexor (a much smaller dose) sometimes I would forget to take it. I would get a strange feeling and start crying for no reason. Then realise I didn't take my meds that day and when I re-dosed I felt fine. That was from missing one single day! You're on a big huge amount of effexor and to suddenly quit is not good for you.

Wish your parents were more understanding of your condition. Agreed with above posts. Tomorrow get on the phone with your doctor and explain what's happening. Maybe you could taper your dosage or he could prescribe something similiar that's less expensive. Either way you don't want to be sick.
 
WOW!! Thank you everyone for the responses. My parents wouldn't even come to my computer, much less read any of the posts y'all left. I thank God that my Dad is understanding of my condition and knows what would happen if I suddenly stopped as he's seen it before and that was only three days. I read all of your comments but no, it's no typo, 800mg a day & 100mg of pristiq as well. Klonopin is my side effect killer and seroquel as needed for help sleeping. I'm doing no illegals or alcohol, just as an fyi. Low dose Effexor starts off as an snri and at this level it's what I truly believe, and feel, is an sndri. For those of you that take the IR form of the drug I'm sure you know what can happen if you don't eat a bite or two of something before taking it, that weird feeling is something I don't suffer from on an empty stomach. I can't stand the taste of them though. If I do eat something it's a few table spoons of peanut butter after taking the meds. The only real serious side effects I've suffered, for the most part daily, are dryness of my mouth and that awful taste as well, loss of appetite, the ability to lose a few lbs within an hour due to sweating, constipation, major head rush/dizziness/seeing what I call black shooting stars/fainting if I get up too quickly, and passing out if I get comfortable during the day coupled with insomnia some days. I only know of one other person to take 800mg of Effexor IR and she created a webpage where she blogged about it, unfortunately I can't find it, and she described it as a hellish nightmare for the most part. I have a drug history that most people don't believe, that's the reason for this insane dosage with Pristiq to boot. I've been seeing the same psychiatrist and psychologist for 9yrs now and been with the same practice for 12yrs. I usually check myself into the hospital about once a year, sometimes twice a year, to take a drug holiday and see where I stand and if I should change anything. The first ssri I took was Zoloft, over the course of a year and a half went from 50mg a day to 250mg a day, then it just stopped working. I stopped it cold turkey and on day three I thought I was going to die. Which is why I set some Effexor IR aside two weeks ago because I saw this problem being almost a certainty. The Pristiq saved my ass on withdrawal symptoms b/c I took my last dose this morning and it was only 200mg, but the last week was a little rough, especially the last two days. Went to a movie with my mom and she had to wake me up twice and I never realized I'd shut my eyes. Making a sandwich when suddenly my fingers want to make a fist and my arm wants to fly up in the air, mustard incident, lol. I've considered ECT treatments just to give my body a break for a few months or so, taking just 200mg of Effexor IR a day causes me to heal slowly and something like a simple mosquito bite will stick around for weeks and even months. I can tell the Effexor is back in my system because I'm still typing and have something to talk about for every dollar of debt ($16,000,000,000,000.00) my country has accumulated.


Last thing I'll say, my mom and stepdad don't believe in bipolar disorder, they don't believe in medication withdrawals that could be life-threatening, and they don't believe in me. I would rather live on the street than live here, and planned on it, however my dad begged me not to. Tonight my stepdad gave me an ultimatum, finish about 10hrs of work in the back yard by tomorrow's end or he would drop me off where ever I wanted him to. I had a heat stroke on July 4th because I'd drank 5 1/2 16oz 8% by volume Steel Reserves/211's and was dehydrated and didn't know it. Temp hit 105'F that day from what I was told in the emergency room when I came to, I know this is a bunch of drama however it's a little interesting to me and I feel it might be somewhat intriguing to others so I'm sharing it. I remember walking to the store the morning of the 4th but not my walk back home. Heat exhaustion quickly led to a manic episode and I left a path of destruction I don't remember causing that covered three floors of my apt building then walked 3 miles down a freshly paved road and a very busy highway. I'll let y'all imagine what I did on that walk b/c I don't know myself.
If I go manic from the heat tomorrow in the backyard I feel sorry for plant life and pray I don't injure myself on accident, the work involves a weed eater, machete, and hatchet, muscle too of course. If any of you would like to know how it goes just hit me up here on this thread and let me know, I'd be happy to share the story and possible dangers of what I really do consider to be an SNDRI.

May the H2O stay in me and the benzo stay with me,
EcHo =o)

PS, there may be typos n such cause I'm not going back to proof read all of this "quick reply"
 
Damn that steel reserve will do that to you. eww that's nasty beer. I have major yardwork that needs to be done as well. We have invasive trees that grew like crazy bending the fence and messing up the yard. We can't hardly walk through the backyard anymore. But when you can't afford to pay the landscaper to cut them, you have to do it yoursef. Sucks man.

So do you think your dad will help you out financially with getting your meds?
 
Damn that steel reserve will do that to you. eww that's nasty beer. I have major yardwork that needs to be done as well. We have invasive trees that grew like crazy bending the fence and messing up the yard. We can't hardly walk through the backyard anymore. But when you can't afford to pay the landscaper to cut them, you have to do it yoursef. Sucks man.

So do you think your dad will help you out financially with getting your meds?

Oh yes, my dad bought them and brought them to me last night. He knows my meds aren't just something I want to take, they're something I have to take. The side effects from this shit I don't want but the benefits far outweigh the risks and side effects. Even when I had the heat stroke, in which my meds played a big factor, my doctors (yes plural) still feel this is the best "cocktail" of meds for me. I just can't get overheated. I've been on disability for 10yrs now, even got my first check four days after filing (long story). But I actually love doing yard work. Especially when I get to take a Gerber Gator 18" machete and a old school hatchet with me to take down some trees and clear paths in the back yard. Letting anger out this way is safe, natural, and very effective =o)
 
Update

My dad got me the medication, however my mother decided to push as many buttons as she could in a blitzkrieg attack that I truly didn't see coming. Now I have until Sunday to find another place to go, the thing is, I never wanted to come here in the first place. My dear sweet loving mom tells me that my Effexor IR (Venlafaxine HCl), Klonopin, & Seroquel are drugs I want to take because I'm "addicted to pills," in her opinion. However the Pristiq (Desvenlafaxine HCl) I'm taking is nothing like any of the other three and isn't really much of a medication, b/c she takes it herself along with Trazadone and at one point Elavil. I'm not sure if I'm bitchin right here b/c she's got problems and won't admit it (11 scripts in the medicine cabinet), or b/c she acts, & speaks to others, as if I know nothing about the 35 or so psych meds I've taken in the last 12yrs and therefore calls me a liar to everyone she speaks to about the topic.

Thank you to whomever moved this to the dark side forum, I'm going to take some Seroquel and relax, or sleep since I have too much klonopin in my system. Maybe I'll get to a level of sleep where I can lucid dream and spend a few hours living a joyful life where I can fly around all I want and destroy the masses that have been turned since the zombie apocalypse started. If I couldn't control my dreams I'd go nuts. Anyone know of a/any good anime movies/series worth watching, I'm 32yrs old, and a site better than Netflix?

Life is like a hot pepper, what you do today might, burn your ass tomorrow ~Be Like Water~
EcHo §¤§
 
800mg/daily?!?! Surely that's a world record right there.

I'm on 150mg/daily and withdrawal symptoms involve some of the worst nausea I've ever experienced, coupled with dizziness, headaches, and *brain-zaps*.
 
im with you amino....i was on 150 a day and it made me worse so im on day 2 of peroxiate? (not sure if thats what its called) but 800mg! thats 4 x the max dose. goodluck with it all mate. Echo and forgive me if im being forward but when i was on 150 a day I couldnt pee properly (my bladder was full but it took ages to pee) and i couldnt orgasm. I would hate to think what 800mg does.All the best for you tho and if your family arent there for you then bluelight always is.
 
What can you expect from that sort of withdrawal?

Suicide. DON'T DO IT.
 
800mg? That doctor should be reported to the college of physicians in your region a.s.a.p. Only the most severe cases should get that dose and they need to be under hospital supervision!!

I can only share my story with you. As a teenager I was put on high dose paxil, 120mg. When I tried to get off it I had withdrawals, and it was before modern pharmacy even admitted that it was addictive. My psychiatrist basically tried to tell me I was crazy, but he switched me to effexor because he felt it might not be addictive. Instead, my body couldn't process effexor and I became seriously ill, on top of having withdrawals from the paxil.

Eventually I got fed up with being told it was psychosomatic, so I started tapering my own dose. Even though I was down to 10mg, eliminating the last 10mg was hell. I went into full on withdrawal that lasted for 2 weeks. The only thing that took the edge off was pot.

I'll never take an SSRI again. They are addictive. If your parents don't believe you and your doctor is unsupportive, then you might have to take matters into your own hands. But do it very incrementally. You're on a very high dose so your tapering is going to take a long time, probably half a year or more.
 
Perseverance vs Insanity

800mg a day is A LOT of Effexor IR, and when my doctors and I decided to add 100mg of Pristiq along with it every day I spent three weeks in hell... My September of 2012 is one I'd like to forget. When we, my doctors and I, knew that it was time to reduce how much I was taking, ignoring their instructions, I did it too fast; 200-400mg reduction a day. To put it simply I just cut the dose in half or by 1/4 each day depending on withdrawal symptoms. Last Tuesday I drank, yes I'm a little hard headed, however I was fine, until my drunk dad decided to start an argument with me. I did the right thing by walking away from the situation and going to my next door neighbors house. Unfortunately my uncle Jerry was there and he's a really bad person, to put it shortly, and with the mood I was in I walked into Jodi's house and saw Jerry standing there, which is when I promptly walked straight up to him and bitch slapped him in the face so hard he hit the ground. Then reality set in, oh shit why did I do this here at Jodi's house. Keep in mind I wasn't worried about Jerry at all, aside from him standing back up and I let him get a few punches to my face. Mistake on my part, he's already beaten his girlfriend that night and was high on crack as usual, owes me money, owes my dad money, has recently stolen from both of us, and then a few punches turned into a few more until it was too many to count. I took him down to the ground and put him in a position where I could have broken his neck easily and told him to stop moving and listen or I'd break his neck and not care about it. He stopped fighting back. I apologized and told him to leave and he agreed, as soon as I let him go he left. He went straight across the street though to my dads' house, I stayed sitting on the floor of Jodi's house talking to him and apologizing for letting that happen at his house. I don't know what took place between my dad and my uncle Jerry, but after a few minutes of talking to Jodi we both walked across the street to my dads' house and my dad was standing on the front porch with his shotgun, loaded, and he told me not to come any closer or he'd blow a hole through me. That was the point at which the back breaking straw was placed upon me. I never missed a step, I walked straight up to my dad and put the end of the barrel right between my eyes and said, "I was 16yrs old the first time you did this to me dad and I was scared to death, now that I'm 32yrs old I want you to pull the fucking trigger, but wait, you don't have the balls to do it." Reality left again and I started walking to the I-65 overpass, listening to my dad on the phone with Jerry, screaming at one another, until I was too far away to hear them. I sat down on the cement rail staring at traffic. I had thousands of things going through my head all at once, it's 8 blocks from my dads house so I guess that's why he pulled up in his truck. The police pulled up shortly after and I still stared at the traffic below and only three things were going through my mind, my 4 1/2yo daughter, what it could cause/create for the traffic and people below, and that it was MY choice - no one else could make it but ME. My wife was killed in a wreck 2 1/2yrs ago, our parents are insane, literally. Insanity: doing the same thing over and over again and expecting different results. I was so lost in thought staring at the traffic I didn't even notice the two cops that pulled me off the railing. One even punched me in the side of the head, not sure why, probably because he thought I would fight back or stress or who knows what. My dad saw him hit me and started yelling at him, which is when reality set back in and I told him to get back in the truck, he did because he realized he was really drunk, however he was still really mouthy towards the police officers. The cops realized that I wasn't struggling with them and I was trying to tell my dad to let it go, which is when they began to be nice to me. The one that hit me even said, "Now I understand why you were sitting on the railing." My face wasn't swollen too much yet and it was dark outside so I didn't think I'd sustained much injury from my legs being drug across the top of the cement railing. When the paramedics arrived, and there was light on my face, the way the officers were treating me changed drastically. The one that hit me felt awful, I could tell from the way he was acting. He apologized several times and everyone (paramedics & police) told me to check myself into the hospital and don't let a single person know I was there or how to get in touch with me.

I'm only sharing that story because it was the Effexor IR that caused it all, 4 beers included over 5 hours didn't help by any means, but I'm definitely one to give every detail so please know that all four were called, "King Cobra," with an alcohol content of 8% at 16oz each. AND THIS IS IN CAPS FOR THOSE THAT THINK ALCOHOL, EVEN A TINY AMOUNT, DOESN'T AFFECT & EFFECT YOU. ESPECIALLY WHEN ON MEDS LIKE SSRI'S, TRICYCLICS, A-TYPICALS, MAOI'S, AND REALLY EVERYTHING ELSE FROM LORTABS TO ASPIRIN TO VIAGRA TO VITAMINS.

I've been in the psych ward of Brookwood Hospital so many times I can't count them all, at least 16-18 times. For anyone that's been in a psych ward, aka mental health facility, relaxation therapy is the only thing that got me through the withdrawals. I didn't go to a single therapy session while in the hospital, I simply did it on my own because I have it memorized. Mind over matter is all I can say. Of course I still went through every symptom y'all listed, brain zaps were the worst while awake but waking up soaking wet every morning because of sweating... I'm still on 400mg a day of Effexor IR (venlafaxine), no Pristiq (desvenlafaxine), changed the 1mg of clonazepam twice a day to 2mg of alprazolam twice a day and kept the 2mg of clonazepam at bedtime, added lamotrigine in the morning (gradually working up to 200mg a day), quetiapine fumarate 150-300mg at bedtime to help me sleep, and added amitriptyline 100mg at bedtime. I still sweat when I'm sleeping but nothing at all like way I was during my hospital stay, if I don't take the Xanax I sweat till I'm soaking wet and twitch, shake, get hot/cold, zapped, etc. I've learned that the Seroquel and Elavil I take at night gives me nightmares. However, all in all, I'm doing a whole lot better.

The only reason I was taking so much Effexor IR and even had to add Pristiq was because I decided to make a change in my life by getting off Adderall 60mg a day and IV Meth 3-4gm a month. SNDRI's exist outside of illegal drugs, but I don't think most people would have the desire nor the will power to use them. I did it for me and my daughter, I'll be off of Effexor IR by February. The rest I'm not sure yet, but I'm really scared right now because since I changed the Effexor IR dosage, quit the Pristiq, swapped Klonopin during the day for Xanax, started back on Lamictal in the mornings, and added Elavil at night, my feet, ankles, and legs up to my calves have swollen up so much I can stick my finger into the skin and it cover my entire pinky nail, I can't stand more than ten minutes or my kidneys begin to hurt and in 3mos I gained 60lbs. I'm always out of breath it seems, so I'm going to the doctor in the morning. I don't know what's caused these symptoms, but I have a list of things that probably is.

~When things seem hectic in life just remember to control what you do, don't let what you do control you~

 


God I'm glad all that's over. I've simplified my medication cocktail: 100mg Sinequan/doxepin, 100mg Lamictal/lamotrigine, 30mg Adderall XR 2x day, and I get 60 xanax and 30 klonopin a month, I fill them about every 6 weeks or so. My dad carries his 12ga with him everywhere he goes now, since my uncle's house was broken into while he and Natasha were home and uncle Jerry was shot in the arm while pushing Natasha out of the way. He's lost most of the use of his left arm and my dad partially blames himself because our house is less than two blocks away from Jerry's and you can see clearly from one to the other, however he didn't "already have his gun in his hands." I told him that doesn't make much sense, yet he insisted on carrying the gun from then on, my dad's an Alabamian redneck racist, he didn't decide to keep the ammo in his pocket until he was handcuffed and put in the back of a cop car for tailing a black man leaving the neighborhood. Luckily for him it was a downtown cop up here cheating on his wife. I decided to come back to Bluelight after my long and dreaded hiatus.

I'm not sure if anyone will check a post made on such an old thread, but I just had to share the craziness of life's drama and the relief of poignant delight in changing my meds twice over since last year.


FYI, here in Jefferson County the rednecks are sane, in Walker County sanity is missing and the rednecks are strung out on some form of hard drug, making it, and usually getting killed or arrested while high on it. AVOID WALKER COUNTY ;)



 
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