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Intranasal dmt: maoi needed?

Hmmmm, I imagine that would freak a few people out at an ayahuasca ceremony :) I'd like to see the face of the person handed the cup after you.
 
Snorting that stuff hurts, I just recommend you smoke it. To answer your question, no, the MAO only exists in the digestive tract and snorting is a different pathway.
 
If it's DMT freebase - do not snort it! Convert it to fumarate first.

No MAOi is needed for intranasal or intrarectal as you bypass stomack and liver.
 
Yeah there is loremipsum.. You need DMT freebase, fumaric acid and acetone. If you want it to be snortable, there is a bit of calculation unless you use the exact same ammounts as mentioned in the DMT handbook: http://catbull.com/alamut/Bibliothek/DMT_Handbook.pdf

I made 5-MeO-DMT citrate(water! solution) from freebase, for intrarectal administration. Citrate wouldn't be preferable for intranasal as it is complicated to crystallize - the fumaratesalt aren't and therefore better suited for intranasal administration.

I definately would NOT plugg(intrarectal) DMT freebase - but converting it to citrate(solution) would be okay for plugging I assume, as it was okay with 5-MeO-DMT. You would wan't to use a little to much acid instead of to little - better a small amount of citric acid in the rectum than a little unreacted freebase.

Freebase should hurt a lot both intranasal and intrarectal. 5-MeO-DMT freebase hurts quite a lot to snort!
 
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Are there no absorption issues with DMT freebase taken intranasally? If the pain is not an issue does it work?

Due to finding it difficult to breakthrough as the come up from smoked DMT makes me rather anxious, and my current lack of any MAOI and no immediate intention to search for one I'd like to give snorting it a shot if I can, but I have the freebase and seem to remember thinking I heard someone saying the freebase was inactive when snorted.
 
Snorting DMT gives you vicious alkali burns in the nostril - and two lovely red burns under whichever nostril you snort up.

I could never get it work - by the time it starts working (barely) it's already being deactivated. I think you do need an MAOI to feel much of an effect. You might sort of feel something, like you do if you take it sub-luingal but you don't get anything remotely approaching a DMT trip.

No MAOi is needed for intranasal or intrarectal as you bypass stomack and liver.

I don't think you bypass the liver when taking it rectally. And there are inhibitors throughout the body anyway.
 
Dude if you're having trouble breaking through its probably because your vaporizing method. It can be tricky and you may be ending up wasting a lot of DMT that you believe you're inhaling. What you need to do is the method explained at 3:58 in this video- http://www.youtube.com/watch?v=QtckVptu4I4 - I've used nothing but this method since the first time and never have I not felt the full effects of the weighed dose. You need to let it vape for as long as possible before the first inhale. It will stay within the bottle until you're ready for the first hit. Snorting is supposed to be a pretty cool trip but the burn of the chemical reaction is too strong to enjoy anything thats happening.
 
Ismene said:
"No MAOi is needed for intranasal or intrarectal as you bypass stomack and liver."
I don't think you bypass the liver when taking it rectally. And there are inhibitors throughout the body anyway.
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My bad.. Of course the liver isn't bypassed. Eventually the DMT will go through the liver, but intranasal and intrarectal bypass first-pass-metabolism allowing it into the bloodstream - DMT is actively transported through the BBB from the blood.

Yes MAO is everywhere in the body, but not in high concentrations like in the stomach and liver for instance (irrc)
 
The freebase isn't very water soluble, so that should cause absorption issues in the nose's mucous membranes, right? Acidifying your DMT would fix that I believe.

I think the case is similar for a lot of freebase substances
 
Ismene said:
Sort of. You'll notice a vague sensation. But it won't be anything you could call a DMT trip.
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I've heard of people having very strong trips somewhere between oral and smoked DMT with snorting it without the addition of an MAOI. One thing I did notice is the doses were rather high though, like 125-150mg+

Not sure if it'd be worth all that sting, especially if you do have access to an MAOI as I imagine you could take a LOT less then and extend the trip significantly :)
 
150mg+ is definately going to take every last bit of membrane off your entire nasal cavity and leave you with two vicious alkaline burn marks under each nostril tho JG. I didn't take anywhere near that and was in agony for a fortnight.

That was with DMT freebase tho - perhaps a salt gives you better mileage.
 
^ True. I was going to use lidocaine beforehand to avoid the pain but I've both ran out of lidocaine and it sounds like the pain lasts a little longer...

I do remember snorting just like 5mg as a tester once seemed to produce an extreme burn worse than the burn from 2C-Xs just the drip was a little easier. 8(
 
It's no joke walking round for a fortnight with two long red burns under each nostril.
 
Plugging with vinegar works but it shoots you to the peak within about a minute. You need to get the dose right (ie low enough) otherwise it's about as much fun as being in a car crash.
 
The sitter would need to be a very close friend - you'll feel an overwhelming urge to pull your trousers down and attempt to shit.
 
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