Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

[allthegoodjwh's]

im interested because im prescribed it off topic for anxiety and it has the traditional cns depressant effects, but a paradoxal stimulant effect not resembling a weak mdma-ish(esk) effect
and i couldve sworn that i read that gaba could agonize the ghb receptor and that would make perfect sence, as lyrica increases gaba in the brain which would in turn cause indirect ghb agonization, explaning the stimulation
but if thats not the case its a damn mystery im going to open a add thread to get to the bottom of this, because ive been wordering about it ever since i got it prescribed some many months ago

 

[THCified]

Started with 100mgs 1st day, strange come-up -never thought there even is one with Lyrica but it was there (and reminded me a bit of taking low-dosed Dextrometorphan-, but not much effects at all after the initial bodyload.

Two days later i took 200mgs in the evening, i think i was a lil' bit more sleepy and calm, but that was it.

Well then, today i thought "fuck it" and took 300mgs in the morning. Both times i had no bodyload like the 1st time i took it, but with 300mgs i had a somewhat strange headspace - i was mostly stimulated and noticeable clumsy, but i felt no euphoria or mood-lift at all, just a very weak feeling of well-being/calmness.

So, that's Lyrica?

 

[THCified]

Well, a few days ago i tried 400mgs which were almost exactly as disappointing as the 300mgs i mentioned in the previous post. I of course felt something psychoactive going on, but it was just not pleasurable.

Any recommendations? Should i try taking lower doses for some prolonged time or do i have to take more?

 

[AlphaMethylPhenyl]

Try what you want. For some people Pregabalin is highly recreational and for others they can hardly tell the difference beyond relief of physical discomfort.

 

[Madmike]

Good news:
I have managed to get off Lyrica finally I took it almost everyday from spring 2009. Doses ranging 600 mg / day to 1200 mg / day. Addiction had been quite strong to it.
This summer I made a decision and I reduced 75 mg every third day, from 600 mg to 0 mg. There was not much pain. Slightly increased fatigue and some depression, but it was manageable with exercise and meditation and healthy habits (food etc.). I am currently drug free I have been off Lyrica for a little over month and I feel very healthy.

 

[Jrhguitarist1]

I've took lyrica for two years and I don't understand people gettin high from them. This is one med that I have took a lot of even more that 900 ml but never have got a feeling of being high just kinda get wobbly and can't think straight that I hope isn't someone idea of high. You could just spin to fast on a Mary go round and jump offi and get that feeling for free.

 

[AlphaMethylPhenyl]

I've took lyrica for two years and I don't understand people gettin high from them. This is one med that I have took a lot of even more that 900 ml but never have got a feeling of being high just kinda get wobbly and can't think straight that I hope isn't someone idea of high. You could just spin to fast on a Mary go round and jump offi and get that feeling for free.

Case in point.

 

[spephspeph]

I started taking this a couple of days ago, for nerve damage in my leg causing weird sensations. I was on gabapentin before (for a couple of weeks), but this didn't really do anything except make me dizzy, tired and gave me vivid (sometimes sexual) nightmares.

Seems to be doing the job (impressed that it worked so quickly...!).

Is this ok when combined with MDMA?
Doctor said it might make alcohol a bit stronger, but I didn't ask about anything else

 

[syntheticbreakfast]

You realize that site is basically a front for supplements companies? I'd take whatever they say with a grain of salt, because they obviously have a big vested interest in pushing their 'natural' agenda.

You're missing the point. The findings come from a study done at Stanford University, not people trying to sell supplements. The study has nothing to do with supplements.

Abstract:

Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that induce their formation are not well understood. We have previously identified thrombospondin as an astrocyte-secreted protein that promotes central nervous system (CNS) synaptogenesis. Here, we identify the neuronal thrombospondin receptor involved in CNS synapse formation as α2δ-1, the receptor for the anti-epileptic and analgesic drug gabapentin. We show that the VWF-A domain of α2δ-1 interacts with the epidermal growth factor-like repeats common to all thrombospondins. α2δ-1 overexpression increases synaptogenesis in vitro and in vivo and is required postsynaptically for thrombospondin- and astrocyte-induced synapse formation in vitro. Gabapentin antagonizes thrombospondin binding to α2δ-1 and powerfully inhibits excitatory synapse formation in vitro and in vivo. These findings identify α2δ-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation.

I think people should pay attention to this. It may not be of much concern to people only using the drug occasionally, but daily users might be in trouble if having the drug constantly in their system is reducing the CNS's ability to form new synapses. This could explain why many long-term daily users report a mind-numbing effect and memory issues.

 

[THCified]

Well, took this one again after a while now a few days ago, 100mg in the morning on an empty stomach, and it was really nice! I was very introspective, chatty and sociable while also more open and calm.

It was probably because i was too much into opiates/opioids as i tried it the 1st few times and didn't really felt the effects at all...seemed like they're muted down to almost nothing.

Bad thing, i don't get much salvation off my nerve pain/paresthesia, at least not that much as with opiates/opioids.

 

[lurching]

I get moodlifting effects from Lyrica as well. I asked my doc for it when I kicked a heavy alcohol habit. I started at 3x 75mg per day and it helped wonders for my mood and allowed me to take less benzos for the withdrawal. Two months later now and I'm taking 3x 225mg, sometimes more (up to 800 or 900mg total in a day). Most of the euphoria is gone now, although it is still anxiolytic.

I'm thinking of taking a tolerance break. Right now I need 600mg for a nice effect (two months ago I needed 200mg and have used it daily since). How long of a break should I take to go down to about 300mg per dose?

 

[Non Nobis Solum]

Lyrica is practically the same thing as Neurotin just a different strength per mg dose and a different stereo-isomer of gabatein. It acts uppon your GABA receptors igniting them, it's a very nice combination with Amphetamines, D-AMP, D/L-AMP, D-METHAMP,D/L-METHAMP.. It is practically harmless, the amphetamines unfortunately aren't harmless.. I am sure you know... But any benzo or GABA activating drug is almost a common thing to be RX'ed with amphetamines..

 

[benzoheadplus44]

(erase your inbox so i can respond to u ^^)

but yeah lyrica is nice with amphetamines, i was rxed 2000mg gabapentin way long ago on my old adderall when i was like 19... lyrica feels better and you need less...

theyre coming out with a new analogue of pregabalin i read on wikipedia... pfizer is supposedly for insomnia for when they lose the patent... if this is true or not, idk but that would be badass.... i want to switch from my valium to make it as needed, and use lyrica if my dr would let me, but he says its not as good as diazepam, no shit, but i don't want to be on diazepam daily... lol... i do, but thats not good for dependency issues...

600mg pregabalin is what i used for mood lfting effects, empty stomach with carbonated beverage...

 

[Mercc96]

Atagabalin is what you are thinking of I think, theres also 4 methyl pregabalin or something along those lines.

 

[benzoheadplus44]

Atagabalin is what you are thinking of I think, theres also 4 methyl pregabalin or something along those lines.

yes...

i was thinking of both too.. there will be a ton of these someday...

pfizers drugs neurontin and lyrica are (or were in neurontins case, tho its still common), name brand or generic for neurontin, two of the most common rx drugs... especially with all the off label uses...

id love to get lyrica prescribed... 450-600mg twice a day.. then i can knock off the sonata, and keep my newly raised dosage valium to as needed... he just raised the dose tonight to 20mg twice a day... i cant be dooooinn that lol... because i can make 40mg a day last all month and id be fucked on dependency


not to say lyrica and the like isn't a cause of physical dependency but its not as risky...

kinda went off there on a little thing........

 

[FPU4eva]

(erase your inbox so i can respond to u ^^)


theyre coming out with a new analogue of pregabalin i read on wikipedia... pfizer is supposedly for insomnia for when they lose the patent... if this is true or not, idk but that would be badass.... i want to switch from my valium to make it as needed, and use lyrica if my dr would let me, but he says its not as good as diazepam, no shit, but i don't want to be on diazepam daily... lol... i do, but thats not good for dependency issues...

getting 100 grams of that atagablin i am quite excited to see it doses are around 150mg in trials. I suggested the 4 methyl pregablin first but heard the isomer is hard to isolate and atagablin was easier to make its going to be an exciting compound

 

[stratofortress]

Hi there,

Apologies if this question has been asked before; you know how it is, tens of pages are a struggle to read through, especially after a nice dose of Lyrica.

I'm currently prescribed 400 mg a day, to be taken db; previously I was on 300mg db, which i would take all at once in the morning, and feel freaking great - total peace of mind, motivation, finding things pleasurable...well you know the effects, i need not go on.

Went to collect my meds this morning, and after a short browse of this thread decided to take 600 mg - 450 oral, 150 plugged (noticed no difference plugging...i think oral, on an empty stomach, is the way to go). I've also had one can of 9% lager - 4.5 units, and am feeling pretty darn good....like a benzo high mixed with a bit of opiate noddiness. A bit of verbal (and written) diorrhea as well - anyone else notice they can't shut up when taking these things?

Anyhow, the real question I wanted to ask was with regards to smoking (tobacco) with pregabalin. I searched PubMed, and could only find a report stating that pregabalin was useful in smoking cessation. I'm currently a benzo addict on a taper (which is hell at times), and know that tobacco decreases the blood concentration of many benzos, especially alprazolam. Have any smokers who take 'recreational' doses of pregabalin noticed any effect on it's potency? At a guess I'd say it had little effect, due to pregabalin's very bizarre mechanism of action. I just smoked a pipe (pipe smoker here), and the first few puffs were pure euphoria.

Any more knowledgable bluelighters have information regarding tobacco and pregabalin?

Thanks, Tom

 

[Coraline]

Hi there,

Apologies if this question has been asked before; you know how it is, tens of pages are a struggle to read through, especially after a nice dose of Lyrica.

I'm currently prescribed 400 mg a day, to be taken db; previously I was on 300mg db, which i would take all at once in the morning, and feel freaking great - total peace of mind, motivation, finding things pleasurable...well you know the effects, i need not go on.

Went to collect my meds this morning, and after a short browse of this thread decided to take 600 mg - 450 oral, 150 plugged (noticed no difference plugging...i think oral, on an empty stomach, is the way to go). I've also had one can of 9% lager - 4.5 units, and am feeling pretty darn good....like a benzo high mixed with a bit of opiate noddiness. A bit of verbal (and written) diorrhea as well - anyone else notice they can't shut up when taking these things?

Anyhow, the real question I wanted to ask was with regards to smoking (tobacco) with pregabalin. I searched PubMed, and could only find a report stating that pregabalin was useful in smoking cessation. I'm currently a benzo addict on a taper (which is hell at times), and know that tobacco decreases the blood concentration of many benzos, especially alprazolam. Have any smokers who take 'recreational' doses of pregabalin noticed any effect on it's potency? At a guess I'd say it had little effect, due to pregabalin's very bizarre mechanism of action. I just smoked a pipe (pipe smoker here), and the first few puffs were pure euphoria.

Any more knowledgable bluelighters have information regarding tobacco and pregabalin?

Thanks, Tom

I took gabapentin for a day I had a reaction to it but when I was on out it made me care less about smoking. I had no urges to smoke. This may not really answer your question but it does seem to mess with the pleasure centers of the brain or nicotine receptors in dome way.

 

[Ninae]

Started with 100mgs 1st day, strange come-up -never thought there even is one with Lyrica but it was there (and reminded me a bit of taking low-dosed Dextrometorphan-, but not much effects at all after the initial bodyload.

Two days later i took 200mgs in the evening, i think i was a lil' bit more sleepy and calm, but that was it.

Well then, today i thought "fuck it" and took 300mgs in the morning. Both times i had no bodyload like the 1st time i took it, but with 300mgs i had a somewhat strange headspace - i was mostly stimulated and noticeable clumsy, but i felt no euphoria or mood-lift at all, just a very weak feeling of well-being/calmness.

So, that's Lyrica?

Really, I started out with 600 mgs, but preferred using 1500 when I was using it (or 3000). The dosage makes all the difference. Also tolerance and stomach content, and it doesn't work two consecutive days. 300 mgs is a good anti-depressant.

 

[THCified]

Tell me more about this dosage thing? What's the difference between, let's say 1500 and 300? But 3000 (!), isn't that a bit crazy? How does that feel?