25i-NBOMe and beta blocker

[Ronald Reagan]

I've recently been prescribed 50mg daily of Atenolol to reduce blood pressure and wanted to know what interactions, if any, would exist between this beta blocker and 25i-NBOMe. If this is dangerous, how long after a final dose of Atenolol would it be safe to take 25i? I'm aware that it's not safe to combine beta blockers with amphetamines nor with other potent adrenergic drugs, but am not sure of phenethylamines, this one in particular.

 

[Cyanoide]

Yes, it is potentially dangerous. Do not take a beta blocker with Phenethylamines! Some of the Phens are actually psychedelic amphetamines.

It's only safe to take beta blockers with tryptamines (except for AMT and 5-MeO-AMT). I've done it especially with 4-HO-MiPT and 4-HO-MET as they raise my blood pressure to an annoying point some times.

I've not used atenolol myself, only propranolol and bisoprolol. But I did some googling for you and atenolol has a half-life of 6-7 hours, however the actual effects last up to 24 hours. So I'd say you should wait at least 24 hours before taking 25I-NBOMe.

Do you use atenolol daily? If so there's another problem. Discontinuing the use of beta blockers if used for a prolonged time should be done by taper, otherwise you can get very uncomfortable heart palpitations. You can't just stop 50 mg atenolol cold turkey if you've used it for a long time.

Also remeber that 25I-NBOMe raises you blood pressure, if you have BP issues I strongly urge you to find a psychedelic that doesn't affect blood pressure as much. Those can be found mostly in the Tryptamine class (you can anyway take atenolol with them).

 

[stimutant]

what possible effects could it have to mix bb´s and phen´s?

 

[Cyanoide]

what possible effects could it have to mix bb´s and phen´s?

It can lead to an "unopposed beta blockade". Only beta receptors are blocked but alpha receptors are not. This can lead to a dangerous increase in heart rate and/or blood pressure. Especially with psychedelic amphetamines this is a big problem, as they act on both alpha and beta receptors. If you take a beta blocker on top of this, it can cause a dangerous imbalance as alpha receptors are left unblocked.

 

[Unelmaporsas]

Uh, good info - this should be made more widely known, as beta blockers are quite commonly used (especially among stim freaks). Btw, Cyanoide: you need to clean up your inbox!

 

[Kapitan]

Uh, good info - this should be made more widely known, as beta blockers are quite commonly used

Yeah, absolutely. I had no idea that this was the case. I've taken atenolol with psilocin, and it was great, so I had been considering trying it with 2C-B or DOC sometime soon. Damn.

 

[zn13bt]

Yes, it is potentially dangerous. Do not take a beta blocker with Phenethylamines! Some of the Phens are actually psychedelic amphetamines.

Is it all phens that are dangerous to mix with beta blockers, or just the ones that are monoamine releasers? (The DOx series are structurally amphetamines but I don't believe they cause monoamine release like amphetamine or MDxx does.)

It's only safe to take beta blockers with tryptamines (except for AMT and 5-MeO-AMT). I've done it especially with 4-HO-MiPT and 4-HO-MET as they raise my blood pressure to an annoying point some times.

AMT and 5-MeO-AMT (and presumably (5-MeO-)AET as well) are unsafe because they're also monoamine releasers, is that right?

 

[slo mo]

Yes, it is potentially dangerous. Do not take a beta blocker with Phenethylamines! Some of the Phens are actually psychedelic amphetamines.

It's only safe to take beta blockers with tryptamines (except for AMT and 5-MeO-AMT). I've done it especially with 4-HO-MiPT and 4-HO-MET as they raise my blood pressure to an annoying point some times.

I've not used atenolol myself, only propranolol and bisoprolol. But I did some googling for you and atenolol has a half-life of 6-7 hours, however the actual effects last up to 24 hours. So I'd say you should wait at least 24 hours before taking 25I-NBOMe.

Do you use atenolol daily? If so there's another problem. Discontinuing the use of beta blockers if used for a prolonged time should be done by taper, otherwise you can get very uncomfortable heart palpitations. You can't just stop 50 mg atenolol cold turkey if you've used it for a long time.

Also remeber that 25I-NBOMe raises you blood pressure, if you have BP issues I strongly urge you to find a psychedelic that doesn't affect blood pressure as much. Those can be found mostly in the Tryptamine class (you can anyway take atenolol with them).

What can we take with phens for lowering BP?

 

[Cyanoide]

What can we take with phens for lowering BP?

Try magnesium + taurine. I took them with MXE to lower my blood pressure and they worked like a charm.

@zn13bt, I'll get back to your post when I have more time, or someone with better insight could also answer your questions. Some of the mods on ADD can probably better explain it than me.

 

[Cyanoide]

Is it all phens that are dangerous to mix with beta blockers, or just the ones that are monoamine releasers? (The DOx series are structurally amphetamines but I don't believe they cause monoamine release like amphetamine or MDxx does.)

AMT and 5-MeO-AMT (and presumably (5-MeO-)AET as well) are unsafe because they're also monoamine releasers, is that right?

Please anyone if you have anything to correct please do so (especially you ADD'ers). Anyway I promised to answer you.

Phens are adrenergic agents (= they release norephinephrine = adrenalin). They have siginificact affinity for both alpha and beta receptors. As I said taking a beta blocker on top of this could cause a dangerous imbalance, as alpha receptors are unblocked. Hence, while the beta receptors are being suppressed the alpha receptors are taking the whole "hit", which could mean a dangerous increase in heart rate and pulse. You would have to take a combined alpha/beta blocker and even then I don't know if it would be safe.

It has nothing to do with MAOI's. MAOI's and phens is extremely dangerous and should be avoided at all costs anyway.

Regarding AET and 5-MeO-AMT, they are very weak MAOI's. However, both are alpha-methylated tryptamines, i.e. homologues of amphetamine. Both can hence, like many PEA's, be regarded as "psychedelic stimulants". While not stimulants in the classic sense, any compound with strong alpha/beta receptor affinity should be avoided in combination with beta blockers.

 

[Mela]

Aye, not beta-blockers with phens - very bad idea. Clonidine (an alpha agonist) could be used, though (and currently is clinically for ADHD alongside stims). Tizanidine is another possibility (another alpha agonist).