Methoxetamine: From drug of abuse to rapid-acting antidepressant[didn't see a thread]

[golden1]

http://www.ncbi.nlm.nih.gov/pubmed/22819129
http://www.medical-hypotheses.com/article/S0306-9877(12)00312-X/abstract

Methoxetamine: From drug of abuse to rapid-acting antidepressant
Received 3 May 2012; accepted 5 July 2012. published online 23 July 2012.

Abstract
Methoxetamine is a dissociative anaesthetic showing pharmacodynamic similarities with its analogue ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine and other arylcyclohexylamine compounds, methoxetamine is thought to be both a noncompetitive NMDA receptor antagonist and a dopamine reuptake inhibitor. Furthermore, it acts as an agonist at dopamine D2, serotonin 5HT2, muscarinic cholinergic, sigma-1, opioid mu and k receptors. The hypothesis is that methoxetamine can produce rapid antidepressant effects in patients with resistant and non-resistant unipolar and bipolar depression.

PII: S0306-9877(12)00312-X

doi:10.1016/j.mehy.2012.07.002

© 2012 Elsevier Ltd. All rights reserved.

Anyway it seemed like this fit in ADD and maybe someone here can share the full paper with me or outline it?
Its seems very interesting and useful to know further more specific details or is it just me?

One example being the 5ht2 agonism, would be interesting if they had anything more specific on that(2a? it feels like it sometimes). The kappa opioid agonism is also very interesting

Anyway if its been discussed feel feel to close this.


MXE Pharmacology according to abstract:

noncompetitive NMDA receptor antagonist
dopamine reuptake inhibitor

an agonist at:
dopamine D2
serotonin 5HT2
muscarinic cholinergic
sigma-1
opioid mu and k receptors

 

[THCified]

Interesting! I hope they do more research on this compound.

 

[endotropic]

Wow what a misleading article. As far as I can tell the article itself has no evidence of any of the pharmacodynamic properties listed. Here's the biggest blurb directly discussing MXE in the article:

This substance, used by people for its dissociative
effects, shows pharmacodynamic similarities with its
analogue ketamine [33]. Unlike ketamine, the 2-chloro group on
the phenyl ring has been replaced by a 3-methoxy group and the
N-methyl group on the amine has been replaced by an N-ethyl
group. The change from N-methyl to N-ethyl gives methoxetamine
more potency and duration of action than ketamine while the
change from 2-chloro to 3-methoxy gives methoxetamine less
analgesic and anaesthetic properties than ketamine [34,35].

Here are the references they cite:

[33] Ward J, Rhyee S, Plansky J, Boyer E. Methoxetamine: a novel ketamine analog
and growing health-care concern. Clin Toxicol (Phila) 2011;49:874–5.
[34] Drugs-forum. Methoxetamine. 2011. Available on: http://www.drugsforum.
com/forum/showwiki.php? Title=Methoxetamine (visited April 12,
2012).
[35] Hamilton Morris. Interview with a ketamine chemist. 2011. Available on:
http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2
(visited April 12, 2012).

The first one I can't access and the other two are from drugs-forum and vice. As far as I can tell this paper is saying it would be great if this drug activates these receptors and will be a great antidepressant, but we have no evidence to support this claim. Maybe someone can access reference 33 and find the actual pharmacological data, but I think they're just reasoning by analogy to ketamine.

 

[golden1]

Lol, disappointing.

 

[Epsilon Alpha]

This sounds like it was written by an undergrad...
Drugs-forum.com... Seriously that's like someone quoting me as a reference

 

[amanitadine]

Meh. . . I'm skeptical of some of the pharmacodynamics they list, and seeing who the refs are it makes perfect sense..

 

[endotropic]

Meh. . . I'm skeptical of some of the pharmacodynamics they list, and seeing who the refs are it makes perfect sense..

The apparent creator of a bunch of these arylcyclohexylamines mentions those properties in the vice article, but he seems to be pulling them out of a hat as well.

This sounds like it was written by an undergrad...
Drugs-forum.com... Seriously that's like someone quoting me as a reference

This isn't the first time I've seen a drugs forum cited in a research journal, I'm sure you're a reference somewhere EA :D

 

[Epsilon Alpha]

Haha well you might find some papers I was commissioned to write on epigenomics somewhere
Protip: don't miss a payment unless you want your paper posted as a OP on bluelight Sam

 

[phactor]

At the very least this is a good reminder for people to always check your sources citations.

People have a tendency to find and believe information which confirms their own bias. This is often done unknowingly.