• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Nootropics of the future

atara said:
Peptides from pig brains that cross the blood-brain barrier sounds like a really easy way to get CJD.
Click to expand...
Not really. Prions cause CJD. These proteins, though less complex than viruses, have sufficient complexity to hijack cells' machinery and continuously self-replicate, eventually causing death of the organism. The peptide in semax contains a synthetic version of tuftsin, which occurs in naturally in humans. The synthetic version chains together seven different amino acids, all which occur in humans, although the permutation remains foreign.

Granted, one can still feel worried when contemplating these new compounds. However, I think it best if we worry for the right reasons. We lack long term studies on what this compound can do. The pharmacokinetics don't worry me since the metabolites all occur endogenously. The pharmacokinetics, I keep my eyes open about. We already know that it promotes metabolism of serotonin, and upregulates certain enzymes. I would look out for it upregulating/downregulating other neuroreceptors and/or liver enzymes.

Besides, anecdotal evidence suggests that it functions more as a mood stabilizer and anxiolytic than a cognitive enhancer.
 
monad said:
Not really. Prions cause CJD. These proteins, though less complex than viruses, have sufficient complexity to hijack cells' machinery and continuously self-replicate, eventually causing death of the organism.
Click to expand...

I was under the impression that prions are proteins that promote a different, nonfunctional, and pathogenic fold of other individual protein molecules. They don't hijack cells' machinery in the sense of a virus.

There's a justified concern of (structural) purity of such tissue derived products.
 
Last edited:
sn23 said:
There's a justified concern of (structural) purity of such tissue derived products.
Click to expand...

It sounds like this isn't a tissue derived product, but a synthetic peptide first identified in pig tissue.

monad said:
The peptide in semax contains a synthetic version of tuftsin, which occurs in naturally in humans. The synthetic version chains together seven different amino acids, all which occur in humans, although the permutation remains foreign.
Click to expand...
 
Maybe nobiletin.
AMPA-receptor potentiator, ERK-activator, antidepressant, impressive "slim-maker" in animal models, prescription-free.
 
Sorry for being a little bit off-topic. I see you are discussing Cerebrolyzine, I live in Russia, and here it is very easy to obtain, and here comes the interesting part - I have read a story from ony physician that in the 80s it was very hard to obtain it, because junkies were beying it and added it to the solution of drugs he didn't mention, because of it's ability to do something with BBB, unfortunately he didn't metioned what kind of druggiies it was, but from what I gather in 80's there were 3 possibilities:
-acetylated opium(known as "kompot" or "hanka")
-crude RP/I meth from ephedrine(no extraction, just acidic yellow solution that was neutralized by adding baking soda)
-Methcathinone from ephedrine(via KMNO4 route).
My guts are telleing me that it was acetylated opium, i think peptides will broke down in the pervitin solution.
It is still used in Russia, it's given after stroke and it helps with recovery.
You can read the story here http://www.reliefracer.com/akademiya_rodnaya/1733_tserebrolizin_na_karmannye/
 
What's the strongest Nootropic available? Already tried Piracetam

Thanks
 
Dunno said:
What's the strongest Nootropic available? Already tried Piracetam

Thanks
Click to expand...
Supposedly phenylpiracetam is pretty potent, although noopept is much easier to get. Noopept is the typical "strong" nootropic.
 
Keep in mind, that with noopept, it could easily take up to ~14 days until you start to notice any positive benefits from it, as it's effects are more cumulative.
I certainly feel strong effects within minutes of ingestion, on the first day of a noopept cycle; but this doesn't seem to happen to everyone.

Someone correct me if I'm wrong on this.
 
Which nootropic(s) have the least potential of aggravating bipolar or schizophrenia? Are any additionally useful antidepressants and/or anxiolytics?
 
DexterMeth,
can you, please, describe the subjective feelings and overall expierence more precise?
 
Last edited:
Dunno said:
Thanks. What is a good daily dose of Noopept?
Click to expand...

I find racetams effective in lower doses. For noopept, I prefer 5 mg twice a day, although sometimes, 10 mg twice daily. Clinical trials testing its efficacy used 10 mg thrice daily. Humans can generally tolerate doses in the hundreds of miligrams without damage. Try 10 mg thrice daily and decrease of increase from there. Your milage may vary. Keep in mind that many users have reported irritability after persistent dosing, so an incentive exists to find the lowest effective dose.
 
This is getting dangerously close to imminst level discussion. More abstracts and primary literature please
 
You must log in or register to reply here.
Top