How to mitigate trippiness of 6-APB (and/or MDA)

[Sapphires]

I'm looking for any and all methods to mitigate/eliminate any hallucinations/distortions/altered headspace caused by 6-APB while still allowing speedy/euphoric/empathogenic effects. Since 6-APB is an MDA analogue and acts very similarly, advice to achieve this goal for either drug would probably work.

I know that 6-APB is not fully researched as far as pharmacological action, but the general consensus is that it's a re-uptake inhibitor of serotonin, dopamine, and norepinephrine and acts on the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It seems the easiest way to stop the trippy effects (akin to MDA) but keep the speedy entactogenic effects (akin to MDMA) something needs to prohibit it acting upon the 5-HT2C and 5-HT2A receptor.

Similar to how an SSRI 'takes the place' of where MDMA wishes to bind to, therefore dampening a roll heavily, I am looking for a drug that would 'take the place' of the 5-HT2C and 5-HT2A receptors or work as a complete or partial antagonist upon them. I've found many antidepressants/antipsychotics that work on various receptors and even the two I want, but many simultaneously act upon systems which I want to be left alone for the desired speedy/euphoric/empathogenic effects.

What I'd like to know is if this method would even work or what specific drugs (antidepressants or antipsychotics) specifically target the receptors I've mentioned.


I admit that I am not a chemist and may be heavily butchering how these systems work, also if this thread is better suited in ADD I apologize.

 

[justinsayno]

i think you are just taking the wrong drug...

have you tried MDAI + a stim ?

 

[cannibalsnail]

MDAI + 2-FMA is amazing. Try that.

Best bet OP is to trip the day before. That way you'll have a tolerance to the psychedelic portion.

 

[Jesusgreen]

I don't really get enough psychedelic effects from 6-APB to justify taking something to mitigate those effects even if I hated psychedelic effects, and since you're looking at having to take an anti-psychotic or anti-depressant, I really wouldn't advise it.

Why do you want to avoid these effects? Have you tried 6-APB before, or are you just expected it to be too psychedelic for your liking?

Also, try taking a lower dose if it's too trippy. The difference between 150mg and 250mg for me produced way more psychedelic effects and also more side effects while the increase in euphoria wasn't all that big and 150mg's euphoria is more than enough for me.

 

[any major dude]

Well, you could n-methylate your 6-APB, that seems to work with MDA ;-) Or you could just buy some 5-APB and a stimulant, or you could trip the day before. You don't want to go mixing antipsychotics & unresearched monamine releasers /reuptake inhibitors

 

[Sapphires]

I don't really get enough psychedelic effects from 6-APB to justify taking something to mitigate those effects even if I hated psychedelic effects, and since you're looking at having to take an anti-psychotic or anti-depressant, I really wouldn't advise it.

Why do you want to avoid these effects? Have you tried 6-APB before, or are you just expected it to be too psychedelic for your liking?

Also, try taking a lower dose if it's too trippy. The difference between 150mg and 250mg for me produced way more psychedelic effects and also more side effects while the increase in euphoria wasn't all that big and 150mg's euphoria is more than enough for me.

I tried 6-APB at a dose of 120mg and about 45 minutes after consumption the psychedelic effects (notably distortions) started to become more and more apparent and overwhelming. I do not have a personality that is conducive for any sort of trippiness (I get extremely paranoid which quickly turns into panic) and I decided to kill the experience about 60 minutes in with benzos. I was aware and I'm still aware that the psychedelic aspect of 6-APB is very 'lite' especially at this dosage and only really comprises of distortions and not true hallucinations, but the fear of the distortions growing more and more apparent and possibly falling into a trippier headspace is what scared and scares me.

The distortions were mainly text distorting (trailing to create 3-5 duplications of the text that lasted for a while), visual trailing, walls and objects breathing, and the feeling of being on the edge of a trippy headspace. I understand that 6-APB causes this, but I was under the impression (and realize I may have been wrong) that these effects only become truly apparent at dosages higher than 150mg rarely and higher than 200mg frequently. The fact that you've mentioned the difference between 150mg and 250mg separating the trippy effects is what I was also going by as it seems to be common knowledge, and encountering them at a dosage at 120mg is what bothered me.

The reason I made this thread is that the entactogenic and stimulant sides of the 6-APB were fine and the substance definitely showed potential, however I want to remove or mitigate the trippiness. Considering that the majority of distortions and negative effects I listed are down to the 5ht2a and 5ht2c receptor, a drug that works as an antagonist (partial or full) should stop this while allowing the effects I want. In the time since creating this thread I've found a few different options, one being Cyclobenzaprine (http://en.wikipedia.org/wiki/Cyclobenzaprine) which has known use for destroying the trippiness of drugs like LSD.

Well, you could n-methylate your 6-APB, that seems to work with MDA ;-) Or you could just buy some 5-APB and a stimulant, or you could trip the day before. You don't want to go mixing antipsychotics & unresearched monamine releasers /reuptake inhibitors

Why are mixing antipsychotics and monoamine releasers/reuptake inhibitors dangerous? That's the type of information I'm looking for. What are possible scenarios? Since 6-APB is an analogue of MDA, surely there are reports of users mixing these two drugs and while I understand that an unresearched analogue is still chemically vastly different, it's still a step in the right direction.

i think you are just taking the wrong drug...

have you tried MDAI + a stim ?

MDAI + 2-FMA is amazing. Try that.

I'm well aware that there are better substances to achieve what I'm looking for, I could list a dozen more beyond the ones you both suggested, but that's not what I am interested in. Pharmacologically speaking, it should be possible to narrow down the effects of 6-APB by using 5th antagonists. That's what I wanted to discuss.

 

[skillet]

Just take a lower dose, maybe it affects you more strongly than most people. Antipsychotics will block 5-HT2A, but usually also block other serotonin receptors, dopamine receptors, H1, alpha-adrenergic, mACh... I doubt there'd be much left to enjoy after all that, maybe mostly adrenergic effects.

I haven't found MDA to be trippy at all really, but I haven't taken it much above 100mg.

 

[Survived Abortion]

Anti-psychotics are horrible drugs, I wouldn't even go there. Ketanserin is the only compound that comes to mind which predominantly selectively antagonizes 5-ht2a receptors. But seriously, if you are really going to go to such effort to try and selectively diminish 5-ht2a activity, then why bother at all. It seems like a complete waste of time to me.

Not to mention the fact that 5-ht2a antagonist drugs will exert their own psychological effect, completely altering the nature of the whole experience in a negative way. As others have said, just find another drug such as MDMA. Forget anti-psychotics.

 

[HillsofFoot]

These issues with the chemical you are describing, as side effects, are simply just the trip. If you have ever done enough MDMA at once you know how psychedelic that can feel. Blurry vision, odd clips playing in your head... simply put - it gets weird. You are, after all, on drugs. The only way to take the psychedelia down a notch is to take less substance. Anything else will alter the trip.