Idk why everyone's talking about depleted SR levels, pretty sure your 5-htp fixes that (take a night or two after rolling, up to 200mg at once maby? I'd do 100mg or two nights, first being the night after the day I rolled). You need to worry about SR receptor over stmulation, and maby some DA too, and perhaps transporter over stimulation? Pretty sure both of those lead to down regulation in the end, as less healthy working receptors to recieve leads to less SR emotion. I'm not sure about the transporter over stimulation, just a thought. Look some of that stuff up, hopefully you can find some well done info writen on it. I rarely do ecstasy, but when I do I sometimes end up doing it a few times close together, and doing this rarely + using 5-htp has lead me to no problems. I keep pill numbers low, 1-3 dank pills usually (old legit ones i saved, wouldn't trade most of them for 99.5% of pills in the US now), but since those are about gone, I'll move on to molly next time.