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What is the most addictive substance?

Rabidrabbit said:
Yup -- When you inhale a substance, it goes straight to the brain, bypassing all of your body's 'filtering' mechanisms. Every other ROA has to pass through (oral) gastrointestinal -> bloodstream -> brain or (nasal/IV/rectal) blood stream -> brain. Thank you, Drugs and Behavior class. Easiest A everrrr.
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im guessing you had bluelight to help you with that class, though, am i right? :) i did my final project for high school on addiction, and if it werent for bl, i would not have passed. i wasnt a member at the time, though, just a reader of the forum. with bl's (as well as adderall's) help, it was the easiest A, but not only that, my principal said it was the most informative and thorough essay he's heard in years. My previous project was an essay/presentation about psychedelics, and got a similar reaction from my teachers. Weird that i didn't even get judged or told off or anything for always doing drug topics... i would imagine in any other school, those essays would have not sat well with teachers. i guess it's cause in LA even the teachers are stoned.
 
Bigfanofthemdrugs said:
im guessing you had bluelight to help you with that class, though, am i right? :) i did my final project for high school on addiction, and if it werent for bl, i would not have passed. i wasnt a member at the time, though, just a reader of the forum. with bl's (as well as adderall's) help, it was the easiest A, but not only that, my principal said it was the most informative and thorough essay he's heard in years. My previous project was an essay/presentation about psychedelics, and got a similar reaction from my teachers. Weird that i didn't even get judged or told off or anything for always doing drug topics... i would imagine in any other school, those essays would have not sat well with teachers. i guess it's cause in LA even the teachers are stoned.
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I guess I can give BL some credit, but it was mostly from personal experiences and Erowid and not being an ignorant asshole who believes everything they hear/read... even my professor said "Adolofine" (or methadone) was synthesized by the Germans and named after Adolph Hitler... but I let that one go because he'd been smoking crack for many years, decided to clean up and form a sober living house/AA/NA meetings in a poor section of NYC.

EDIT: We also had to write a paper about "giving up something" for a week to experience "addiction/withdrawal"... and I was like ummm WTF am I gonna write about, Oxycodone, Adderall, Weed... I just made up some BS about giving up coffee for a week and got an A, hahaha
 
Tobacco. It's harder for me to quit smoking than getting off opiates and benzos, although heroin comes very close in terms of addictiveness imo.
 
The top would be heroin, which was the first opiate IV i ever tried and got instantly hooked. but behind that i would say dilaudid
 
Rabidrabbit said:
Yup -- When you inhale a substance, it goes straight to the brain, bypassing all of your body's 'filtering' mechanisms. Every other ROA has to pass through (oral) gastrointestinal -> bloodstream -> brain or (nasal/IV/rectal) blood stream -> brain. Thank you, Drugs and Behavior class. Easiest A everrrr.
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While this may be true, I still believe that I.V produces the strongest 'rush', as though smoking may hit the brain faster, their are few drugs that are small enough, and potent enough, that you'd be able to consume through inhalation a sattissfying ammount which would create as strong of a rush as I.V can (which is concentrated and has a 99-100% BA)... I feel like I worded that poorly, hopefully my point gets across. Basically, if you ask anyone who's smoked and injected heroin, they'll tell you that injecting it creates the more powerful onset.
 
^It isn't true, you inhale into your lungs, not your brain, vaporised drugs still have to go through your bloodstream (your respiratory tract too, that being a "filtering mechanism"). IV is the ROA that most completely bypasses your body's defenses against foreign substances.
 
Vader said:
^It isn't true, you inhale into your lungs, not your brain, vaporised drugs still have to go through your bloodstream (your respiratory tract too, that being a "filtering mechanism"). IV is the ROA that most completely bypasses your body's defenses against foreign substances.
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Damn, more Lies my teacher told me. :( I think he was using cocaine as an example, though. Smoked vs. snorted vs. injected.
 
Most people would say that the most addictive drug I've ever done was either meth or crack, but those didn't do shit for me. I mean, I loved the high, but I didn't go crazy wanting more.

I just wanted my next pill, haha. I still love to do both occasionally, but the absolute most addictive drug I've ever done... a tie between the Oxycontin 80 mgs I used to get a couple of years ago and the stop-sign Opana 40 mgs I got up to 2 months ago. Totally addictive, more than my roxies, and def. more than this much-more-crappy new-school Opana.
 
It doesn't matter what the drug is. Imagine that you inhale a virus; you have cilia, mucus, immune defenses in your lungs, and it's unlikely to make you sick. Inject a virus, though, and it's a whole different ballgame. The virus is in your blood right away. Smokers don't really have to worry about hepatitis and HIV, injectors really do.
 
Vader said:
It doesn't matter what the drug is. Imagine that you inhale a virus; you have cilia, mucus, immune defenses in your lungs, and it's unlikely to make you sick. Inject a virus, though, and it's a whole different ballgame. The virus is in your blood right away. Smokers don't really have to worry about hepatitis and HIV, injectors really do.
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Isn't it just about which ROA crosses the BBB quickest? I'm not arguing; I'm just trying to learn. Of course anything you inject into your bloodstream is going to carry greater risk. Plus; the most ubiquitous virus is the Common Cold, which you usually get by inhaling particles of the virus.
 
I might be wrong, but I don't think the manner in which the drug enters your blood determines the speed with which it crosses the BBB. Once it's in your blood, it's in your blood, and what happens from there is the same regardless. I'm not a pharmodynamicist though, so take this with a pinch of salt. Yeah, you do get the common cold through inspiration, but you contract it relatively rarely. If your blood was open to the air, I think you'd be very sick almost all of the time.
 
I think that I previously I put heroin as my answer on this thread.
But thinking about it again, I would have to say that nicotine is probably the most addictive drug I take.
I've been smoking since around age 15 and I'm now 41 and the few times I have tried to quit I've only managed to go without smoking for a few days.
Heroin I've managed to quit for a few months at a time before.
So for me personally I find nicotine more addictive.
 
effie said:
You got it with your first sentence.. everyone is different and you are likely to get a lot of people arguing for their DOC and getting upset/defensive if others disagree in a thread like this.. It is an interesting topic, however. Addiction is often less about the specific drug IMO/E and more about the addiction as a whole, or self-medicating, or escapism. Some drugs are more likely to cause a physical dependence than others, but it is possible to become psychologically addicted to most (if not all) drugs. Why certain drugs appeal to certain people interests me a great deal; why do some people become opiate addicts where as others become tweakers? Why can't some people stop popping benzos where as others need to put a needle in their vein? With me, it has definitely been more about the addiction (and later on the ROA) than the specific chemical and I used to switch round drugs a lot.

This would be triggering in TDS, and we don't do long discussion threads in BDD (check the guidelines in my sig and the "state of BDD" sticky) so I'm going to try it in DC - but it may not be quite right for there either..

BDD > DC
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very good post all my addiction problems are based on relaxer drugs i will take uppers but i never form a mental addiction to them

just opiates and benzos
 
Vader said:
^It isn't true, you inhale into your lungs, not your brain, vaporised drugs still have to go through your bloodstream (your respiratory tract too, that being a "filtering mechanism"). IV is the ROA that most completely bypasses your body's defenses against foreign substances.
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That doesn't mean it reaches the brain faster. Smoking is still the fastest way for a drug to reach the brain.

This is the answer:

While this may be true, I still believe that I.V produces the strongest 'rush', as though smoking may hit the brain faster, their are few drugs that are small enough, and potent enough, that you'd be able to consume through inhalation a sattissfying ammount which would create as strong of a rush as I.V can (which is concentrated and has a 99-100% BA)... I feel like I worded that poorly, hopefully my point gets across. Basically, if you ask anyone who's smoked and injected heroin, they'll tell you that injecting it creates the more powerful onset.
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Although an intravenous dose can be pushed at a variety of speeds, and sometimes injections are quite slow, the idea is that 100% of the drug is almost simultaneously inserted into the bloodstream, and 100% of it generates effects prior to being metabolized (full bioavailability). The bioavailability of substances when smoked varies quite a bit, but it is never 100%. Thus it is practically impossible to get similar amounts of a given drug into the bloodstream as quickly as via I.V. injection, even though smoking produces initial effects more rapidly.
 
Znegative said:
While this may be true, I still believe that I.V produces the strongest 'rush', as though smoking may hit the brain faster, their are few drugs that are small enough, and potent enough, that you'd be able to consume through inhalation a sattissfying ammount which would create as strong of a rush as I.V can (which is concentrated and has a 99-100% BA)... I feel like I worded that poorly, hopefully my point gets across. Basically, if you ask anyone who's smoked and injected heroin, they'll tell you that injecting it creates the more powerful onset.
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well meth is a little different, i think, as I've smoked and injected both substances and while IV heroin is obviously WAAY more euphoric and addictive than when smoked, smoked meth seems to be more addictive, while less euphoric, than injection. it also hits slightly faster, by about 20 seconds. meth hits you literally as you exhale, while when i shot meth, i expected it to hit me even quicker. i actually stood up and said to my friend "dude, this isn't working, this shit's bunk!" but before i could finish, i was floored haha
oddly enough, there was absolutely zero impulse to redose, and there wasn't much of a crash from that either. the high was like 8 hours too, which confuses me, as IV drugs tend to be short-lived. Smoked meth has like maybe 30-45 minutes of duration, followed by effects that are hardly noticable enough to call a "high" lasting anywhere from 4-24 hours, thus making it fiendy and giving you an intense impulse to redose, similar to crack or snorted cocaine, but way more intense IMO. Then you get in the cycle of smoking meth to fix the crash from smoking meth, which usually lasts until the substance is all gone.
 
Bigfanofthemdrugs said:
well meth is a little different, i think, as I've smoked and injected both substances and while IV heroin is obviously WAAY more euphoric and addictive than when smoked, smoked meth seems to be more addictive, while less euphoric, than injection. it also hits slightly faster, by about 20 seconds. meth hits you literally as you exhale, while when i shot meth, i expected it to hit me even quicker. i actually stood up and said to my friend "dude, this isn't working, this shit's bunk!" but before i could finish, i was floored haha
oddly enough, there was absolutely zero impulse to redose, and there wasn't much of a crash from that either. the high was like 8 hours too, which confuses me, as IV drugs tend to be short-lived. Smoked meth has like maybe 30-45 minutes of duration, followed by effects that are hardly noticable enough to call a "high" lasting anywhere from 4-24 hours, thus making it fiendy and giving you an intense impulse to redose, similar to crack or snorted cocaine, but way more intense IMO. Then you get in the cycle of smoking meth to fix the crash from smoking meth, which usually lasts until the substance is all gone.
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Especially for users without a tolerance, it is much easier to smoke an active dose of meth in one very quick hit than it is to do the same with heroin. The bioavailability of meth when smoked is in the 90% area, I believe, whereas with heroin it's something like 50%.
In terms of the route of the drug from the point of entry to the brain, smoking is always faster than intravenous injection, regardless of what the drug is. It may just take a while for enough of the drug in question to be absorbed through the lungs in sufficient amounts through holding in vapour/smoke or repeated hits, or the effects can be almost instantaneous.

EDIT:
The only drug for which I can compare the two ROAs in terms of the onset of effects is cocaine. Smoked freebase definitely hit me faster than slamming it, although the high from smoking it is pretty subtle and nothing to write home about, especially compared to the sledgehammer hit from injecting it.
IV morphine hit me pretty fucking fast. Smoked DMT, particularly if it's of high purity (and you've lowered the dose needed for full-blown psychedelia by taking MAOIs and perhaps another tryptamine like LSD/mushrooms), can come on as fast as almost any drug. Smoked meth also has a rush which is almost immediate. Smoking a few of these drugs produces effects faster than injection possibly could - the science makes sense.
 
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Psychonauticunt said:
Especially for users without a tolerance, it is much easier to smoke an active dose of meth in one very quick hit than it is to do the same with heroin. The bioavailability of meth when smoked is in the 90% area, I believe, whereas with heroin it's something like 50%.
In terms of the route of the drug from the point of entry to the brain, smoking is always faster than intravenous injection, regardless of what the drug is. It may just take a while for enough of the drug in question to be absorbed through the lungs in sufficient amounts through holding in vapour/smoke or repeated hits, or the effects can be almost instantaneous.

EDIT:
The only drug for which I can compare the two ROAs in terms of the onset of effects is cocaine. Smoked freebase definitely hit me faster than slamming it, although the high from smoking it is pretty subtle and nothing to write home about, especially compared to the sledgehammer hit from injecting it.
IV morphine hit me pretty fucking fast. Smoked DMT, particularly if it's of high purity (and you've lowered the dose needed for full-blown psychedelia by taking MAOIs and perhaps another tryptamine like LSD/mushrooms), can come on as fast as almost any drug. Smoked meth also has a rush which is almost immediate. Smoking a few of these drugs produces effects faster than injection possibly could - the science makes sense.
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why is it that smoking weed hits you in like 10 minutes rather than as quick as other smoked substances? just a thought
 
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Damn.. this is a tough one. I'm going to have to say its a tie between Smoked quality crystal meth, the almost instant euphoria it gives it almost unmatchable. Crack cocaine is right behind Tina.

I would also say that Heroin IV is the 2nd. Mainly because of the fact that I nod the fuck out for X amount of time and don't have the constant urge to redose as I do with smoked Tina.

And Im going to throw in at #3 Benzos/alcohol. <FUCK these droogz
 
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