I come down when it kicks in and come up when it wears off. Does anyone here have a good understanding of the pharmacology involved with amphetamine?
I mean, this isn't exactly a fair pharmacological question. Amphetamines are among the most mechanistically elusive psychoactive substances ever studied. Presently, not even the most well-read, seasoned scientists working in the field of pharmacologic research have a full understanding of amphetamine's MOA, let alone a bunch of laymen (and a small handful of trained chemists/pharmacologists/neurobiologists) on Bluelight. The fact of the matter is that amphetamines tend to consistently elicit a broad set of predictable responses, including but not limited to improvement of executive function, reaction speed, coordination of movement; increased cardiac output, blood pressure, etc.; stereotyped behaviors such as punding, finger-drumming, or foot-tapping; and a few subjective effects, e.g. euphoria and the like. Even the effects listed above appear to be heterogeneous in their occurrence, the distribution of which appears to be unpredictable without the aid of genetic testing or preexisting knowledge of an idiosyncratic reaction due to illness or something; and once you consider all the other ancillary effects that these drugs can induce, what you're left with is anything but explicable.
For instance, some people can ingest large doses of amphetamine and experience only a small degree of subjective 'drug-liking.' Some users, myself included, experience palpitations on doses as low as 5mg, and severe dry mouth at dosages >10mg. Vasoconstriction is similarly variable - some get speed-dick, some do not. The point of all this being, I've ceased to be amazed by reports of bizarre responses to amphetamines that I encounter on the internet, if only because I've read of so many that I'm considering writing The Varieties of the Crystal Experience. That said, your particular variant is most unusual - it's as though you exhibit something akin to an inversion or 'mirror-image' of the drug's typical dose-response profile. I cannot begin to imagine what mechanism underlies the phenomenon, but I feel compelled to tell you that the answer of which you're in search is not likely to be found on these boards or anywhere else...at least for the next few decades. We (i.e., the scientific community) are simply not there yet.
If I were forced to speculate, however, I suppose that some wacky mutation affecting the behavior of the catecholamine transporter(s) or receptor(s) might explain it. Or maybe your drug/neurotransmitter metabolism is fucked up. Do you respond idiosyncratically to any other drugs? If I were you, I would look for a clinic or a hospital currently conducting studies on psychostimulants (or their respective addicts) and inquire as to whether or not you would be an eligible research participant.
