Opioids Why Is My Opioid Tolerance So High? (Nonfrequent User)

[curioushat]

Hi,

I have been trying to figure this out for a few days or so, so I'll just throw it out here.

Let me start off by saying that I am not a heavy opioid user, barely a casual one. I will take opioids perhaps once a month (sometimes less frequent, going many months in between). So I am very doubtful that I have any sort of built up tolerance.

However, when I do elect to take them, it takes a borderline absurd amount for me to feel a high.
The first time that I took any sort of opioid was out of the medicine cabinet back when I was in high school. Don't think I ever really got above 25mg of Oxycodone or 10mg of Dilaudid. Felt almost nothing, so I put them away.
Flash forward to college where I had access to purchase them for the first time. I purchased 4 oxycodone 30mg IR pills. I took 3 of them at a time, then the fourth about two hours later. That's 120mg total. I actually felt quite fantastic. I certainly didn't overdose, no negative side effects and I certainly did not nod. I just had a fantastic buzz going. I repeated this a few times again, usually months in between. Diminishing results, eg I would take 60mg and feel a moderate but not at all heavy buzz, if that. One time I took 150mg in a night, felt a moderate-heavy buzz. However by the third day in a row of doing that, feeling only a mild buzz.
Now, post college I have experimented a few times. An oxy 30 IR does nothing, doing 2 of them does provide a mild buzz. I have done 100mg several times since then (again a month or so in between-minimum). I really don't get a high, I feel somewhat nice but nothing great. Considering the price, paying <a lot of money> for a weaker buzz than a few hits of marijuana, is just not worth it for me. And I've been smoking weed for years now almost daily. I have tried Oxycodone, Hydrocodone, Oxymorphone, Hydromorphone, Codeine, and Tramadol, and the results are less than stellar even at high amounts.

When I read other reports of naive opioid users, it seems that they can get off to a lot, lot less. Like 20mg oxycodone is killer for a first time user. Getting up to 60mg seems to take practice, and 100+mg is only for veterans (although I know it can go much higher) However it took me 120mg for it to be killer first time? And 25mg didn't do jack?

The oxycodone and hydrocodone have all been oral, because it has the highest BA. I've tried snorting oxy IR, with even worse results. Never tried plugging or an IV. I've tried potentiating with grapefruit juice and the like, including those pills I can't seem to remember right now (they were for indigestion-not TUMS). Drinking alcohol adds somewhat, smoking pot is a whole other dimension, but only because I am high-not nodding from the opiates. DXM, diphenhydramine, hasn't done jack really.

I'm small too, only about 60kg/132lbs.

What gives? I wish I could experience joy for less than <a lot of money> a night. It also makes taking the ones with APAP pointless, since even the 10/325mg would require me to take over 4g to get anything decent.

Thanks in advance!

 

[Swimmingdancer]

Oral administration of opioids does not provide a "rush" - are you just using the word "rush" to mean "high"?

Some people just have a very high natural tolerance to opioids. You might have better results with plugging, why not give it a shot?

As for pills that contain APAP, you can do an extraction to remove most of the APAP.

 

[curioushat]

Oral administration of opioids does not provide a "rush" - are you just using the word "rush" to mean "high"?

Some people just have a very high natural tolerance to opioids. You might have better results with plugging, why not give it a shot?

As for pills that contain APAP, you can do an extraction to remove most of the APAP.

I'm sorry, I'll go change the terminology now. I don't mean rush, I mean just general high from opioids. They're just so weak. I know now about the CWE, and why I should do it instead of taking tons of Tylenol. I might try plugging.

 

[tricomb]

You could try plugging but I'd be surprised for you to get something out of that and nothing out of oral use especially with the *codones.

What else could be affecting this? What other drugs do you do? Do you exercise and eat properly?

 

[grimsolem]

I have had a similar experience, op. I think it may have to do with a high endorphin tolerance due to years of heavy exercise. regardless, my natural tolerance wont fall below a certain point - there doesn't seem to be much you can do aside from looking into potentiation.

 

[curioushat]

Always been pretty active (although used to be very active). Healthy in all ways I can think of. Fit with low body fat. Currently, I really do nothing. I might smoke pot 4-5 times a week, drink moderately once a week.
Grim, you mention the high endorphin tolerance, but wouldn't the amounts I am taking make the layperson throw up violently, nod out, possibly end up in the hospital with respiratory depression?
I feel your pain about the amounts necessary. It's sad, and I won't go for paying large amounts for huge amounts of opiates. Makes me feel like a seasoned addict.

I've tried everything I can for potentiation... Hydroxyzine, Diphenhydramine, DXM, alcohol, cannabis, that indigestion pill (not TUMS), Grapefruit juice. In fact all of these at once with 100mg of oxy (oral) and no nod. I've never nodded once in my life and I feel left out.

 

[tricomb]

If you weren't meant to nod, you weren't meant to nod IMO. I'd see this as a blessing not a curse.

 

[Swimmingdancer]

Grim, you mention the high endorphin tolerance, but wouldn't the amounts I am taking make the layperson throw up violently, nod out, possibly end up in the hospital with respiratory depression?

It is much more likely to do with the way your body metabolizes the opioid. Everyone has differences in their metabolism and their liver enzymes. It's not unheard of for a person to have an extremely high natural tolerance to specific opioids or to all opioids.

It's sad, and I won't go for paying large amounts for huge amounts of opiates.
I've never nodded once in my life and I feel left out.

I would not feel sad about not being able to get very high/nod from opioids, I would agree with tricomb and say it is a blessing in disguise - maybe you will be less likely to get addicted to them.

 

[Tripman]

People who chase a nod die.

It sounds to me that opioids are not something you should bother with and TBPH I think this is a blessing in disguise.

 

[sekio]

Some people have an intrinsically higher tolerance to opioids than others - it's just one of life's little miracles.

 

[The Dope Man]

I have the same problem as you OP. I use rarely and have to take 2-3 30mg roxis to get high. IT sucks dick !

So I started buying ridiculously pure heroin and snorting and IV'ing it. Still didnt get as high as I did the first 4-5 times I took hydro or oxy.

But I dont recommend you mess with heroin. Definitely dont IV.

Like everyone else said just take it as a blessing.

 

[Deblanc]

People who chase a nod die.

It sounds to me that opioids are not something you should bother with and TBPH I think this is a blessing in disguise.

^ This. People who chase a nod die. And since you ARE able to get high, that means you are not immune to opiates. With the amounts you are taking, if you chase that nod, you will wake up dead. If I were you I would listen to what the drug is telling you and stay away.

 

[tricomb]

Waking up dead, hard to do!

Serious good advice in this thread, take it.

 

[Transcendence]

I almost posted this exact same thread. When I was 17 and first started using oxy, 20mg made feel okay but nothing mind blowing. Since then I've used oxycodone an average of once every 3 months, (in this past year an average of once a month).

Literally every time I take oxy I need to take significantly more to get high. Last night I took 90mg of roxi along with an antihistamine and just felt slightly euphoric and sleepy. Shouldn't 90mg be a dangerous dose for someone who does opiates once a month max? Then I have a friend who sniffs oxy 4 days a week for the past 5 years and she still gets off on 20-30mg. The fuck?

It's so not worth paying so much to feel nice for 3 hours. Would rather not switch to heroin, so I know I should just stop now.

 

[Psychonauticunt]

Sounds like you have rather high natural tolerance - it's unusual, but not that strange. People respond differently to different drugs.

I wouldn't necessarily take 120mg of oxycodone without calling an ambulance, so your tolerance seems to be higher than mine, which seems to be higher than average. I'm a sporadic user and take long enough between doses to completely reverse any acute opioid tolerance. The first time I took oxycodone I took 40mg on top of about a third of litre of vodka (which was a stupid idea), and felt mildly unpleasant for a few minutes - possible even just from vodka - and pretty awesome for the rest of it.
The first time I tried injecting anything I shot 40mg of morphine, and that seemed a completely reasonable dose (although undeniably awesome), without any significant discomfort from unwanted side effects.

It's probably a good thing - a higher tolerance makes it less likely you'll overdose accidentally, as long as you keep your wits about you with opioids. Also, DICK MEASURING CONTEST!