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  • BDD Moderators: Keif’ Richards | negrogesic

Vyvanse not working

Shady Kaity

Shady Kaity

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Joined
Jun 3, 2009
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dirty jersey
I went on a three day dxm binge and yesterday I was dead exhausted. So today I thought I'd take double my dose of 70mgs of vyvanse to pick me up a little, but I feel like nothing. I've had this happen before, why am I exhausted the day after dxm and why does nothing help pick me up?

It's not just the vyvanse, before I was rxed it I would take adderall or Ritalin the day after dxm and still nothing. Same goes for any energy supplements, caffeine, ect.
 
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Your liver probably isn't metabolizing the substances. Also, from what I remember DXM fucks with serotonin and dopamine and if your production has gone haywire you probably aren't going to feel an amphetamine or opiate high.

I'd leave that goddamn DXM alone and find a nice friendly local dealer of highly illegal but much effective and pleasurable substances.
 
I'm pretty sure Vyvanse is actually set up to not be effective in high doses, because they don't want it being abused.
I can't tell you specifics, but I do remember my doctor explaining to me this once. Vyvanse is meant to be safer than Adderall. It's only effective up to a certain dose, if you take more than that, the entire dose becomes ineffective. Something about enzymes maybe. I do know it's absorbed completely different than Adderall, so I think that has something to do with it.
 
Vyvanse - dextroamphetamine - is a pro-drug: meaning it needs to be converted by the liver into the actual drug (something-amphetamine, I forget currently) to take effect.

As mentioned in the other thread you made - your liver is bombed; take it easy on the DXM or other stuff (or both). DXM is a dirty, dirty drug...
 
lisdexteoamphetamine needs to be de-lysinated by, I think it's Cytochrome 450 enzyme. You can try taking your vyv w/ Tums & supplement caffeine. Other than that there's not much in the way of potentiating vyvanse. If I had to take a shot in the dark I'd say the dxm is prolly still bioactive & countering and beating out the effects that your meds would normally have, which is of course stimulating your sympathetic nervous system via Dopamine & Norepinephren release.

Edit: Oh and just to clarify, the mechanism (delysination) by which vyv is converted into dexamp is limited by time. You're liver's enzymes can only break it down at a certain rate, which means there will be a ceiling effect & after you reach that point you are simply wasting your meds. I believe it is similar to Codeine only being effective up to 400mgs.
 
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Skill said:
lisdexteoamphetamine needs to be de-lysinated by, I think it's Cytochrome 450 enzyme. You can try taking your vyv w/ Tums & supplement caffeine. Other than that there's not much in the way of potentiating vyvanse. If I had to take a shot in the dark I'd say the dxm is prolly still bioactive & countering and beating out the effects that your meds would normally have, which is of course stimulating your sympathetic nervous system via Dopamine & Norepinephren release.

Edit: Oh and just to clarify, the mechanism (delysination) by which vyv is converted into dexamp is limited by time. You're liver's enzymes can only break it down at a certain rate, which means there will be a ceiling effect & after you reach that point you are simply wasting your meds. I believe it is similar to Codeine only being effective up to 400mgs.
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This, and what the other posters said...

The DXM needs to be mostly out of your system for you to get anything out of psychostimulants. Your brain is probably pretty tired too...

Exhaustion + amphetamines = (usually) just being more awake, if anything.
 
Shady Kaity said:
I went on a three day dxm binge and yesterday I was dead exhausted. So today I thought I'd take double my dose of 70mgs of vyvanse to pick me up a little, but I feel like nothing. I've had this happen before, why am I exhausted the day after dxm and why does nothing help pick me up?

It's not just the vyvanse, before I was rxed it I would take adderall or Ritalin the day after dxm and still nothing. Same goes for any energy supplements, caffeine, ect.
Click to expand...

This odd. but i have noticed that i need to take around 200mg for a pleasant experience... actually i haven't slept in 2 days cuz of the shit and idk why because it wasn't that stimulating.. its kinda bugging me cuz im starting to become delirious..
 
I assume the levels of dopamine in your brain are too low after the dxm binge to provide the desired affects. Wait a while, take vitamins, eat healthy, exercise, rest, and then give it a go. Dose on an empty stomach or with a light protein breakfast. Do not drink or consume any acids, in fact take a tums or some sort of antacid to help the metabolization.

SunflowerCake said:
I'm pretty sure Vyvanse is actually set up to not be effective in high doses, because they don't want it being abused.
I can't tell you specifics, but I do remember my doctor explaining to me this once. Vyvanse is meant to be safer than Adderall. It's only effective up to a certain dose, if you take more than that, the entire dose becomes ineffective. Something about enzymes maybe. I do know it's absorbed completely different than Adderall, so I think that has something to do with it.
Click to expand...

As an experienced user of Vyvanse, I have to disagree; the effects I feel from taking a higher dose are not placebo. 40mg is noticeable alertness and energy, but 120mg+ has a moderate euphoria as well as extreme drive, focus, and motivation. The differences are very pronounced, however I do agree that after initial metabolization, redosing seems to have no effect other then easing the comedown, and extending the duration. Does anyone have info on why redosing does not increase the stimulation even as little as an hour after initial dosage? Also sorry to be an info fiend, but any ideas on how long of a break is needed to reset tolerance? (amphetamine only) Thanks guys.;)
 
SunflowerCake said:
Vyvanse is meant to be safer than Adderall. It's only effective up to a certain dose, if you take more than that, the entire dose becomes ineffective. Something about enzymes maybe. I do know it's absorbed completely different than Adderall, so I think that has something to do with it.
Click to expand...
I don't think that's true. Vyvanse has been used to treat ADHD in doses of 70mg and is in fact available in 70mg capsules, and it doesn't make sense that taking too much would somehow completely inactivate the entire amount. The reason Vyvanse is supposed to be less prone to misuse than other amps is because it is a pro-drug, so when you take it by any route of administration it is initially inactive, takes longer to metabolize, so the effects come on slowly and it lasts for a long time. The effects from snorting or injecting it aren't any stronger or faster than from taking it orally.
 
Sagulations said:
Does anyone have info on why redosing does not increase the stimulation even as little as an hour after initial dosage? Also sorry to be an info fiend, but any ideas on how long of a break is needed to reset tolerance? (amphetamine only) Thanks guys.;)
Click to expand...
I am not sure why re-dosing does not increase the effects, maybe something to do with the way it is metabolized or the way it affects the brain? This does seem to happen with quite a few different types of drugs.
Apparently just a few days should reduce your tolerance but I have heard you can also take things like magnesium supplements or memantine (however that one requires a prescription), and rapidly reduce or reset your tolerance, so you might want to do some research on that.
 
Swimmingdancer said:
I am not sure why re-dosing does not increase the effects, maybe something to do with the way it is metabolized or the way it affects the brain? This does seem to happen with quite a few different types of drugs.
Apparently just a few days should reduce your tolerance but I have heard you can also take things like magnesium supplements or memantine (however that one requires a prescription), and rapidly reduce or reset your tolerance, so you might want to do some research on that.
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This is great information. And yeah, for tolerance, it really does only take maybe About three days break to get desired effects again.
And that's a great tip about the magnesium! Thank you! About how quickly do the effects take place? How much magnesium should be used? And will taking the magnesium after already taking the vyvanse today help?
Also, I have heard that dxm helps lower tolerance as wel
 
Shady Kaity said:
This is great information. And yeah, for tolerance, it really does only take maybe About three days break to get desired effects again.
And that's a great tip about the magnesium! Thank you! About how quickly do the effects take place? How much magnesium should be used? And will taking the magnesium after already taking the vyvanse today help?
Also, I have heard that dxm helps lower tolerance as wel
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I haven't personally tried it, I've just heard about it. Supposedly you just take about 500mg+ of magnesium a day and it can be done even while you continue to take Vyvanse. However, I did read somewhere that it can be slightly unsafe to take over 400mg of magnesium a day (although I do know people who take more than that with no noticeable adverse effects). I'd be interested to know whether it helps for you, I can't personally make any claims about the efficacy. Another poster on BL said they took DXM resulting in noticeable reduction of tolerance. I think any NMDA antagonist should theoretically help.
 
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