Letting a Prepped Shot Sit Over Night

[animalpee]

Have you already prepared your hydrocodone in water? Ideally you should be doing a cold water extraction to remove the APAP and fillers, and then use a micron filter to filter it. Or are you now planning on administering it rectally instead of by injection?

Rectally.

 

[Cane2theLeft]

Sorry but I haven't a clue if apap will burn rectally as I've never plugged any. It'd be a good idea to CWE it if you are taking more than 1-2g though anyway.

 

[animalpee]

The only place I have ever heard that is on online drug forums like Bluelight. When I used to inject heroin I would occasionally do a shot that had been prepared the night before and I noticed no difference in effects or potency.

This is the best answer from a scientific source I could find:



Basically I think it is saying that it converts to 6-monoacetylmorphine, not morphine, that it converts very slowly (only 4%-13% was changed in 24 hours), and that how fast it hydrolyzes depends on a number of factors, including the acidity of the solution. 6-monoacetylmorphine is actually more potent than heroin (see: http://www.ncbi.nlm.nih.gov/pubmed/6543399) . Your brain converts heroin into 6-monoacetylmorphine and then to morphine when you inject heroin anyway.

Couldn't remember the specifics, it just made me think that maybe that was also the case for hydro

 

[animalpee]

Sorry but I haven't a clue if apap will burn rectally as I've never plugged any. It'd be a good idea to CWE it if you are taking more than 1-2g though anyway.

Only 650 mg of apap. I'll just shoot a little up there to test it out, I'll report back whether or not it burns for future reference.

 

[Swimmingdancer]

Rectally.

Oh that's good.

Couldn't remember the specifics, it just made me think that maybe that was also the case for hydro

I know, I was just doing some research on whether or not it was actually true that heroin converts to morphine when left in water for the interest of my own curiosity and and anyone else reading. For example, SugarHill was curious. I would say it is probably just a Bluelight rumour because it doesn't seem to be mentioned anywhere in reliable scientific literature.

 

[animalpee]

Oh that's good.

I know, I was just doing some research on whether or not it was actually true that heroin converts to morphine when left in water for the interest of my own curiosity and and anyone else reading. For example, SugarHill was curious. I would say it is probably just a Bluelight rumour because it doesn't seem to be mentioned anywhere in reliable scientific literature.

Oh yeah, I hear you man. But nice job finding that info, I didn't have much luck, nor do I understand half of that article lmao

 

[animalpee]

Just plugged the solution, no burning at all, no irritation, feels a bit stronger than the same dose orally, for anyone curious.

 

[SugarHill]

Oh that's good.

I know, I was just doing some research on whether or not it was actually true that heroin converts to morphine when left in water for the interest of my own curiosity and and anyone else reading. For example, SugarHill was curious. I would say it is probably just a Bluelight rumour because it doesn't seem to be mentioned anywhere in reliable scientific literature.

yea it just doesnt seem logical that it would be tha easy to get it into its morphine stage... what wud give me a better rush anyway ? the morphine or the dope

 

[Tripman]

also, who told you that heroin turns into morphine when sat in water too long?? ... im not saying your wrong im just simply curious because i never heard that before and thats a pretty cool fact if its true

Over time Heroin in water or blood(much more rapidly) will be hydrolysed by sequential deacylation of two ester bonds to yield first 6-monoacetylmorphine then morphine.

Abstract

A kinetic study of heroin hydrolysis in alkaline aqueous solution at room temperature was conducted by a gas chromatographic method to measure the consecutive reactions of diacetylmorphine to monoacetylmorphine and of monoacetylmorphine to morphine. A first-order reaction was observed in both instances, and the rate for the deacetylation of heroin was greater than that of monoacetylmorphine.

Source: http://www.sciencedirect.com/science/article/pii/S0021967300912135

It must be noted that this was done in Alkaline aqueous solution which means a higher PH than normal.