Opioids tolerance question

[sludgefactory101]

hey everybody,

i want to know how long it will take for my opiate tolerance to go down. ive been using opiates at least 3 days out of the week for the past 3 or 4 months and was using 20mg of oxycodone most of those days. After running out of oxy's i used hycodan and was using 40-50mg of hydrocodone out of the bottle each time. so i was wondering how long it would take for my tolerance to go down. thanks


edit: i should add that this past week i went on a 4 or 5 day binge using the 40-50mg hydrocodone and a 5 mg oxy pill those nights

 

[Tommyboy]

You can take a few weeks off and you should get high off of the 20mg of oxycodone again, but your tolerance will go right back up if you use regularly. The first high after a little break is good, but you really need to keep your use to once a week if you want your tolerance to stay down.

Even if you took a longer break (several months), the same would be true (tolerance would drop for the first few times, then go right back up) even if you just went back to using 3 days a week, although you would get a few more highs in compared to the 2 week break before your tolerance ends up back to where it is now.

Luckily your tolerance isn't that high right now, so your best bet is to take a few weeks off, and then only use once a week, or twice a week max. If you take a few months off then you might be able to use 2-3x a week for a couple of weeks before your tolerance is back up, as opposed to taking a few weeks off where using 3x a week would have your tolerance back up very quickly.

A tolerance break is only effective if you moderate your use more when you go back to using. My rule is to limit your use to a max of 2 days a week, and those days can't be in a row or you will get a lot less high the second day in a row. This works to avoid physical dependence as well, since using 3 days or more a week usually results in becoming dependent on the drug. I knock it down to 2 days a week for the sake of keeping tolerance down, and staying on the safe side of dependence.

 

[tricomb]

If you can stay off opioids for 3 weeks, that should be enough to begin to notice a "significant" difference, YMMV. Consecutive dosing, as Tommy described, is one of the major causes of tolerance building, when your body has a somewhat constant/regular levels of opioid administration, it's going to get used to them and develop what we call tolerance. Tolerance in a way, is your body's self defense mechanism to the foreign chemical you are administering.

Are you a legitimate chronic pain patient? If so, you will really need to take a look in the mirror and do an assessment. I had to, it's not the most pleasant reality, but these are drugs I will need my entire life. The keywords are need, and entire life. If I continued to abuse opioid medications in a manner that I could not manage my addiction AND my pain on my own prescriptions, I would be fucked royally if I could not obtain more narcotics than what is prescribed to me. This behavior, contrary to what I had rationalized, was reckless. Extremely reckless. I did an assessment and cut back on abusing medications, both my own and others, but especially others, I am very proud not to be dependent on narcotics not prescribed to me. You should look into NMDA antagonism and the roles it plays in preventing tolerance from growing.

If you're not a legit CPP and are just abusing someone elses medications, disregard the second paragraph. I sincerely hope you are not obtaining them in a way that causes harm, like someone else to run out of their pain medication early. Please read up on how to safely use these drugs, they are potent opioid narcotics and should be treated as such.

 

[Swimmingdancer]

You should look into NMDA antagonism and the roles it plays in preventing tolerance from growing.

What is your take on the safety of using NMDA antagonists? I've been reading lately that they cause brain damage. For example, apparently in medical settings where a strong NMDA antagonist is used they concurrently administer GABA-A receptor agonists to help prevent brain damage. Is this only at high doses that it can cause neurotoxicity or just not widely accepted or something?

 

[tricomb]

I have only recently in the past few weeks begun to use low dose (15-30mg dextromethorphan over 12 hours) NMDA antagonists, and am hoping my dosing is too low to be considered a "strong NMDA antagonist". To my understanding DXM is not the strongest NMDA antagonist, I believe that Memantine is much more potent on NMDA antagonism.

 

[Rabbit]

I've used DXM to help prevent tolerance:

IME it works and is pretty safe as long as you keep the doses low. I used anywhere from 15-50mg a day last year as tolerance will build over time.

These days I use 15-30mg 3 days a week (spaced out). DXM products contain a lot of other crap so you don't want to consume a lot of it.

I am talking about inactives like sorbitol. For example robogels give me awful smelling gas so I prefer not to take it very often .

2nd and 3rd plat. trips can be good for w/d and beating addiction to opiates IME but again it must be used correctly and is not a magic cure or an answer to all your problems. It's a tool and you must use it like one.

1st plat. isn't as useful IME for w/d but it will help a little. I tried it once and it was basically like going through the worse part of W/D for 8 hours. Felt well enough the next day to eat and be around family but the day after I was back to feeling like crap. I was using A LOT of oxycodone at that time though.

Also after a trip your tolerance will be greatly reduced for a few days and maybe longer (not sure because I always started using again after my trips ;/ last year) so be careful if you take your DOC after a dxm trip.

 

[xxxyyy]

when i think back how my tolerance used to be - and it was still pretty benign compared to some people here - i don't think you should have too big of a problem getting back to 'normal'. not to discourage you or anything, but while it will drop a lot, it will never go back to what it was before you started using. i don't know if this is the same for everyone, or for every drug, but i know quite a few people, regardless of drug preference whose tolerances were still much higher after extended periods of sobriety, and very quickly reach the point they were at at their most rampant drug abuse. This is pretty much the same with me. but no matter how long i abstain from benzos and opiates, i need to take quite a bit more of those substances to get the same effect compared to someone who never used them or only really occasionally.
also, this might be different from drug to drug, but case in point, even after a year or two without benzos i need at least 3-5mgs of alprazolam to feel anything enjoyable, and after not any taken opiates for one or two years, i mainlined 2mgs of subutex. a lot of people told me that that should have at least caused respiratory depression if not a full blown OD, and these were people who are much more immersed in the drug culture. also, i had 6mgs of xanax, 5 strong vodka martinis, half a gram or heroin (snorted - but the bupe probably overrode that). i'm not trying to boast or anything, as high tolerance really is nothing to be proud of, i'm just saying, for me and a lot of people i know, even extended periods of sobriety is not is seen more as something to save money and not to bring your tolerance back to what it was before all the drugs.
god, the first time i took a benzo (10mg dia) and fucking hell, that was absolutely relaxing and fun as shit. if i drop 10mg of the stuff now, even if i hadn't had a benzo in years, its effects are so marginal, short lived and unfulfilling. sort of how i image valerian root feels to normal people.
my educated guess is that it has a lot to no with neural plasticity, but then i understand most of the human body (and especially the brain chemistry) a lot less than i'd like to

 

[xxxyyy]

dextromethorphan.

I have only recently in the past few weeks begun to use low dose (15-30mg dextromethorphan over 12 hours) NMDA antagonists, and am hoping my dosing is too low to be considered a "strong NMDA antagonist". To my understanding DXM is not the strongest NMDA antagonist, I believe that Memantine is much more potent on NMDA antagonism.

hey, i'm genuinely curious about this. DXM is available as a cough syrup here, with 100mg DXM inside, but most pharmacies won't sell you one or two. i took it a few times, mainly as a sleeping aid during GHB withdrawal - god i was desperate - and 100-200mg kinda knocked me out for a while with really weird dreams/closed eye hallucinations. then i once drank four bottles - god that shit tastes godawful, imagine some vile chemical caramel taste with a plethora of other, much worse tastes. and it had the consistency of some weird jello/slime mutation, with an excrutiating bitter, slightly caustic liquid running sloshing around in their.

anyway, sorry, i did't think DXM was active at all at those dosages, i mean 100mg just made me a bit sleepy and fucked in the head.
sorry, i know i could have formulated much, much, much shorter, so what did that do for you?

also, i know very little about ndma agonists, but i was always under the impression that phencyclidine was the most potent?

 

[sludgefactory101]

thanks for your replies everybody. So if i stop doing it for like a month or 2 i should be fine with 10-20mg of hydrocodone too? or is there no hope for that one. Also i dont steal anyone elses pain pills. I got the oxy's from a person who did not want them so they just gave them to me. I also get prescribed hycodan every 8 months or so because i get some nasty colds. and the vicodens i got were for back pain from a recent car wreck. but they also gave me gabapentin which is kind of working. so im saving the vikes for a rainy day

 

[ahkwa]

Yeah ime the more you binge the higher it gets and the more you wait the more it goes down. It can only go so low. Id atleast wait 2 weeks. Trust me opiates are amazing and if you want to keep the amount of money you spend low keep your using them to a minimum. Tolerance blows.