Why are psychedilcs so long lasting im general

[Roger&Me]

Psychedelics are so long lasting because they elicit their effects via an intracellular secondary messaging cascade in cortical pyramidal cells, that is initially catalyzed by agonism of 5-HT2A receptors on cortical pyramidal cells and deep layer cortical pyramidal cells that signal for glutamate release (this glutamate release then activates NMDA and AMPA receptors on cortical pyramidal cells, which further perturbs secondary signalling processes).

When you take LSD, you will excrete nearly all of it well before the trip is over. In the case of the psychedelics, the actual trip results from the nonhomeostatic behavior of the system that is elicited by that initial perturbation -- the compound doesn't need to stick around for any appreciable length of time to make stuff happen.

 

[gymstud]

Psychedelics are so long lasting because they elicit their effects via an intracellular secondary messaging cascade in cortical pyramidal cells, that is initially catalyzed by agonism of 5-HT2A receptors on cortical pyramidal cells and deep layer cortical pyramidal cells that signal for glutamate release (this glutamate release then activates NMDA and AMPA receptors on cortical pyramidal cells, which further perturbs secondary signalling processes).

When you take LSD, you will excrete nearly all of it well before the trip is over. In the case of the psychedelics, the actual trip results from the nonhomeostatic behavior of the system that is elicited by that initial perturbation -- the compound doesn't need to stick around for any kgappreciable length of time to make stuff happen.

Thanks that answers my op
mostly but dont ither drugs do that or is just other long acting ones

 

[burn out]

Psychedelics are so long lasting because they elicit their effects via an intracellular secondary messaging cascade in cortical pyramidal cells, that is initially catalyzed by agonism of 5-HT2A receptors on cortical pyramidal cells and deep layer cortical pyramidal cells that signal for glutamate release (this glutamate release then activates NMDA and AMPA receptors on cortical pyramidal cells, which further perturbs secondary signalling processes).

When you take LSD, you will excrete nearly all of it well before the trip is over. In the case of the psychedelics, the actual trip results from the nonhomeostatic behavior of the system that is elicited by that initial perturbation -- the compound doesn't need to stick around for any appreciable length of time to make stuff happen.

This is incorrect. LSD has a half life of three to five hours. Assuming your trip lasts 8 hours, you will still have ~25% of your initial dose remaining in your system when the trip is over. Furthermore, according to your theory could you explain why the route of administration makes such a difference in the duration of say, DMT?

 

[<SpaceHead>]

With drugs like 2cb at 4-6 being concidered short acting what is it about this class of drugs that majes it last so long

There are drugs that last longer than any psychedelic, the anti-psychotic haloperidol lasts for about a month with one dose i think. In a way it's almost the opposite of a psychedelic drug.

 

[burn out]

Buprenorphine is another drug that lasts for days.

 

[Roger&Me]

This is incorrect. LSD has a half life of three to five hours. Assuming your trip lasts 8 hours, you will still have ~25% of your initial dose remaining in your system when the trip is over. Furthermore, according to your theory could you explain why the route of administration makes such a difference in the duration of say, DMT?

The information I gave is correct to the best of my knowledge -- and its hardly "my theory", its clearly defined in the literature. For an overview of the importance of secondary signalling processes in the action of psychedelics, I suggest checking out:

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders
by Franz X. Vollenweider and Michael Kometer
Nature, volume 11 (2010) pp.642-651

and/or

Hallucinogens
by DE Nichols
Pharmacology & Therapeutics, volume 101 (2004) pp.131–181

And 8 hours is an understated figure for the duration of an LSD trip. Most people feel initial effects for about 12 hours, with aftereffects/heightened perception lasting at least a day if not longer. It is well documented that in most individuals, the effects of LSD persist even after the drug has been eliminated to levels below its ED50.

In reference to your comment regarding DMT, how do you mean? DMT lasts roughly the same amount of time when smoked, injected, or snorted -- and when taken orally, you must necessarily add an MAOi into the mix which will change the pharmacology of the compound.

The effects of psychedelics are elicited by a secondary signalling cascade, the role of 5-HT2A agonism is just to catalyze the cascade initially. If you remain unconvinced, consider purchasing (or torrenting, or borrowing from the library) a copy of the aforementioned papers which will confirm this.

 

[burn out]

I am not doubting that the effects of psychedelics are elicited by a secondary signalling cascade but I saying that it is simply not the case that nearly all the LSD is exreted long before the trip ends. According to erowid, LSD doesn't even reach peak plasma concentrations until 3 hours post ingestion (http://www.erowid.org/references/refs_view.php?ID=6265). Furthermore, 8 hours is not necessarily an understatement. You said the "trip ends" not "until all the residual effects have completely disappeared". My LSD trips usually end around 8 hours, sure I cant sleep for a while after that but im not really tripping any more. Even if we go with 16 hours, there would still be an active amount of LSD amount in the plasma at that time, despite the "trip" being over. And snorted DMT lasts several times longer than smoked. Why is this?