If an opiate-naive person were to take 300mg (i heard the dose to get high off them is 150mg so i'm doubling it), would he nod off?
Can you do that on codeine?
^ depends on several factors - primarily the person's natural tolerance and how well they metabolise codeine. It's complicated - 5-10% is converted to morphine - some people are good metabolisers and produce more, some lack the enzyme entirely - and there is another active metabolite, codeine-6-glucuronide, which is responsible for at least some (if not most) of it's opioid activity. It's really variable from person to person. I usually recommend 100-200mg for a starting dose.. 300mg could make someone naive/sensitive noddy (and probably vomit too). Codeine is also incredibly itchy, moreso than many other opioids, so antihistamines are v useful.
Remember to advise people not to mix it with benzos or alcohol
Funny thing with me, is if i take a dose of DHC that would get my high, then pop 4 codeine within half an hour i'm nodding, by the time i hit 2 hours the nod is gone... so i'm giving credit to the codeine.
opiates are alkaloids that come "naturally" from the poppy (morphine, codeine, thebaine). opioids include natural and "processed" opiates, i.e. semi synthetic (heroin, oxycodone, hydromorphone etc), and synthetic (fentanyl, methadone etc)
so all opiates are opioids but opiate refers to a specific category of opioids.
so tramadol + codeine = increased risk of respiratory depression if i've understood right, i'm sorry for asking so many times, i just wanna be sure i know what i'm talking about when i'm talking to someone about this kinda stuff