Is preloading an Alprazolam (Xanax) with a Phenethylamine Psychedelic dangerous ?

[Kishka]

Hey

Ok, can sounds stupid but I would like to know if there is absolutely no problems (regarding health and cardiovascular aspects) taking an Alprazolam like 20 - 30 minutes before taking a trip (Phenethylamine ) ? I tried 2C-T-7 last time but the come up was rough and had a bad time to deal with it really ...(likely ruined the whole trip).

So I'm wondering if the interactions Alprazolam (Benzo's) - PEA can be life threatening or something I should avoid with PEA or DOx ?

It will just "dilute" the trip right ? I used to take Alprazolam but ONLY after a trip or something so... (Anyway I took Alprazolam since a long time so...)

Thank you!

 

[NeighborhoodThreat]

It is not dangerous to combine alprazolam with psychedelics.

 

[Kishka]

Even the stimulating one ?

 

[IamMe90]

I'm pretty sure we've already told you NOT to stop taking your prescribed benzo regimen before taking a psychedelic. And no, preloading with a benzo will have no dangerous interactions with stimulating psychedelic phenethylamines.

 

[Cyanoide]

Even the stimulating one ?

No, it's not dangerous.

I've mentioned it before but it's worth mentioning again, especially for those not that experienced with psychedelics. Do not take beta blockers for anxiety with phenethylamines. They're perfectly fine with tryptamines (except AMT and 5-MeO-AMT) but not with phenethylamines - this can be potentially life-threatening. Benzos are physically totally safe.

 

[Roger&Me]

Even the stimulating one ?

No, its not even dangerous to combine xanax with a strong stimulant like methamphetamine. The whole "mixing uppers and downers is dangerous" thing is only true for opiates+stimulants, not benzos+stimulants -- adding a benzo to a stimulant actually decreases the stimulant's toxicity.

So xanax is fine to take with psychedelics, but it will probably diminish all the of the true psychedelic effects; so really, its just boring and pointless to take it with psychs.

 

[Cyanoide]

No, its not even dangerous to combine xanax with a strong stimulant like methamphetamine. The whole "mixing uppers and downers is dangerous" thing is only true for opiates+stimulants, not benzos+stimulants -- adding a benzo to a stimulant actually decreases the stimulant's toxicity.

So xanax is fine to take with psychedelics, but it will probably diminish all the of the true psychedelic effects; so really, its just boring and pointless to take it with psychs.

I don't have experiences with any other DOX than DOB but I guess alprazolam could make some sense if there's lot's of anxiety during the come-up of, say, DOC. Alprazolam's effects will almost totally be gone while the effects of most DOX's still are building up. Long-acting benzos are a different thing though, generally I see no reason to take them with psychs if you have access to short-acting ones like alprazolam. And even short-acting ones should generally be for emergency cases IMO. I always feel anxious and uneasy on the comeup on acid (I know, off-topic here since it's not a phen) but never thought of taking benzos to reduce it. I've just accepted it as a property of LSD that goes away in 1-1,5 hours or so.

 

[Kishka]

Thank! Anyway I have a prescription for Xanax since a long time so... But I planned to pop one just shortly after taking the 2C-T-7 because I can't deal with the come-up and it ruined my trip. I want to check the force of 2C-T-7, so I was thinking of preloading an Alprazolam to reduces anxiety.

 

[Cyanoide]

Thank! Anyway I have a prescription for Xanax since a long time so... But I planned to pop one just shortly after taking the 2C-T-7 because I can't deal with the come-up and it ruined my trip. I want to check the force of 2C-T-7, so I was thinking of preloading an Alprazolam to reduces anxiety.

If you don't want to dull the trip, I guess it would be best to time the ingestion of alprazolam so that its effects are gone after the come-up. So rather than taking alprazolam after taking 2C-T-7, why not take it an hour or two before?

 

[Roger&Me]

I don't have experiences with any other DOX than DOB but I guess alprazolam could make some sense if there's lot's of anxiety during the come-up of, say, DOC. Alprazolam's effects will almost totally be gone while the effects of most DOX's still are building up.

I dunno, I feel "off" for a day or so after taking alprazolam. Its pretty short acting when compared to other benzos, but its not that short acting IME. Of course its a matter of personal preference, but I've always found benzos to kill that "sparkle" that psychs have -- you'll still trip, but the cosmic edge is not as sharp. Just my opinion, though

 

[Solipsis]

You can do that but it shouldn't be too much alprazolam or you can experience withdrawal which is not a good option combined with something like 2C-T-7, you can get hypertension and what not and at the very least feel bad. Also I don't know of a benzo that doesn't have gradually disappearing / fading effects, don't most metabolites have mild action as well? As long as they are acting the trip will still be dulled.
I don't logically see how you can be on a xanax script and avoid the consequences of either taking that xanax or withdrawing from it. On the other hand cyanoide does make a good point that taking 'more than enough' xanax or taking it timed late won't help you get good psychedelic effects either.

I think it's best for you to take it easy with the psychedelics, though I am not sure how much anxiety you experience nowadays... if it's getting better then maybe thats your cue to lower your script (discussing it with your psych first of course). For people who can handle their shit, upping the psychedelics dose and matching it with a good but mild sedative dose can produce a nice grand total of effects when added up... but this can go wrong and should be checked with great care.

If it wasn't for your script there would be other options that can help to relax on comeups without dulling other effects too much, but it doesn't seem like such a good idea to suggest any of that in this case.

 

[Kishka]

Hi thanks for all your replies !

What do you think instead of taking a xanax, drinking a couple of beers or 2-3 shots of alcohol to ease the come-up ? Will it be worse or more relax ?

Thanks! 2C-T-7 is really intruiging, I still want to give it a try !

 

[Cyanoide]

Hi thanks for all your replies !

What do you think instead of taking a xanax, drinking a couple of beers or 2-3 shots of alcohol to ease the come-up ? Will it be worse or more relax ?

Thanks! 2C-T-7 is really intruiging, I still want to give it a try !

Alcohol is IME even more confusing than benzo's. Although I admittedly almost always drink a couple of beers while tripping, because it tastes so heavenly good on psychs. The senses (including taste) are heightened so much you notice even small details you normally wouldn't. I've sometimes been absolutely mesmerized, to the point of confusion, of eating or drinking something good on a trip.

If you really have to choose I'd say stick with the benzo. Alcohol makes you even more dull, and slightly intoxicated. Benzo's are more clear-headed, if you even can use that word about them. And lastly, benzo's are superior for anxiety, while alcohol can be more unpredictable.

Why not start with a very low dose to get more familiar with the compound? A large dose of LSD would make the come-up very tough for me, if I wouldn't be a bit familiar with how it works. I just accept anxiety is part of the come-up.

Have you ever tried meditation, yoga or other techniques to relax?

 

[Kishka]

Yes but I can't. Infact when I start to feel the first physical effects (I didn't know really what 2C-T-7 will do in my body). I started to be nervous, stimulated, walking around in circle with hot flashes (feels very hot). And I start panicking. I always think something is wrong or it's not the effects I should have compared to what I have read on Internet.

 

[Cyanoide]

Yes but I can't. Infact when I start to feel the first physical effects (I didn't know really what 2C-T-7 will do in my body). I started to be nervous, stimulated, walking around in circle with hot flashes (feels very hot). And I start panicking. I always think something is wrong or it's not the effects I should have compared to what I have read on Internet.

Then go with the benzo. But skip the alcohol, it messes with your mind more (in moderate doses) than benzo's. Alcohol really dulls trips much more IME, and can make them unpredictable and more messy.

Also, if you really get that bad anxiety, maybe it just isn't a compound that goes together with your mind and body. We all have psychs that don't go well together with our unique psyches and mindsets. I mean, you don't have to like 2C-T-7. If your mind and body rejects it, you can't force yourself to like it. The world of psychedelics is vast and rich in variation, through trial and error we all find the ones that are really special.

 

[Kishka]

Yes of course, but it seems very strange that the body "rejects" the compounds. I mean, the psychedelics effects are largely due to the mindset and not due to the body itself right ? So that's mean a type of compounds can't suit with a body ? In any ways (so with a benzo for exemple) ?

Because I "mainly" feel restless and nervous with every psychedelics during the come-up but some compounds have a more predominant effect in that aspect (much more nervous) than others. But I can deal with it, except some like the 2C-T-7 I tried for the first time.

 

[Bagseed]

i don't think that the 2c-t-7 itself makes you anxious but that you cannot deal with the bodyload. stimulation and hotflushes sound like the normal come-up i experience with 2C-E. it's not dangerous, only a bit unpleasant, but if you get nervous about it, you will only focus on the bodyload which will make it appear more intense and "dangerous". you should learn to deal with it or rather try other psychedelics less prone to bodyload (alltough i have a hard time suggesting someone with anxiety to take psychedelics at all).

 

[Cyanoide]

Yes of course, but it seems very strange that the body "rejects" the compounds. I mean, the psychedelics effects are largely due to the mindset and not due to the body itself right ? So that's mean a type of compounds can't suit with a body ? In any ways (so with a benzo for exemple) ?

It's not that strange. My body physically rejects almost all 5-MeO tryptamines (as with many phenethylamines), they induce a horrible bodyload, nausea, vomiting, tremors etc. The psychedelic effects are largely due to the mindset, yes, but then there's the bodyload that can be unbearable with some compounds.

So yes, some compounds don't just go together with your brain (the bodyload is also "produced" by your brain reacting to the compound). Some compounds just don't fit the mind, whatever the mindset and set & setting. For me DPT is such a compound. Numerous times I've tried to make it my "friend", in different environments, but it always results in non-enjoyable experiences. DPT always fucks around with my personality. No amount of benzo's would make 5-MeO-MiPT tolerable for me; it's non-stop vomiting and tremors for 6 hours. Our brains are unique and so are our reactions to psychedelics.

 

[Kishka]

Thank you ! I think I understood Anyway, I will let another try with 2C-T-7 tomorrow !

I would like to try many research chemicals. So I will also try the 5-meO series!

Thanks

 

[psood0nym]

Yes of course, but it seems very strange that the body "rejects" the compounds.

Some people are convinced it's all the the head, but there's some theoretical warrant for thinking that 5-MeO tryptamines are harder on the body beyond just the mindset of the user. This may be because the 5-MeO tryptamines are closer in structure to serotonin than other tryptamines. Serotonin's chemical name is 5-hydroxytryptamine (5-HT), so 5-MeO tryptamines are really close, because serotonin has a wide array of effects in the body -- it's involved in GI disturbances like nausea and other fun stuff -- it's likely that ingesting a 5-MeO tryptamine is going to activate some serotonin receptors in a more generalized way than more selective psychedelics. We have serotonin receptors in our intestines that some psychedelics, especial 5-MeOs, may set off. In fact psychedelic toads excrete 5-hydroxydimethyltryptamine (5-ho-DMT) as venom to exploit this structural similarity and make some animals that eat them sick. You can smoke their dried skin and get a kind of shitty trip, but you wouldn't want to eat a whole toad. I've heard some good stuff about 5-MeO-MiPT, and I like 5-MeO-DMT, but in general the 5-MeOs have more side effects than most other psyches.