LSD interactions

[D7CE]

I take pimozide, cogentin and strattera. Will I still trip if I take a couple tabs?

 

[Solipsis]

Probably not, pimozide is a very potent antipsychotic that will counteract the LSD.

But do NOT try to take a large dose to trip anyway since it can be very unpredictable and have possible adverse peripheral effects
and very importantly: you probably aren't taking those medications for fun, but for a reason that most likely goes very bad together
with psychedelics.

Seriously I'd forget about it. Sorry.

 

[D7CE]

well thanks anyways

 

[Foreigner]

Probably not, pimozide is a very potent antipsychotic that will counteract the LSD.

But do NOT try to take a large dose to trip anyway since it can be very unpredictable and have possible adverse peripheral effects
and very importantly: you probably aren't taking those medications for fun, but for a reason that most likely goes very bad together
with psychedelics.

Seriously I'd forget about it. Sorry.

I'm sure there is a FAQ thread somewhere about this, but can you point me toward more info about how anti-psychotics help with psychosis? I want more of a neurochemical/scientific analysis. I don't really understand the neurochemical basis for psychosis either.

 

[Solipsis]

I'm sure there is a FAQ thread somewhere about this, but can you point me toward more info about how anti-psychotics help with psychosis? I want more of a neurochemical/scientific analysis. I don't really understand the neurochemical basis for psychosis either.

I didn't find a FAQ in our own Drug FAQs section, but here is a wiki quote that should help. Other than that, just google the hell out of it.

Psychosis has been traditionally linked to the neurotransmitter dopamine. In particular, the dopamine hypothesis of psychosis has been influential and states that psychosis results from an overactivity of dopamine function in the brain, particularly in the mesolimbic pathway.

The two major sources of evidence given to support this theory are that dopamine receptor D2 blocking drugs (i.e., antipsychotics) tend to reduce the intensity of psychotic symptoms, and that drugs which boost dopamine activity (such as amphetamines and cocaine) can trigger psychosis in some people (see amphetamine psychosis).[63]

However, increasing evidence in recent times has pointed to a possible dysfunction of the excitory neurotransmitter glutamate, in particular, with the activity of the NMDA receptor. This theory is reinforced by the fact that dissociative NMDA receptor antagonists such as ketamine, PCP and dextromethorphan/dextrorphan (at large overdoses) induce a psychotic state more readily than dopinergic stimulants, even at "normal" recreational doses. The symptoms of dissociative intoxication are also considered to mirror the symptoms of schizophrenia, including negative psychotic symptoms, more closely than amphetamine psychosis.
Dissociative induced psychosis happens on a more reliable and predictable basis than amphetamine psychosis, which usually only occurs in cases of overdose, prolonged use or with sleep deprivation, which can independently produce psychosis. New antipsychotic drugs which act on glutamate and its receptors are currently undergoing clinical trials.

The connection between dopamine and psychosis is generally believed to be complex. While dopamine receptor D2 suppresses adenylate cyclase activity, the D1 receptor increases it. If D2-blocking drugs are administered the blocked dopamine spills over to the D1 receptors. The increased adenylate cyclase activity affects genetic expression in the nerve cell, a process which takes time. Hence antipsychotic drugs take a week or two to reduce the symptoms of psychosis. Moreover, newer and equally effective antipsychotic drugs actually block slightly less dopamine in the brain than older drugs whilst also blocking 5-HT2A receptors, suggesting the 'dopamine hypothesis' may be oversimplified.[64] Soyka and colleagues found no evidence of dopaminergic dysfunction in people with alcohol-induced psychosis[65] and Zoldan et al. reported moderately successful use of ondansetron, a 5-HT3 receptor antagonist, in the treatment of levodopa psychosis in Parkinson's disease patients.[66]

source = http://en.wikipedia.org/wiki/Psychosis#Pathophysiology

What you are taking, pimozide.. blocks the following receptors:

Extremely strong blocking: D2 (dopamine)
Strong blocking: D3 (dopamine), α1-adrenergic, 5-HT2A

Psychedelics typically have primary action on 5-HT2A which is why it is pharmacologically contraindicated to begin with.

 

[bupropion]

I take pimozide, cogentin and strattera. Will I still trip if I take a couple tabs?

Does the pimozide work? Does it make you feel more organized, like Haldol or acepromazine(cat tranquilizer)? Does it reduce mouth/tongue/jaw movements and/or eye spasms? Does it control psychotic symptoms if you have those?

 

[D7CE]

I take a low dose of Pimozide (1mg)2x a day. It helps with organizing my thoughts, yields relief from delusions and paranoid as well as helping with negative symptoms like anhedonia and flat-effect. A lot of sedating antipsycotics are great at treating positive symptoms like delusions and hallucinations but often make those negative symptoms worse, well at least for me. It is unique because it is not sedating due to its inhibition of the dopamine transporter (DAT) which is responsible for its stimulating effects. The inhibition of dopamine-reuptake may be the reason why it has a synergystic effect when taken with a stimulant. I can say with authority that it mixes well with my ADHD meds and also with marijuana. It can reduce tics from tourettes and is used as a treatment for them. I use it for schizophrenia and it's been the most effective drug Ive tried so far and I've tried dozens of them.

http://en.wikipedia.org/wiki/Pimozide

 

[Asante]

D7CE, this from an empathic point of view.. If you have known schizophrenia, I really wouldn't tinker with psychedelics or other strong mind altering drugs. Even if you disregard Dopamine and Serotonin, Psychedelics like LSD can supply you with sudden highly stressful experiences. Those should be avoided at all cost with schizophrenia, because intense stress can cause or worsen a psychosis in schizophrenics, even when there is no drug in play. One particularly intense trip, good or bad, can park you smack in the middle of a psychotic break lasting weeks or months and may require hospitalization. Not worth it IMHO.