As many of you know (at least from reading the title of this post!) JDTic is the world's first orally active kappa antagonist. It is highly selective at kappa. Kappa is part of the opioid system which binds to dynorphin, which seems to be responsible for anhedonia, anxiety/stress, depression, and various forms of aversive experience. It is implicated in heroin and cocaine addiction. I don't know of any reports of its use in humans, but I would love to hear people's ideas about JDTic. I think it is likely to be a very exciting compound. The preclinical animal data is certainly very interesting. For reference, Salvinorin A is an agonist at kappa, and we all know about scary salvia trips (although i is also a D2 partial agonist...) There is also data on kappa knockout mice as well as mice which do not produce dynorphin which is promising.
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RCs JDTic - The first orally active kappa antagonist
- Thread starter jdtic
- Start date
King Hop Head
Bluelighter
Isn't Buprenorphine a Kappa receptor antagonist, one of the resaons for its antidepressnt effects in many people. Is scheduled, but a popular maintenance drug for Opiate dependance.
Tchort
Bluelight Crew
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Kappa antagonism has a lot of interesting possibilities; not just on addiction treatment, but potentially other mental health problems (I'd imagine anxiety and obsessive-compulsive disorder being two likely conditions that could be researched).
It's very interesting that it's possible a kappa antagonist can help with the compulsive drug seeking behavior of cocaine addiction. Opioids have been 'easier' to predict and treat when addiction and dependancy become factors due to the metabolic changes. Upper, downer, etc addictions are much harder to treat- hopefully a lot of reseach will be done. A class of drugs that can potentially stop or greatly reduce compulsive drug seeking behavior could be the kind of modern day 'philosophers stone' of addiction treatment (what a number of substances from Ibogaine to Thephorin to Cyclazocine were supposed to be).
It's very interesting that it's possible a kappa antagonist can help with the compulsive drug seeking behavior of cocaine addiction. Opioids have been 'easier' to predict and treat when addiction and dependancy become factors due to the metabolic changes. Upper, downer, etc addictions are much harder to treat- hopefully a lot of reseach will be done. A class of drugs that can potentially stop or greatly reduce compulsive drug seeking behavior could be the kind of modern day 'philosophers stone' of addiction treatment (what a number of substances from Ibogaine to Thephorin to Cyclazocine were supposed to be).
IndustrialStrength
Bluelighter
^ I'd agree that the possibilities are quite interesting. I'd like to see more information on this.
Yea, buprenorphine does have properties as a competitive kappa antagonist but it's not fully selective as it also hits mu and delta as a partial agonist. JDTic is exciting since it actually permanently disables the kappa receptor until it can be regenerated. Because of this its effects lasts 2-4 weeks. Right now JDTic just entered Phase 1 trials in an effort to determine if it is potentially useful in cocaine dependence - PK and psychometric data are being screened. What interests me is that it might also be useful for a whole host of mental disorders. Some believe kappa antagonists could even be useful in controlling eating behavior/weight - that's interesting but not as important. The amazing idea is that it could give us the ability to dampen negative experience in the same way that mu lets us control positive experience. But unlike the other opiates, perhaps JDTic won't be addictive in quite the same way? I wonder what it feels like. The opposite of salvia?
morphonorconic
Bluelighter
Right on. Ever since I came to understand of the role of [endogenous] opioids and mental health, I've been extremely curious about kappa receptor antagonists and their potential as an antidepressant. The possibilities for such a class of drugs is staggering. Very exciting indeed.
kappazappa
Greenlighter
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Long time coming but I've been able to try JDTic. So, coming soon... the world's first JDTic trip report!
Captain.Heroin
Bluelight Crew
I love salvia trips, I don't know why I'd want to use JDTic. However if there's some benefit you guys get from it, go for it. Just do your research first.
kappazappa
Greenlighter
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Sorry, I forgot about this thread! I actually tried to post that report here but it was rejected. It isn't on the net anymore unfortunately. It wasn't written by me though, that was a report from someone else. I have tried JDTic as well and have had different experiences than in the report. I would be happy to share them here if anyone is interested. They range from only a very small noticeable experience to semi-euphoria. I have tried Sub-Q and oral ROA.
kappazappa
Greenlighter
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posted again:
Edited for privacy, 2mg q.d. for 2 weeks:
I have severe Major Depression [ed: PHQ-9 score of 22]. I have Anheodnia, no emotions, very few
feelings, and avoliton. I have severe anxiety. I can hardly speak. I only
answer questions. I do not engage in social conversations because of my severe
thought poverty and inability to process the emotional content in
conversations. I feel frozen, numb and tortured. I have to work confused,
severe memory probelms, trembling and just really screwed up. My life is a
nightmare every day of my life.
I received the JDtic one afternoon. I was so eager to try it I
divided the jdtic into 2mg dosages and put it into capsules. I tried my first dose
that afternoon. The next day I woke up feeling this really warm, clean, healthy
feeling. I felt completley free of anxiety. I kept having involuntary erections for
no reason. I never have an erection for anything. I started watching the television
and I started to have a warm feeling in my stomach from watching my favorite show. I
started to get all these feelings from my body that I never get. I started to get
cold chills from watching a movie. I started to have hunger pains. I never feel
hungry. I walked outside. The breeze felt so good that day. When I went to work. I
looked at people in the face and spoke to them without feeling frozen with anxiety.
The next day I woke up and took the next dose of Jdtic at 10am. I woke up and had
breakfast. I started to watch television. I couldn't stop laughing. I was in a great
mood. I was laughing, talking to the television. I was talking and joking with my
friends through text messages. I went out for lunch with with my only close friend
left. I kept making her laugh. It was wonderful. I've spent my whole adult life not
being able to touch anyone emotionally. Now I can make people laugh. I started to
see the punch line. I started to become really funny. That day at work. I started to
have these really brief, weak emotions. They were really weak and confusing. But I
was really happy to have them. I started to feel touched by music. I felt driven to
sing along with the music. That day I also caught myself looking at a women's
breast. I started to want to look at her body. I never do that. I usually do not
even notice women anymore. My memory also improved. I usually can't remember any of
the streets. That day I remembered all of them and thought of a plan of the best way to
get there, instead of using a gps.
The next week I planned days out with all my old friends. I wanted to be warm and
try to make them feel loved, and make them laugh. I was trying to make up for being
a cold emotionless person to them. I also went to spend time with my grandfather. My
grandfather is dying. I was too messed to go and see him. I tried my best to be warm
and affectionate to him.
The last few days of the trial. I started to have moments where I felt like my life
had a sense of urgency. I felt like I had to do things. I felt like I had to go home
and read my science books. I'm not sure if I would call it motivation. I just had
these moments where I really wanted to find my vocation in life. I was going to
college for chemical engeneering before I got sick. I just kept having this urgent
feeling that I wanted to finish.
JDTic was very helpful. I still had problems, but I was slowly starting to feel
better. I'm not sure what would happen if I continued to take it. I would love to
find out. I hope that I was helpful. I'm a little tired. I hope I remembered
everything
Edited for privacy, 2mg q.d. for 2 weeks:
I have severe Major Depression [ed: PHQ-9 score of 22]. I have Anheodnia, no emotions, very few
feelings, and avoliton. I have severe anxiety. I can hardly speak. I only
answer questions. I do not engage in social conversations because of my severe
thought poverty and inability to process the emotional content in
conversations. I feel frozen, numb and tortured. I have to work confused,
severe memory probelms, trembling and just really screwed up. My life is a
nightmare every day of my life.
I received the JDtic one afternoon. I was so eager to try it I
divided the jdtic into 2mg dosages and put it into capsules. I tried my first dose
that afternoon. The next day I woke up feeling this really warm, clean, healthy
feeling. I felt completley free of anxiety. I kept having involuntary erections for
no reason. I never have an erection for anything. I started watching the television
and I started to have a warm feeling in my stomach from watching my favorite show. I
started to get all these feelings from my body that I never get. I started to get
cold chills from watching a movie. I started to have hunger pains. I never feel
hungry. I walked outside. The breeze felt so good that day. When I went to work. I
looked at people in the face and spoke to them without feeling frozen with anxiety.
The next day I woke up and took the next dose of Jdtic at 10am. I woke up and had
breakfast. I started to watch television. I couldn't stop laughing. I was in a great
mood. I was laughing, talking to the television. I was talking and joking with my
friends through text messages. I went out for lunch with with my only close friend
left. I kept making her laugh. It was wonderful. I've spent my whole adult life not
being able to touch anyone emotionally. Now I can make people laugh. I started to
see the punch line. I started to become really funny. That day at work. I started to
have these really brief, weak emotions. They were really weak and confusing. But I
was really happy to have them. I started to feel touched by music. I felt driven to
sing along with the music. That day I also caught myself looking at a women's
breast. I started to want to look at her body. I never do that. I usually do not
even notice women anymore. My memory also improved. I usually can't remember any of
the streets. That day I remembered all of them and thought of a plan of the best way to
get there, instead of using a gps.
The next week I planned days out with all my old friends. I wanted to be warm and
try to make them feel loved, and make them laugh. I was trying to make up for being
a cold emotionless person to them. I also went to spend time with my grandfather. My
grandfather is dying. I was too messed to go and see him. I tried my best to be warm
and affectionate to him.
The last few days of the trial. I started to have moments where I felt like my life
had a sense of urgency. I felt like I had to do things. I felt like I had to go home
and read my science books. I'm not sure if I would call it motivation. I just had
these moments where I really wanted to find my vocation in life. I was going to
college for chemical engeneering before I got sick. I just kept having this urgent
feeling that I wanted to finish.
JDTic was very helpful. I still had problems, but I was slowly starting to feel
better. I'm not sure what would happen if I continued to take it. I would love to
find out. I hope that I was helpful. I'm a little tired. I hope I remembered
everything
Swimmingdancer
Bluelight Crew
Wow, that sounds very effective
Did you experience any side effects? Do you know if this drug has the potential to cause a physiological dependence?
Did you experience any side effects? Do you know if this drug has the potential to cause a physiological dependence?
RobotRipping
Bluelighter
that is an extremely interesting report. I would definitely love to hear more about this compound and perhaps try it some day.
phatass
Bluelighter
yeah, i'm a bit sceptical, the dude who posed this glowing report only has 3 posts, and if i had similar issues, depression, anxiety etc, which loads of people have, after reading that report i would probably buy soe.... so, publicity stunt? just wondering
Swimmingdancer
Bluelight Crew
Yeah, that's a really good point. The person who started this thread has the username "jdtic" and their only posts have been in this thread, and the person who posted that totally positive trip report has only posted in this thread as well. Hmm.... 8)
Also, one thing I find strange about JDTic and it's purported potential uses/effects is that it is a κ-Opioid antagonist. κ-Opioid agonists are known to have therapeutic potential in the treatment of addictions, depression and other mental health issues. One would assume that an antagonist would actually have the opposite effects, in fact dosing rats with a κ-opioid antagonist markedly increased their alcohol consumption. I guess there is still a lot to learn about how these receptors affect us, but I definitely do not know enough about JDTic yet to want to try it, nor does it appear to be readily obtainable.
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