Immunity to LSD?

[louisvillemusicman]

I've opened a thread about this before, but I have to ask again because of recent events. Ever since last summer I feel like I have had some sort of immunity or mental tolerance to LSD. My friends can take 2 hits and I'll take 3 and they'll be tripping way harder than me. Is there any reason for this?
I recently got some hits that were 100mcg each and when my friends took 1 hit, they had a blast! I took 3.5 and it really didn't wow me much. We have all tripped around the same number of times (less than 15) and so I don't understand how I am tripping much less harder than them. I told them I took 3.5 and they said they would have never done that because it would have been way too high but 3.5 wasn't enough.
I plan on taking 6 next time because I'm not getting what I feel like I should be getting out of this. The first few times I tripped, I feel like I was on the same level as my friends but now they're way above me. The first time I tripped on this batch with 1 hit was about 3 weeks ago and that was my first time in 4 months. The second was about a week and a half later with the 3.5
Does anyone know reason behind this or anything I could do to make me trip harder?
Thanks a bunch
Love & Peace,
Ben

 

[cryptix420]

First, I wouldn't put too much weight into how many ug's someone tells you a blotter has on it. Most blotters average at around 50-80ug per tab. Some people do have an inherent higher tolerance to psychedelics, while some are the opposite (usually females). There can also be variances between tabs on a sheet if it was not layed properly. There is also the issue of tolerance, LSD takes 2 weeks-1 months to really lower your tolerance, while you will need to wait even longer for the true 'magic' of the experience to return. You need to allow yourself time to integrate the experience into your life (not that I always follow this rule either...having a large stash of psychedelics is tempting sometimes).

 

[Happy Trails]

Are you currently using any prescription medication?

 

[louisvillemusicman]

Yes, I take 300mg of Wellbutrin and 50mg of Vyvanse daily that I've been taking since before I ever tried LSD. I didn't have an inherent tolerance when I first started, just these past few times. The only thing I can think is if the sheet was laid wrong but I won't ever know that. Since last July I have tripped on three different batches and it seems to be the same story each time. I have a lot of fun but I feel like it would take a much larger amount than I have taken before to reach the same level

 

[Jesusgreen]

Wellbutrin and Vyvanse shouldn't affect your trip at all other than likely boosting the stimulating side of the experience. So your medication isn't the culprit here.

You say you've only tripped 15 times, but how often do you trip? Also does that 15 times include other psychedelics or did you not count any other trips you may have had?

 

[louisvillemusicman]

That is about 15 times doing acid. I've tried shrooms once and DMT once but I didn't blast off (the dosage was too low)
I started in November 2010 and from November 2010-February 2011 I tripped 10 times. Then twice in July, once in December, and twice in April.

 

[Flickering]

Weird. You shouldn't have developed such strong tolerance to it doing it only around once a month.

Perhaps you and your friends are getting bunk acid. But your friends, believing it to be genuine, feel the effects powerfully, i.e. placebo effect, whereas you are less susceptible to suggestion. After all, these tabs come from a new batch, right?

Perhaps you've simply been unlucky, and taken taps from a side of the sheet with only a shallow exposure to LSD, whereas your friends took tabs from the 'deep end'.

Maybe you're following the tabs down with water, which, according to Shulgin, can destroy a significant portion of the substance (if it's not distilled, I think?).

Or maybe this is simply a very unusual case of spontaneous mental resistance to the substance, which has to happen sometimes I suppose.

But this is all speculation. The human mind is a mystery, and a mystery a hundredfold when combined with psychedelics.

 

[Aetherius Rimor]

Wellbutrin and Vyvanse shouldn't affect your trip at all other than likely boosting the stimulating side of the experience. So your medication isn't the culprit here.

Wellbutrin may have some effects, but I doubt it'd be as strong as he's describing.

According to drugbank.ca Bupropion is a "Neuronal acetylcholine receptor subunit alpha-3" antagonist. Not entirely sure exactly what type of effect that might on the trip, but I know there are studies done that acetylcholine promoters do potentiate a trip. It's anticholinergic property could be dampening some effects, seeing as a few anti-psychotics antagonize acetylcholine receptors (as well as dopamine and 5HT2 series).

There is also the issue of tolerance, LSD takes 2 weeks-1 months to really lower your tolerance

According to what? Everything I've read so far has said tolerance to tryptamines (and LSD) usually dissipates completely in 2 to 3 days. I did a search for 5HT2A downregulation reversal, but only research paper I found was in reference to phenylethylamines, and was speaking about DMT (a tryptamine) having a very quick tolerance loss and it being unique for it. That is from "Differential Tolerance to Biological and Subjective Effects of Four Closely Spaced Doses of N,N-Dimethyltryptamine in Humans", BIOL PSYCHIATRY 1996;39:784--795, a study Strassman was involved in.

I've done two "re-doses" when on LSD before and the redose worked as intended. Presumably not as strong as they would have been on their own, but definitely amplified the current experience.

 

[Dimitri K.]

Wellbutrin and Vyvanse shouldn't affect your trip at all other than likely boosting the stimulating side of the experience. So your medication isn't the culprit here.

Unless we have other people here have done this combo and can report this, I don't think we have any way of knowing how things will interact. The tryptamines are such mysteries. Anyways, prescription drugs always have fillers.

 

[bluedolphin]

I know of one person who can take very high doses of LSD and be hardly affected at all by it.

From what I gather, this is a particularly rare condition, but I suppose you could be like my friend who is somewhat "immune to LSD" as well.

 

[Jesusgreen]

Unless we have other people here have done this combo and can report this, I don't think we have any way of knowing how things will interact. The tryptamines are such mysteries. Anyways, prescription drugs always have fillers.

I'm actually basing this on several people I know's experiences. As for regarding negative reactions, check out: http://www.bluelight.ru/vb/threads/...-Recreational-Drugs-(long!)?s=&postid=1995503

Of course combining these will result in changes in the experience, but what I'm trying to say is that it should not cause a significant reduction of effects or any real problems like for example SSRIs may.