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  • BDD Moderators: Keif’ Richards

Oxycodone + Dip = Always Puke, why?

whippa craka

whippa craka

Bluelighter
Joined
Jan 11, 2011
Messages
571
Location
Buffalo, NY
I have a fair amount of experience with oxycodone and also a good amount with packing lips (tobacco). I pack multiple lips a day and rarely feel a headrush. Whenever I dose on any kind of oxycodone, wether snorting 30mg or eating 40-80mg OP whenever I pack a lip, I always puke. Now here is the weird thing:

I can pack my lip fine for about 20-30 minutes and then I would take it out. About 20-30 minutes after that I will start to feel a little queasy and then I will start salivating like crazy. My mouth is literally a running faucet. Soon after, within 1-2 minutes while still salivating I will puke. I won't "hurl" or anything like that, I just vomit a small amount and then I feel fine. This has happened EVERY time I do this combination. I see my friends do this all the time w/o an issue and I have never seen somebody have an issue like this. It is not even necessarily a nausea issue, this wave of salivation and then quickly puking just seems to hit me for 1-5 minutes around 30 minutes after I take my lip out.

There has been a couple times where If I am able to put my head down in darkness and just relax as much as I can it will pass. All the while salivating like crazy. I am stupid enough to keep experimenting with this because I am trying to see with tolerance if this issue will go away, but it just wont!

Opinions anybody? Thanks.
 
Opiates can cause vomiting, so can chewing tobacco. Sometimes I get nauseous after smoking cigarrettes on opiates. Might have to do with dopamine which controls vomiting.
 
Its just that you haven't developed a nicotine tolerance yet. A nicotine overdose excites your cholinergic nerves, which causes the salivation, sweating and nausea. Large amounts of nicotine also block the neuromuscular junction, causing a feeling of lack of power in your muscles and a need to lie down motionless.

In high school I used chewing tobacco before I started smoking cigarettes, and I often got the same symptoms when I took too much.
 
polymath said:
Its just that you haven't developed a nicotine tolerance yet. A nicotine overdose excites your cholinergic nerves, which causes the salivation, sweating and nausea. Large amounts of nicotine also block the neuromuscular junction, causing a feeling of lack of power in your muscles and a need to lie down motionless.

In high school I used chewing tobacco before I started smoking cigarettes, and I often got the same symptoms when I took too much.
Click to expand...
I seem to disagree. This is an issue unique to opiates.

I have a habit most likely equivalent to at least a pack a day. It's getting kind of ridiculous actually. I can throw a chaw in the size of half a tin and feel mildly relaxed if anything at all - head rushes are long forgotten. Never once have I had an issue puking from tobacco, or opiates; only with the two combined. I do have red hair if this may happen to be related to anything http://en.wikipedia.org/wiki/Red_hair#Medical_implications_of_the_red_hair_gene
 
Nicotine inhibits many of the same enzymes responsible for metabolizing opiates, making your dose functionally stronger.

There was a thread similar to this in od not long ago, and another poster thought nicotine was also a weak mao-I, making the opiate functionally stronger as well, but I don't know about that. Might check on it.
 
If I may add - Regardless of the dose of nicotine. (Again, I have no issue with nicotine by itself at any point throughout my life), after my cigarettes or dip session the opiate buzz seems to 'die'. In otherwords, any nod or euphoria I was getting from the oxy seems to be diminished almost completely. I am put in more of a hazed state of mind then the oh so familiar and enjoyable opiate buzz state of mind.

I know something is going on that isn't quite normal. I have had friends with similar opiate tolerance be on the same dose as me and then throw a chaw in for the first time and they do not experience these negative sides like I seem to.
 
Eek, I'm not a pharmacologist or anything but I would like to contribute my theories regardless.

Theory on reduction of 'nod':

Well, with nicotine administration, you're getting more acetylcholine (ACHR) release via nicotinic acetylcholine receptors being activated. Well, this can definitely effect a 'nod'. It's definitely giving you locomotor stimulation which may release you from a 'nod' state. Locomotor stimulation by oxycodone via activity with the mesolimbic dopamine (DA) system have affect with behavioral sensitizations induced by nicotine at the a1b-adrenergic receptor; thus, nicotine will decrease the opiate's reward by blockade of these receptors and produce a decreased response with concomitant nicotine use.

Look at nicotine's effects on dreaming and other cognitive processes... it's pretty advanced and I think it's because of ACHR activity induced by nicotine.

Theory on nausea:

Basically, a 'double whammy' of nausea from oxycodone and nicotine.
 
Last edited:
THC2LSD said:
Opiates can cause vomiting, so can chewing tobacco. Sometimes I get nauseous after smoking cigarrettes on opiates. Might have to do with dopamine which controls vomiting.
Click to expand...

This exact thing happened to me last night. Won't be smoking on opiates again.
 
@Tigers

Everything seems right... except for the nod part. If anything from that point forward I am more awake. I don't nod, and they're all in fairly small doses.
 
Everything seems right... except for the nod part. If anything from that point forward I am more awake. I don't nod, and they're all in fairly small doses.
Click to expand...

Read it again; that's what I'm saying.. increased ACHE release by a nicotinic receptor agonist should make you feel more alert bro. That was the the point of all of that I typed.........
 
@Whippa Craka
Do you experience any other negative effects from dipping whilst on opiates? I have only combined dip with opiates a few time (I usually smoke a lot of cigarettes on opiates and am just fine when I do) and I began to sweat a lot and get nauseous. I'm basically wondering if you get the sweat with the combination as well.

Geaux Tigers! said:
Eek, I'm not a pharmacologist or anything but I would like to contribute my theories regardless.

Theory on reduction of 'nod':

Well, with nicotine administration, you're getting more acetylcholine (ACHR) release via nicotinic acetylcholine receptors being activated. Well, this can definitely effect a 'nod'. It's definitely giving you locomotor stimulation which may release you from a 'nod' state. Locomotor stimulation by oxycodone via activity with the mesolimbic dopamine (DA) system have affect with behavioral sensitizations induced by nicotine at the a1b-adrenergic receptor; thus, nicotine will decrease the opiate's reward by blockade of these receptors and produce a decreased response with concomitant nicotine use.

Look at nicotine's effects on dreaming and other cognitive processes... it's pretty advanced and I think it's because of ACHR activity induced by nicotine.

Theory on nausea:

Basically, a 'double whammy' of nausea from oxycodone and nicotine.
Click to expand...

I think that most people nod more when combining tobacco with opiates. I know that I do, and I actually will buy less of whatever opiate I am getting so that I can buy a pack of cigarettes to smoke while high since 80 of oxycodone + no cigarettes does not get me as high as 60mg of oxycodone + cigarettes. If my nod is wearing off I can smoke a cigarette and it will kick back in.
 
This is kinda gross, but Could you be swallowing some/more of your tobacco-laced saliva due to the opiate? I'm opiate naive and the few times i took a perc, or enough of a roxi to be super-relaxed/almost nodding and smoked a cigarette i noticed i was really likely to swallow some of the smoke by accident which would lead to super-salivating and almost puking.
 
@Tommy

Thank you for the input. I would say I have very similar symptoms. Here's how I would put it. This is all in terms of the opiates being in full effect in the body. I never have issues if I have nicotine when I first dose on the opiate or when it starts to wear off (6+ hours later)

Small dose nicotine:
  1. More alert
  2. nod is reduced
  3. Itchiness moderately reduced
  4. Usually can avoid any nausea
  5. The opiate high is different from this point forward - it seems to diminish


High dose nicotine:
  1. Nod is removed
  2. Itchiness is greatly reduced
  3. No more "eye-wiggles", can focus on everything more easily
  4. Sometimes experience a very warm feeling - sometimes will sweat.
  5. At +00:45 after first packing the lip (usually 10 minutes after removing it) I will have all the above symptoms and then start salivating and the wave of nausea starts
  6. The wave of nausea is <2 minutes long. I will salivate and salivate and salivate and eventually puke a small amount and then feel fine and then continue to just feel more alert and the effects of the opiates diminished. The wave of salivation will last about 2 minutes, and if it passes I will not puke. The only way I can get the wave to pass is if I close my eyes and put my head down in darkness and focus on relaxing.

I just found it weird how much I would salivate and randomly puke. For that instance I feel nauseous, but otherwise I do not. These explanations have been helpful, thanks all. Second anybody?
 
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