confused about bioavailability & dosing

[Anon54]

Say im shooting heroin & the BA if 100% & the BA for snorting is 50% just as an example.
Does that mean that snorting twice as much heroin will give me the same rush as shooting it without the quicker onset of course?

Or doesnt it work that way. what if I snorted 3x as much. Would that give me the same rush without the quicker onset ofcourse than shooting?

In thoery it should have the same effect. shouldnt it?

 

[SPC123]

You are sort of correct. If BA is 100% IV, 50% nasally, you'd need twice as much drug nasally to achieve the same blood serum levels. However the "rush" or rate of absorption differs by ROA, and will not change based on the amount you take (in a linear fashion). That is to say, snorting twice as much drug is going to cause that drug to hit a bit faster and a lot harder, but nowhere near as fast or hard as IV, regardless of BA%. For example, oxycodone. The BA% is about 90% oral, 50% nasal, however the nasal ROA will hit faster than oral.

 

[madog11]

Your first comment is right. You would need double to get as high as shooting. If you snorted 3 times as much then it would get you higher without the rush of IV.

 

[effie]

The effect of the drug depends on both the blood concentration achieved and the rate you achieve it. Insufflating twice as much of something with 50% nasal bioavailability will give you the same blood concentration, but achieved over a longer period of time, so you are less likely to get the initial rush. When you say "the same rush without the quicker onset" - the rush is generally all about hitting a high blood concentration in a short space of time so while you will end up with the same amount of drug in your bloodstream, it won't necessarily feel the same.

Having said that, obviously the risks of IV are far greater than insufflated, so if you are after a safer way to get a high insufflating twice as much of something with a 50% nasal bioavailability is definitely worth the trade off IMO.

 

[likeakite]

Nothing compares to direct injection.

 

[effie]

Maybe so, but the risk is much, much higher. Need to carefully weigh up if it is worth it or not. The vast majority of people who IV really regret ever trying it..

IV complications megathread..

We're getting tough on people advocating IV use to those not asking about it - you weren't doing that in this thread but thought I'd give you a heads up, as it is an instant warning/infraction now - flies against HR. Stating facts if asked about IV use is obviously okay though, we don't censor shit like that here!

 

[SPC123]

I have never IV'd (outside a hospital/clinical setting) and I never would. Put it this way: I hear erotic asphyxiation is supposed to be way better than normal masturbation, but considering the risks, I'll beat it like it owes me money before I put a belt around my neck.

 

[THC2LSD]

Snorted feels more like IM/SC than IV. With IV you get the rush from the diamorphine which quickly breaks down into monoacetylmorphine after a few minutes. Diamorphine has almost no protein binding so it hits harder.

 

[ErgicMergic]

Nothing compares to direct injection.

The greater the high, the greater the addiction.

To all the drug users out there reading this, don't ever pick up the needle. It makes it easier to walk away from drugs when you want to get to clean, and that time will come, a year from now or ten years from now.