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Opioids Ginger extract prevent opioid tolerance/WD ?

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Deleted member 170540

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I've never used opiates myself, but this study looked so unbelievable that I had to post it... This was published by some Iranian researchers early this year.

Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats

Abstract

Ethnopharmacological relevance
Ginger (Zingiber officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments such as opiates withdrawal-induced disorders. However, its influences on opioid tolerance and dependence have not yet been clarified.

Materials and methods
Adult male Wistar rats were rendered tolerant to analgesic effect of morphine by injection of morphine (10 mg/kg, i.p.) twice daily for 8 days. To develop morphine dependence, rats given escalating doses of chronic morphine. To determine the effect of ginger on the development of morphine tolerance and dependence, different doses of ginger were administrated before morphine. The tail-flick and naloxone precipitation tests were used to assess the degree of tolerance and dependence, respectively.

Results
Our results showed that chronic morphine-injected rats displayed tolerance to the analgesic effect of morphine as well as morphine dependence. Ginger (50 and 100 mg/kg) completely prevented the development of morphine tolerance. In addition, concomitant treatment of morphine with 100 and 150 mg/kg attenuated almost all of the naloxone-induced withdrawal sings which include weight lose, abdominal contraction, diarrhea, petosis, teeth chattering, and jumping. In addition, morphine-induced L-type calcium channel over-expression in spinal cord was reversed by 100 mg/kg ginger.

Conclusion
The data indicate that ginger extract has a potential anti-tolerant/anti-dependence property against chronic usage of morphine.
Click to expand...

Has anyone heard of people using ginger extract for this purpose? Does anyone really believe it can be that effective?

EDIT: the source is http://www.sciencedirect.com/science/article/pii/S0378874112001900
 
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This is pretty interesting to me, but I'm not good at science speak:) How would be the best way to test this? I can currently take 100mg of Morphine orally to kill pain and feel that muscle relaxing feeling, but nowhere close to nodding. In fact, I've never nodded, I use it mostly for the pain relief and the relaxation it brings. Will it bring down my tolerance? Or just keep it at that level? Should I take the ginger, start out with like 30mg, and up it from there? Some discussion on this would be awesome, would love to read everyone's ideas and input:)
 
ive heard that ginger helps with nausea but this shit is wild if its true.. ima have to try this being that im in the perfect state to try it.. my RLS right now is making me want to kick somebody in the face lol
 
Those calcium channels are also involved in alcohol tolerance and WD... Next time I get drunk I'm gonna take a couple teaspoons of ginger with the booze and see if it prevents the hangover next morning.
 
It's also been observed that ginger protects the liver from toxins like acetaminophen or alcohol...

One suspicious feature of these studies, though, is that they've all been made in third-world countries... The poor researchers there could be faking positive results to get more funding for their work. :|
 
100 mg/kg of extract is a lot, and given that nobody has found the active component, I would be suspicious too...

I do know that in cases like this where some mystery miracle drug "prevents tolerance development", one of the folloing inevitably turns out to be true:
1. Studies are not reproducible
2. Active dose of the compound is ridiculous
3. The studies never pan out to humans.

Sure, if you want to eat a pound of ginger root daily... the relevant bits from the paper on prep'n of the extract are below.

A total of 1 kg of fresh ginger was purchased from the main
vegetable market in Khoramabad. A sample of the rhizome was
deposited at the herbarium of the Razi Herbal Medicines Research
Center, Lorestan. Two hundred grams of the air-dried rhizome of
the herb was ground into fine powder. The powder was extracted
twice, on each occasion with 1 l of 80% ethyl alcohol. The ethanol
extract was filtered, and the filtrate was concentrated until dry
under reduced pressure in a rotary evaporator and the resulting
ethanol extract was freeze-dried.
Click to expand...

I expect you will need a lot of ginger, the typical human is much heavier than a Wistar rat.
 
Hmmmmm...I love fresh ginger I eat it all the time (usually minced into food (alot) My prescribed oxycodone is still a number 1 pain killer, even taken w/ small amount of buprenorphine. I'll take it thank you very much
 
My personal thoughts on this whole subject, is if there was a drug that truly prevented development of morphine tolerance/withdrawals, why on earth is it not, at the very least, all over the medical journals and widely accepted by multiple peer-reviewed studies?

Moreover why is it not in widespread use in humans, if it's so effective? Stopping the development of drug tolerance is one of the Holy Grail problems of pharmacology. At the very least you'd see it marketed, and used, in chronic pain centres/hospitals.
 
The dose they're referring to is really really large.. and honestly it's entirely possible for nobody to have noticed up until now.

Ginger is an excellent anti-nausea treatment, more effective than most.. I'd be inclined to believe it's possible, I'll take notes if I get around to trying it out... The dose does put me off somewhat though, we're talking like 5-10g for my bodyweight.
 
There are a lot of questions that need to be answered to practically address this.

It is vastly important to know if that's 100mg/kg root or extract. I have a bad feeling it's extract - this would indicate that we'd be using heaps of ginger root, and any time you're taking heaping quantities of something with biological activity, that raises the risk of side effects. Sure ginger is safe, but do people eat it in the quantity equivalent to 100mg/kg of extract daily on a long-term basis?

Also - we don't know what the active chemical is. So we don't know what process is needed to extract it. Does it come through in tea? No way to know.

Anyone with the full text checked how they administered the ginger? Was it orally? If it was injected, we face another issue in adapting this to humans; shooting up plant extracts is a Bad Idea, so we'd be facing an unknown oral bioavailability, and the possibility that first-pass metabolism will chew up all the active god-knows-what before it can work it's magic.

pontifex01 said:
same as what MeDieVil did with DXM for opiate tolerance and WD.
Click to expand...

Where is this thread? Did it work?
 
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