If one is switching from oxymorphone to methadone how does one account for the greatly different half-life's of oxymorphone vs. methadone?
On the conversion chart I looked at it says that 300mg oral oxymorphone per 24 hrs. is equivalent to 60mg methadone "chronic dosing".
But I am wondering if one really needs that much methadone due to the fact that a single dose of methadone lasts so much longer than a single dose of oxymorphone.
If one dose of oxymorphone lasts about 4 hours and you take about 5 doses per day, and one dose of methadone lasts about 24 hours, should you convert your sum total of daily oxymorphone doses?
Or should you just convert one dose of oxymorphone that lasts 4 hours into one dose of methadone that will last 24 hours?
On the conversion chart I looked at it says that 300mg oral oxymorphone per 24 hrs. is equivalent to 60mg methadone "chronic dosing".
But I am wondering if one really needs that much methadone due to the fact that a single dose of methadone lasts so much longer than a single dose of oxymorphone.
If one dose of oxymorphone lasts about 4 hours and you take about 5 doses per day, and one dose of methadone lasts about 24 hours, should you convert your sum total of daily oxymorphone doses?
Or should you just convert one dose of oxymorphone that lasts 4 hours into one dose of methadone that will last 24 hours?