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lsd and mescaline

But if they are all alkaloids then why would they all magically vanish but the mescaline?
 
They have different substitution patterns (be it on the phenyl ring or on the nitrogen) and therefore have different properties like solubility in a solvent. With an adequate solvent a big portion of non-mescaline alkaloids go in solution and leave mescaline back as a solid. Repeating this process a few times and followed by of another suitable solvent further increases the purity (although it will never reach 100 % ).

An a related note: a simple procedure to retrieve residual mescaline out of the "other alkaloid"-fraction could be nice after a few extractions.

Sorry for being offtopic.
 
Is the experience qualitatively different with or without the other alkaloids..? Is there a benefit to one doing the isolation of straight mescaline, or are the other alkaloids catalytic/supportive-to the psychedelic experience...? Also curiou is the psychoctivity by weight is noticably effected by isolating only mescaline....is there a significantly-weighing amount of non-mescaline-alkaloids in the extract before washing the extra time for isolation?
 
sn23 said:
They have different substitution patterns (be it on the phenyl ring or on the nitrogen) and therefore have different properties like solubility in a solvent. With an adequate solvent a big portion of non-mescaline alkaloids go in solution and leave mescaline back as a solid. Repeating this process a few times and followed by of another suitable solvent further increases the purity (although it will never reach 100 % ).
.
Click to expand...

What step are you talking about? You've just crystallised from the base and got mescaline and all the other alkaloids. What solvent do you think will now remove every alkaloid but mescaline?

And how many people do you think go to the effort of doing furthur extractions when they've already got something that is largely mescaline with the additional alkloids anyway?
 
thoughtsUnThought said:
Is the experience qualitatively different with or without the other alkaloids..? Is there a benefit to one doing the isolation of straight mescaline, or are the other alkaloids catalytic/supportive-to the psychedelic experience...?
Click to expand...

With san pedro it's neglible - there's only 6 or 7 other alkaloids. With peyote there's close to 70 so that might have more of a noticeable effect.
 
Ismene said:
What step are you talking about? You've just crystallised from the base and got mescaline and all the other alkaloids. What solvent do you think will now remove every alkaloid but mescaline?

And how many people do you think go to the effort of doing furthur extractions when they've already got something that is largely mescaline with the additional alkloids anyway?
Click to expand...

Who cares what "other" people do, they're talking about what they do, which you found fit to attack. There are plenty of ways to isolate certain alkaloids in full spectrum extracts, go ask in advanced drug discussion if you're insistent on being stubborn about it.
 
thoughtsUnThought said:
Is the experience qualitatively different with or without the other alkaloids..? Is there a benefit to one doing the isolation of straight mescaline, or are the other alkaloids catalytic/supportive-to the psychedelic experience...?
Click to expand...

There’s an alkaloid in San Pedro that makes me really speedy, almost a different experience from T. Bridgesii which gives me only a slight increase in heart rate and gives almost a calm feeling. Peruvian Torch has a little ‘floaty’ feel to it, almost like I’ve taken some hydrocodone with the trip, but these are just my reactions to the various alkaloids.


Ismene said:
What step are you talking about? You've just crystallised from the base and got mescaline and all the other alkaloids. What solvent do you think will now remove every alkaloid but mescaline?
Click to expand...

Isopropanol can remove alkaloids that acetone will not.


Ismene said:
And how many people do you think go to the effort of doing furthur extractions when they've already got something that is largely mescaline with the additional alkloids anyway?
Click to expand...

I’ve taken up to 1.2g of semi-purified mescaline only washed with acetone and reached only a ++, while other times I’ve taken 500 mg of the semi-pure mescaline (from a different extraction) to reach that state. In my experience a final recrystallization or wash can make a big difference in the final product. I think cactus varies widely with the amount of alkaloids (or other junk in your extraction) so it’s tough to tell whether light brown extract is mostly mescaline or mostly alkaloids.
 
Ethyl_Acetate said:
Isopropanol can remove alkaloids that acetone will not.
Click to expand...

But does it remove the alkaloids from extracted cactus? Every extraction guide I've ever read says you end up with all the alkaoids. I've never seen a step that says "This will remove all the other alkaloids".

In my experience a final recrystallization or wash can make a big difference in the final product.

Does a wash really remove all other alkaloids?
 
IamMe90 said:
Who cares what "other" people do
Click to expand...

In other words you have absolutely no idea how you extract all the alkaloids from cactus and just wanted to make a post attacking me because I disagreed with 6 months ago and you're still festering about it. Get over it. Move on.
 
This combo has me extremely interested. In a few weeks or so I'll try about 300mg mescaline with 320ug acid and write a TR on it.
 
I have wondered this as well for some time. I tried san pedro and mdma. The mdma was taken well into the experience ( 6 or 8 hours or so,) and I had some LSD with full intentions of taking that at the same time as the mdma, but didn't. The mdma did not add much to the experience at all; it seemed to sober me up a little almost, with a slight rolling feeling. I never bothered with the LSD. I came to the realization that mescaline is perfect on its own. Why bother adulterating it? It has such a full, well rounded, gentle experience there is nothing that could make it better to me. I really like all three of these things, even candy flipping, but I feel mescaline is just too gd perfect, and shouldn't be combined with anything.
Just to show you how strongly I feel about this, I haven't posted here since I signed up, but this topic made me want to voice my words. And it was a ISO extraction from dried powder, for the cactus that time, and it was fairly strong dose. Two other parties with me agreed, and one was in a ++++. MDMA dosage was around 130mg then 80mg (forget what I weighed out)
 
I don't do combos ever really, but when I ate mushrooms on top of a Peruvian torch tea I was blown away. Very insightful and ancient feeling combo.
 
Ethyl_Acetate said:
There’s an alkaloid in San Pedro that makes me really speedy, almost a different experience from T. Bridgesii which gives me only a slight increase in heart rate and gives almost a calm feeling. Peruvian Torch has a little ‘floaty’ feel to it, almost like I’ve taken some hydrocodone with the trip, but these are just my reactions to the various alkaloids.
Click to expand...

That might just have been your imagination ethyl. Mescaline is by far the biggest alklaloid content and there are only 6 or 7 other alklaloids in san pedro. Putting them alongside a powerful psychoactive like mescaline you'd be very hard pressed to feel them, even if any of them are psychoactive.

Peyote with 60 odd alkaloids is more likely to give you a different feeling.
 
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