Venlafaxine (effexor) + Dxm ?

[Psylex]

Hey all, so i have already been through the "AD+drugs" FAQ and it says that combining Venlafaxine + Dxm is potentially dangerous because both are metabolised by the same enzyme... does this only mean not to ingest both substances at the same time ?

Ex, "The Routine" : 75 to 140 mgs max venlafaxine 5-6 hours before taking 400 to 600 mgs dxm plus (obviously) two big ass joints during the robbotrip

These days i'm a lot into Dxm and i can't resist the urge of tripping once a week, which is quite often for someone who might get bad interactions...

Also, what are REALLY the odds of a serotonine syndrome with the dosages above?

- I've already tried venlafaxine and weed on many occasions (only on 75 mgs effexor though) and, while some people have reported problems (heart), it's all fine for me.... maybe on higher venlafaxine dosages there might still be a problem?
- A few days ago i did for the first time that "routine" and it went very well ( between 2nd and 3rd plateau trip : euphoria and dissociative effects)

By the way i LOVE that special euphoria you get when you smoke a blunt on the first peak of a 2nd plateau... it could (slightly) replace rolling during a break from molly.

Uugh, i can't wait to get off Venlafaxine to be able to experiment in freedom again.

 

[YellowPolkaDotHalo]

When I was on paxil I found it combined really well with dxm compared to when I robo'd when not on it. Seemed to get just the right level of serotonin for me at the time perhaps.

Venlafaxin is a whole different kettle of fish though.. and dxm combos really havnt been studied in any depth..

Totally understand you doing it anyway.. but youre flying without a net there.. Vunerable to SS or Messiahic complexes.

But if youre into either walking funny allla SS or wearing sandals round the local looney bin go for it.

Be safe!

 

[Psylex]

Haha cheers for your feedback. Dxm in itself isn't only about insanity (actually in comparison with deliriants, dissociatives could look quite sane lol). I'd say it's either about the euphoria (2nd plt) or about exploring your fucking weird subconscious (3rd plateau), aaand... i don't have the balls to yet go to the 4th plateau, which is what put off all my mates a year ago, leaving me as the only robbotripper there hah. I'd rather try out K-holing first than Dxm 4th plt.

Is there anyone out there who can tell what i risk if next time i throw :
Approx: 100 mg venlafaxin (morning) + (late arvo) 500 mgs Dxm (7 mg/kg) + ganja (thc slighlty affects serotonin right? already it does raise the heart rate)

I think i'm gonna have to ask my doc on this one X)

Because the thing is last time it worked fine but now i gotta increase the effexor and wanna raise the dxm a bit higher... perhaps i just need to take a low venlafaxine dose that day..

 

[SPC123]

I have done 600mg DXM while on 150mg Effexor with no issue, however your results might differ. I would suggest waiting for a couple of weeks after you bump up the Effexor dose to give your body time to adjust.

 

[effie]

DXM and venlafaxine is not a safe combination. DXM releases serotonin and venlafaxine is a serotonin (and norepinephrine) reuptake inhibitor, meaning your brain can be flooded with serotonin which isn't reabsorbed, potentially causing serotonin syndrome which can kill you.

Interactions checker showing major interaction between the two
Serotonin syndrome

Please don't take this combination, especially if you are increasing the doses - just because you or someone else were okay before doesn't mean you will be again!

 

[BabyGurl3171]

DXM and venlafaxine is not a safe combination. DXM releases serotonin and venlafaxine is a serotonin (and norepinephrine) reuptake inhibitor, meaning your brain can be flooded with serotonin which isn't reabsorbed, potentially causing serotonin syndrome which can kill you.

Interactions checker showing major interaction between the two
Serotonin syndrome

Please don't take this combination, especially if you are increasing the doses - just because you or someone else were okay before doesn't mean you will be again!

^^^ This.
Plus I wanted to say...holy shit, that's a lot of DXM! No wonder the one time I tried it I had no reaction. I think I did like 250-300 mgs.

 

[Pjkt2501]

^ It's actually not a lot of DXM if used by itself. 300mg is enough for threshold effects, if even. My one and only DXM-experience was with approximately 780mg (which was fairly intense, but nowhere near 500ug of LSD for instance).

OP: As effie has stated - you're risking your life for a very lame high (in my opinion on the lameness, not opinion as to the risk of life). Ketamine doesn't have the same serotonin selectivity and is indescribably better and more interesting as a compound to experiment with.

 

[Psylex]

Yeah i might back off this one :/

-On the "lameness" : As a semi-frequent high (3, 4 times a month, and only these days because i'll move on to other stuff when i can) i find Dxm+Ganja to be quite comfortable and safe (without effexor) ... it's "lame" in comparison to K, lsd, dmt, mdma... but they would be far less suited for a semi-chronic use / experimental routine (a robbotrip every weekend is less exhausting than rolling or dropping acid too often).... hmm but that could be quite debatable, i think i should move to ketamine because it's safe with venlafaxine.

Thanks for your answers, but i was wondering : instead of upping both dosages, if i keep up with exactly the same dosage as last week (75 mg effexor, 400 mg dxm + thc) i should be fine for one last time since it went well last time no? I don't get why with the same dosages, one day i'm fine and the other day i could have a serotonin syndrome..
(This would be the day before i have to go 150 mg effexor)

Ps: i never managed to go very far with acid yet but if 500ugs beats a big dxm 3rd plateau in intensity, i'm interested lol

 

[Pjkt2501]

"lameness" is subjective. 100% user-based. What works for me may not work for you.

I will say that NMDA-agonists are much worse for you long-term than LSD is, by a long shot. Unless you're mentally unstable to begin with, then either of 'em is gonna turn ya south. I've effectively eaten LSD every weekend (or more often) for a year-2 straight, and I personally feel more in touch with my life and my goals than ever.

MDMA on the other hand... Miss Molly has left her toll on me, no questions. My memory isn't too good (however it never was), and my math skills have deteriorated.

I would personally cease using DXM. Honestly on any SSRI / SNRI you can't safely take LSD, MDMA, or anything with serotonergic properties.

 

[effie]

I would personally cease using DXM. Honestly on any SSRI / SNRI you can't safely take LSD, MDMA, or anything with serotonergic properties.

This. Honestly, it is not worth risking having a fatal reaction.

As I said elsewhere, combining two serotonin reuptake inhibitors isn't too bad (but still not advised) but combining a releaser (DXM) and a reuptake inhibitor (venlafaxine) really is asking for trouble.

 

[laCster]

agreed wih all the other posters, DXM with other SSRI's/SNRI's is just not the risk. IMO DXM was one of the best legal A/D's i've ever tried, but i am a little biased lol. if i were you, i would cut out on the effexor all-together, and take 60mgs-90mgs DXM daily instead.

but again, definitely do NOT mix the two

 

[Pjkt2501]

agreed wih all the other posters, DXM with other SSRI's/SNRI's is just not the risk. IMO DXM was one of the best legal A/D's i've ever tried, but i am a little biased lol. if i were you, i would cut out on the effexor all-together, and take 60mgs-90mgs DXM daily instead.

but again, definitely do NOT mix the two

While you may find it an excellent AD, many other users report creating a deep-seeded depression after doing such things. YMMV, in any case.

 

[Psylex]

Hmm... i'm still quite intrigued by the serotonergic properties. it's been a few nice weeks of effexor, i was still able to smoke weed daily (though i'm still trying to leave the AD work on it's own), as i said earlier i did one 400 mg dxm, and yesterday i took 300 mg codeine on it perfectly nice, then later i ate an E pill (70% mdma, plus speed/coke) while knowing that the SNRI venlafaxine will only cancel out most of the mdma. I haven't experienced any serotonin syndrome symptoms all together, only caffeine and effexor did interact once but nothing else. I'm curious whether, even if everything went well, as for the potential toxicity of all these mixes : increasing serotonin activity at some part of the day then being stable while on a SNRI (safer than a SSRI for these interactions maybe?)

And yes, while not on effexor, i'd rather be doing a few low dose dxm, or a blend of caffeine, ganja, codeine (not too physically addicting of an opiod) with maybe a few xanax/temazepams for smooth night coktails... and on an occasionnal basis, sensible amounts of mdma have been known to act as an AD (once 200-300 mg monthly mdma made me well for long lasting sober days), and lsd/dmt, etc... for mind expansion.

 

[Pjkt2501]

Any and all safety warnings you choose to ignore are done at your own risk.

...I personally wouldn't risk it man. I skipped out on tripping / rolling at 2 shows in the last 3 days (nothing yesterday) because I had taken Tramadol ~42 hours before and didn't want to risk anything. I've been recommended to wait at least 3 days coming off of it before ingesting anything with serotonergic properties.

Codeine doesn't have much, if any, activity on serotonin, though that roll you took was potentially dangerous - was it reagent tested?

 

[Psylex]

Ok so i don't what the real big deal is made around benzos eveywhere, but sometimes i get these occasionnal coctails binges, that is when i have the monthly low quantity prescription 15 mgs Xanax script (while having to be an Venlafaxine) : I took heaps of best ganja/hash, a 300 mg codeine and... in 24 hours just managed to finish the 0.5 mg * 30 Xanax XR (10 mg yestday and 5 mgs today)... having no tolerance whatsover to benzos and not feeling quite alot a bout them (only i did quite feel less the codeine that the day even before, even if it's the less addictive opioid) if it's monthly (last time was even 2 months ago for all that), i shouldn't have any addictive-wise issues with benzos? or any toxic interactions with the rest (codeine, ganja, sometimes speed, lsd/shrooms/ketamine/dmt/mdma) ?!?! Cause yeh i'm stopping high DXM dose while getting rid of Effexor (30 mg for potentiation, 300 mg for 1st plateau but not too far) and pore molly is useless, and is LSD really only giving body high (and pupils wide) with no mental change at all? (i still heard felt and read that both of em are relatively safe with a SNRI)

Fucking doctor wants me to stay on Venlafaxine (Effexor) for 6 months/year!! I say screw that, i don't want to have the venlafaxine withdrawals and not being able to freely test psychedelics... Better come off it as soon as possible and replace with a Bluelight's and Myself Utopian coktails. The doctor himself said that Venlafaxine heals only while on it and not long term it, useless if adding all it's secondary effects IMO

 

[effie]

If you stop an antidepressant treatment within 6 months of recovery, your chances of relapse are a lot higher - that is why your doctor has recommended staying on it for so long.. It treats the episode, but it also protects you against relapses (if it is an effective drug for you). Obviously depression is a lot more complicated than this and psychological/social factors are important too, but that's the general idea..

There is a risk of serotonin syndrome taking anything serotonergic with an SNRI - MDMA, DXM, LSD etc. We can't tell you how high that risk is, but the risk is there. Anecdotally, I know of someone who developed serotonin syndrome combining LSD with tramadol (which has SNRI) properties..

I can't quite follow what you are asking about benzos so am not sure how to answer your question about addiction, how often do you take them? Benzos are pretty non-toxic drugs and there are no interactions with the meds you list except for codeine. They may dampen a stimulant or psychedelic experience however, and if you mix uppers and downers there is a risk than one will mask an OD of the other so go steady there.. The main concern, apart from addiction, is mixing them with other CNS depressants (opiates, alcohol etc) as this really can be very dangerous.

 

[Psylex]

Thanks for your answer... it's weird having serotonergic agents in differents familly of drugs (amphetamine mdma, pschedelic lsd, nmda antagonist dxm.....)


About benzo addiction : i have a 15 mg alprazolam (xanax) script every month (or sometimes every 3 weeks), last time i binge them all in 24 hours, but ususually i take 3 mg/5mg at the time... but i don't really get the recreational value of this molecule : no body feeling (only memorie lost and unhibition), i really don't get the addictiveness of such a molecule...

 

[effie]

The sertonoergic activity is just a property of the drug (like NMDA antagonism) and it's pretty common amongst recreational drugs.

Re the alprazolam.. if you take them all at once over a 24 hour period once a month then you're not going to get physically addicted to them, no. tolerance can still go up though.

If you don't get much from it then probably not much point taking it? Everyone is different. Benzodiazepines as a whole cause physical dependence if taken regularly, and as for the psychological side.. depends on the person, someone may be able to take them or leave them where as others find them very addictive.

 

[pally pete]

If you stop an antidepressant treatment within 6 months of recovery, your chances of relapse are a lot higher - that is why your doctor has recommended staying on it for so long.. It treats the episode, but it also protects you against relapses (if it is an effective drug for you). Obviously depression is a lot more complicated than this and psychological/social factors are important too, but that's the general idea..

There is a risk of serotonin syndrome taking anything serotonergic with an SNRI - MDMA, DXM, LSD etc. We can't tell you how high that risk is, but the risk is there. Anecdotally, I know of someone who developed serotonin syndrome combining LSD with tramadol (which has SNRI) properties..

I can't quite follow what you are asking about benzos so am not sure how to answer your question about addiction, how often do you take them? Benzos are pretty non-toxic drugs and there are no interactions with the meds you list except for codeine. They may dampen a stimulant or psychedelic experience however, and if you mix uppers and downers there is a risk than one will mask an OD of the other so go steady there.. The main concern, apart from addiction, is mixing them with other CNS depressants (opiates, alcohol etc) as this really can be very dangerous.

Yeah tell me about it!
Ive been on Venlafaxine for a good 5 months now and it hasnt helped my depression at all, in fact it's probably worsened it! I tell me G.P/Drug Councillor/Mental health professionals this yet they insist on me continuing to take it. (150 ER per day)

Ive foolishly Taken many Opiates and Tramadol aswell which didnt make me feel good, so OP be warned.