Quick Advice Please Help !! (Morphine ROA and potentiation)

[JMAN914]

Okay so i am an experienced opiate user. 40mg opana has been my drug of choice for the past couple months. I usually blow a whole 40mg opana upon awakening and the same sometimes more when going to sleep. Lately these things have been so hard to come across due to a defect with the pills (so ive been told) and all i can get my hands on are blues (roxies 30mg) which dont do ANYTHING for me. ( i blew 4 at once and didnt really mess me up). I came across 60mg morphine pills and were told they are stronger then blues. So i picked up 4 of them. What is the best way to take them? (i do not touch needles) also i herd taking benadryl helps kick in the pill? I appreciate your answers and concerns.

 

[Pjkt2501]

Diphenhydramine (Benadryl) is a gen-1 antihistamine that is used to potentiate opiates by increase in sedation as well as getting rid of some histamine release (alleviates itchiness).

Oxymorphone (Opana) is best done in small bits at a time, as the active ingredient is less than 10% pill mass (if memory serves correct, this could be off slightly - but not too much). Don't do all 40mg at once - spread it out into 8 lines or so. Sniffing down the whole pill just makes you swallow most of it - effectively giving an oral BA figure (much lower than nasal BA).

Oxycodone ("Roxis" / "blues") have the best bioavailability when taken orally. Much better than nasal, but about double the time for onset. If you must sniff some, then sniff half the dose, and eat the other half.

For your morphine pills - use an online ID website to figure out exactly what you have, and reference the opiate conversion chart at the top of the main page for "Basic Drug Discussion" for an appropriate (safe) dose for you to start at.

 

[ihatepipes]

Okay so i am an experienced opiate user. 40mg opana has been my drug of choice for the past couple months. I usually blow a whole 40mg opana upon awakening and the same sometimes more when going to sleep. Lately these things have been so hard to come across due to a defect with the pills (so ive been told) and all i can get my hands on are blues (roxies 30mg) which dont do ANYTHING for me. ( i blew 4 at once and didnt really mess me up). I came across 60mg morphine pills and were told they are stronger then blues. So i picked up 4 of them. What is the best way to take them? (i do not touch needles) also i herd taking benadryl helps kick in the pill? I appreciate your answers and concerns.

Plug them or you will not feel a fucking thing, hell you will be lucky if you even feel them like that based on the fact that you can snort 40 mgs opana in one sitting without overdosing. IMO I would rather have 4 30mg roxies before 4 60mg MS. I don't know if you IV or not but be careful with IVing mscontin because all kinds of nasties get dissolved into your solution when you prep them. Regardless read up on plugging MS and the bioavailability of other ROA's before you make your decision.

 

[JMAN914]

Just want to say thank you and i appreciate the responces. I read up a little about plugging them but i really dont get the whole concept. If you can explain it to me i would greatly appreicate it. Also im taking these so i dont W/D because i got my first taste of that last week and man it was not fun at all. Btw i have about 4 suboxone and plan on getting clean next week probably. Would i need more? would benzos help? and how about sleep ? Thanks in advanced.

 

[Pjkt2501]

Syringe w/o a needle squirting CWE'd liquid up yer arse.

Benzo's will both potentiate the opiates (as I'm sure you know), as well as aid in WD hell (and sleep). You'll want something long-acting such as diazepam or clonazepam for this.

 

[effie]

Hi there, welcome to BDD! I've edited the title of your thread to make it clearer. Tip - asking for urgent help doesn't mean you will get a reply quicker, you will receive a reply as soon as we can get to you (at least from one of the mods, even if we don't know the answer, we don't leave threads unanswered ) and we are not an emergency service I am afraid

Morphine has a poor oral bioavailability (30% ) and an even poorer nasal one (15-20% ) according to our bioavailoability thread - it also says that rectal has the same bioavailability as oral, but I have heard a lot of anecdotal evidence on here that plugging does work better so it's probably worth a try..

Syringe w/o a needle squirting CWE'd liquid up yer arse.

This, essentially, although if you have morphine pills you don't need to do a CWE as there is no APAP/ibuprofen to remove. A CWE is a lot of liquid to shoot up there too, you'd want to evaporate some I would think!

Your best bet for syringes is oral syringes from a pharmacy - here in the UK you can usually get them for free, they are used for dosing liquid medicines especially for infants or the elderly. 1ml insulin-style syringes like the ones you get from needle exchanges, only with the needle removed, can work but be careful removing the needle (it isn't always possible) and sometimes you want more than 1ml of liquid depending on what you are plugging. 2ml or 5ml oral syringes are best IME, any bigger and it's going to be pretty awkward/painful (plus you don't really want or need to be shooting that much liquid into your rectum!)

Using some kind of lube can help a lot obviously.

There is a plugging megathread here which explains how to do it in more detail!

Plugging is a good ROA for many things as the rectum has a really rich blood supply - things get absorbed quickly, sometimes you even get a rush a la IV (I am glad you want to stay away from the needle) and the bioavailability (how much of the drug makes it into your bloodstream) is generally high. If drugs are subject to significant first-pass metabolism (being metabolised by the liver before they reach the brain, as the blood supply from most of the gut goes via the liver before returning to the heart) then plugging also avoids this.

Good luck getting clean, are you planning on taking 4 Suboxone for 4 days then going cold turkey? Make sure you are in withdrawals before you take your first one, precipitated WDs are not something you want to experience.. I would try to taper the Subs, split the pills up.. benzos will definitely help with some of the symptoms, I would save them for that. Loperamide is also your friend.

 

[ihatepipes]

Morphine has a poor oral bioavailability (30% ) and an even poorer nasal one (15-20% ) according to our bioavailoability thread - it also says that rectal has the same bioavailability as oral, but I have heard a lot of anecdotal evidence on here that plugging does work better so it's probably worth a try...

I have a theory about why people claim plugging produces more pronounced effects even though bioavailability is the same as oral. So why, if the Bioavailability is the same do people claim to feel more of an effect from plugging vs. oral? I cannot say for sure, but I think it has something to do with the fact that the solution takes longer to be absorbed by your stomach vs. your ass. The more rapid absorption of rectal administration leads to a quicker onset and more pronounced initial effects vs a gradual comeup produced by oral administration that may be less noticeable. Somebody has probably already speculated and posted about this already so sorry to waste your time if this is old news for you.



I have posted my method of prepping MScontin for oral/rectal administration because I have done it alot. It is something that took awhile to get right and I have lost some MS in the process.

If I was to ingest morphine I would take it one of three ways: sublingual, oral, or rectal.

A) Sublingual MScontin... Hold the extended release pill under your tongue for as long as it takes to dissolve. It can take quite some time for the tablet to fully dissolve, but I have found that this is an effective ROA. Takes about 15 minutes for a buzz to kick in, but once it does it builds on itself and effects basically increase until the tablet is fully dissolved. Plateau for about an hour with gradual comedown.

B) Oral/Rectal MScontin preparation is the same (I have syringes that I use specifically for oral and syringes that I use specifically for rectal because who really wants to put something in their mouth that was in their ass the day before)...

Put a cup of water in the microwave and boil (make sure the cup is microwave safe I use a pyrex measuring cup).

While the water is boiling pulverize your MScontin and dump it into an oral syringe being careful to hold your finger on the tip so the powder does not leak out. Once you dump the powder in the oral syringe take the plunger and kind of wiggle it into place making sure it is far enough in so that it will not fall out when you turn the tip upwards but not so far in that you build air pressure and blow your MS out of the tip when you remove your finger.

With the plunger in place and still holding the syringe with the tip down turn the syringe so the tip is upwards and flick it with your free hand so that the MS falls down onto the plunger slowly remove your finger (I always hear some air release itself from the tip this is why you want to flick the syringe so you do not blow MS out of the tip).

Push the plunger up until the MS powder reaches the top DO NOT COMPRESS THE POWDER OR IT WILL NOT DISSOLVE COMPLETELY!!!.

Take your hot (just boiled hot) water out of the microwave and go to your sink.

Hold the tip of the oral syringe upright against the side of your cup then slowly pour water over it and draw water into the syringe (I usually get about 5 ml water into the 10 ml syringe), and quickly put your finger over the tip and shake the hell out of it. If you don't do this fast enough the MScontin will gel up and you won't be able to get it to dissolve.

Hold the oral syringe upright with your finger still on the tip and draw back on the plunger while removing your finger (if you don't do this whatever solution is stuck in the tip of the syringe will squirt out and you will lose a few mg of what you put in). This has something to do with the hot water causing expansion of something, (air?) what exactly I don't know.

Now you can push the plunger so the solution fills the tip and turn it upside down into your cup of water and fill the rest of the syringe by drawing back on the plunger. If you do not get all the air out of the syringe before you do this you are likely to lose a little bit of the solution when you turn the tip upwards or downwards.

If I take the solution orally I squirt the solution into my mouth hold it as long as I am comfortable to absorb some sublingually and then swallow.

If I take the solution rectally I follow the plugging faq i.e. have a bowel movement, get something to read/occupy 15 minutes, get comfortable on my left side, lube, plug, relax and allow the solution to absorb for 15 minutes while I read or use the computer (I reccomend you take some baby wipes with you to clean your hands and ass after you plug so you don't get whatever you are going to use to occupy your time dirty).



PLEASE NOTE: I will be back to add to/ revise this post I have other things to do now.