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Opioids Sufentanil... Anyone got any experience with this drug?

flyonth3wall

flyonth3wall

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Joined
Feb 5, 2012
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Doing some research online I find that a 'Sufentanil Transdermal System' is in stage 3 clinical trials.. and will probably soon be coming out with a patch of their own. Is is probably the strongest synthetic opiod ever created, from its analog of fentanyl, and with a potency as strong as 10 times that of original fentanyl. It is currently only used in operating theatres and the like, usually for short acting analgesic qualities combined with anaesthesia to keep a person under and their pain in control while having surgery etc.

Here is the wiki link if anyone is interested: http://en.wikipedia.org/wiki/Sufentanil

Here is another for a company that holds the patents and will be the ones manufacturing the drug in transdermal form: http://www.durect.com/wt/durect/page_name/trans_sufentanil

Obviously this drug, legally, is only in testing stages still when it comes to the transdermal form, and will probably be a while before it appears on the open market for use by chronic pain patients, but thats not to say that other non-legal labs haven't tried, or indeed actually manufactured their own Sufentanil. When it comes to the IV/IM/SC formula, this is already developed and in use.

Also, obviously, with this drug being as strong as it is - 10mg of IV Morphine would be equivalent of 0.014mg of IV Sufentanil ( lol wow ) - I guess this is a drug not to be fucked with to put it lightly...

But, still have to ask... Has anyone ever had any experience with this crazy ass drug outside of a hospital enviroment?
 
No worries dude... this extremely potent opiod interests me immensely as well... No-one else got any input?
 
They say this drug causes serious respiratory depression. Fentanyl and any of it's analogs are opiods I would never fuck with. For starters the euphoria is shit compared to morphine and heroin, and it's potency makes overdosing far too easy.
 
-Guido- said:
They say this drug causes serious respiratory depression. Fentanyl and any of it's analogs are opiods I would never fuck with. For starters the euphoria is shit compared to morphine and heroin, and it's potency makes overdosing far too easy.
Click to expand...

I agree. In fact, I read that researcher are purposely developing fentanyl analogues for their high potency and lack of euphoria. I doubt a drug like this would be too much fun, regardless of how potent it is.
 
Fentaynal sucks IMO coming from someone smoked 3 100mcg patches a day they got no euphoria
 
^^ I find fentanyl doesn't give much euphoria either, just a nice relaxed, dreamy state, slightly sedating high.. I don't use my meds to get fucked off of them, so the euphoria being absent doesn't bother me much tbh. And I'm not saying that I actually want to use sufentanil, it just interests me thats all, hence the thread.
 
I would probably give it a whack and od trying eat/smoke like fentynal happened new to fent chasing that euphoria thankfully baby mama a nurse or m a
 
^What?
__
And I don't see how any company can expect to market this without having to deal with massive amounts of ODs. No matter what matrix/mechanism they form to make it "abuse-proof", people will find a way to defeat it. I personally love the fentanyl patches; the nod is amazing, even if the euphoria is slightly lacking compared to other opioids. That's just my .02
 
Curiously though, why synthesise a drug x10 stronger the fentanyl when there are already opiates with said potency?

I was under the impression these stronger opiates weren't used in medicine since the dose-response was so steep they're too dangerous to use. No?
 
I used to shoot Fentanyl pops - OD'd a few times, even though my tolerance was through the roof. I can't imagine doing anything stronger - I really wouldn't recommend it.
 
fentanyl and its analogues have seriously high binding affinities that drive tolerance way up some of them on the level of things like Oxymorphazone an irreversible binding agonist that forces receptor lysis. these drugs are strong but they are also brutal on your tolerance.
 
I think there also seems to be this prevailing opinion with people that use opiates (not so much on BL really, more with addicts that I've met personally), that strongest = best, and that really is just not true. Drugs like heroin and oxycodone are IMO way more euphoric than fentanyl and dilaudid, and using these super potent opioids, like theblueletters said, is just going to jack your tolerance through the roof
 
theblueletters said:
fentanyl and its analogues have seriously high binding affinities that drive tolerance way up some of them on the level of things like Oxymorphazone an irreversible binding agonist that forces receptor lysis. these drugs are strong but they are also brutal on your tolerance.
Click to expand...

WHAT!? This drug actually IRREVERSIBLY forms a covalent bond with your receptors?!? WHAT!? Can someone with some pharmacology/neuroscience background tell us what this means exactly.
 
Little late and less than technical, but oxymorphozone binding irrevocably to the receptor (unfortunately IMO) doesn't mean it will last forever - just that it will remain covalently bonded to the receptor as long as the receptor 'lives' or remains 'in play' if you will. Not sure how long that would otherwise be, but once oxymorphozone is bonded, the receptor is reabsorbed/recycled/replaced (I forget the technical term) in about 48 hours, meaning the effect doesn't last more than two days. OTOH naloxone type antidotes (antagonists) will be useless in the case of an OD making it very dangerous in that respect; treating an overdose would prob entail 24+ hr's of iv epinephrine and artificial respiration if they somehow figured out what you'd even OD'd on
 
I had last august several surgical procedures on my right arm because i developed a compartment syndrom after an OD. Usually they would give me propofol followed by sufentanil because of my known addiction problems. But this time i had lost massive amounts of blood and they emergency sheduled me from the ICU to the OP. The anestetic didnt care if i was addicted or not they had other problems right then. ;-) So she started with the injection of sufentanil first. I didnt ask specifically what drug it was this time, because i was too weak and dizzy because of my low blood amount and was already sedated from i.v. lorazepam and oxycodone. At first i felt only the slight opiate buzz increasing, shortly followed by a clear opiate high and a nice warmth that engulfed my weak body. I thought nice to myself, my panic was complety washed away, and i felt no pain. Seconds later my whole body and vision was intensly vibrating with echoing accustic. And then i was out black. It was an intense syntetic rush, and from then on i knew why they would start with propofol othertimes, hah.
 
Does this still need to go through FDA approval? An FDA advisory board just recommended AGAINST the approval of an extended release pure hydrocodone tablet, so I don't see how they could approve freaking sufentanyl of all things.

I saw a youtube video where a woman who was on 1G (that's right) of methadone per day was having appendix surgery and she was being administered sufentanyl directly via a pump to try and control her pain and it still barely worked. This was shocking to me but a gram per day methadone tolerance is nothing to be taken lightly lol
 
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