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cell cycle

noooooo i hate ADD they always edit and delete my threads and make fun of me :(
 
Well you do not exactly formulate your questions very well, and you show a general lack of initiative to educate yourself through easy to find information as opposed to wanting people to figure stuff out for you.
 
Shimmer.Fade said:
Well you do not exactly formulate your questions very well, and you show a general lack of initiative to educate yourself through easy to find information as opposed to wanting people to figure stuff out for you.
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man you know its frustrating when little info is available out there right ? well, opposite is also true. when there is too much info available out there. ocean of information, so much so, im lost. i really can go on for days, gather up info then i have to go through it and gather what i need but its even more difficult when there is so much info that you have to actually separate false info from truth. and trust me, when there is so much put out there tnx to the internet, its mostly crap.
most important i must say is, I WANT TO COMMUNICATE WITH ACTUAL HUMAN BEINGS, NOT GOOGLE. why are you guys so programmed in such way you only know google as the holy God but human interactions are put aside ? its not so much called "relying" on others as a spoiled kid AS MUCH AS WANTING TO COMMUNICATE WITH ACTUAL HUMAN BEINGS.

jeez.... fucking... christ
 
Lol..just suggesting why people in ADD might treat you the way they do. I know not everyone has a scientific background, and that is why I gave you some useful information to get you on the right path.

The rest is up to you. It is pretty obvious that although you might be interested in these things that you lack some education in very important, foundation building areas.

Maybe some people here don't like the image that you project of wanting all the answers without investing time yourself. Some people here have probably invested enormous amounts of themselves in order to have the knowledge that they have, and they rightfully expect that people with a true interest in these things will also invest themselves somewhat.

There is a reason why scientists, doctors, and the professors who train these professionals get paid to do what they do.

This isn't a university, and I'm pretty sure you don't pay anything to use bluelight specifically, so you should be thankful for any helpful information that you receive.
 
Shimmer.Fade said:
Lol..just suggesting why people in ADD might treat you the way they do. I know not everyone has a scientific background, and that is why I gave you some useful information to get you on the right path.

The rest is up to you. It is pretty obvious that although you might be interested in these things that you lack some education in very important, foundation building areas.

Maybe some people here don't like the image that you project of wanting all the answers without investing time yourself. Some people here have probably invested enormous amounts of themselves in order to have the knowledge that they have, and they rightfully expect that people with a true interest in these things will also invest themselves somewhat.

There is a reason why scientists, doctors, and the professors who train these professionals get paid to do what they do.

This isn't a university, and I'm pretty sure you don't pay anything to use bluelight specifically, so you should be thankful for any helpful information that you receive.
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good point. i wasted your time asking information, so its logical in this modern society to ask, how much do you want ?
 
Aescin said:
I WANT TO COMMUNICATE WITH ACTUAL HUMAN BEINGS, NOT GOOGLE. why are you guys so programmed in such way you only know google as the holy God but human interactions are put aside ? its not so much called "relying" on others as a spoiled kid AS MUCH AS WANTING TO COMMUNICATE WITH ACTUAL HUMAN BEINGS.
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Remember when I asked you for evidence in your thread on stearic acid and you linked me a google search? :P :P
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I'll leave this open if we can steer discussion back on track. We may want to look specifically at the time course of hepatic cellular replication and the mechanisms behind what enduring toxicity there is. We may also want to talk about what case is to be made for the possibility of neurogenesis in the wake of toxic insults.

ebola
 
ebola? said:
Remember when I asked you for evidence in your thread on stearic acid and you linked me a google search? :P :P
...
I'll leave this open if we can steer discussion back on track. We may want to look specifically at the time course of hepatic cellular replication and the mechanisms behind what enduring toxicity there is. We may also want to talk about what case is to be made for the possibility of neurogenesis in the wake of toxic insults.

ebola
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"We may also want to talk about what case is to be made for the possibility of neurogenesis in the wake of toxic insults."

thats interesting, can you explain more ??
 
Wikipedia is your friend:

Cell cycle:
The fastest cycling mammalian cells in culture, crypt cells in the intestinal epithelium, have a cycle time as short as 9 to 10 hours. Stem cells in resting mouse skin may have a cycle time of more than 200 hours.
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The only other concrete example I can give is nerve cells, which never divide after about ~2 years of age (except for a small pool of stem cells in the subgranular zone and subventricular zone).

If you're talking about in living animals, I would think that would be extremely difficult to measure due to constant turnover/death of previously labeled cells, and not knowing how many cells died since you last labeled.
 
If you are interested ebola? and Sternam...

Mitosis itself, when all check points are met without being arrested at some point, is pretty much the same for all cells. Cells which need to produce more organelles or proteins than an average, undergo post-mitotic modification, etc... will take usually a bit longer. The biggest regulator of the cell cycle itself is usually not material production, rather outside signals. This stuff gets really complicated because you start involving the factors that keep cells, when given unlimited building blocks, from continually reproducing. Different cells have different cycles depending on their intended function. As stated the intestinal epithel can reproduce itself very quickly. For instance, typical olfactorial/smelling cells (not sure if this is the right english term, Riechzellen in german) last for about 60 days, and are replaced by basal cells which lay atop the basal lamina (which is fairly typical for most stratified tissues that having actively replicating cells to replace the tissue).

Normal hepatocyte lifespan is ~5 mos assuming that nothing toxic kills it. Without having read the details in awhile to be sure I would think in the liver (and most other places in the body) that when a cell dies it releases certain chemicals into its surrounding area, which would in turn stimulate neighboring hepatocytes to reproduce themselves.

However, if the liver is chronically inflamed due to whatever cause the cell death rate is higher than normal, and the hepatocytes are most likely not able to cover the extra damage. This leaves space within the liver that is not being filled by anything except probably the various liquids in the liver. The Ito-Cells come into play parallel with increased cell death, as increased cell death releases inflammatory factors locally which then change the Ito-cells from their inactive to their active state. The Ito-Cells then start secreting collagen which fills in some of the gaps. Lipocytes are also involved with filling in the empty space, and I'm sure some is actually filled with healthy hepatocytes.

So, the actual mitosis of a hepatocyte is probably a tiny bit longer than an average cells because hepatocytes have quite the specialized structure (very well developed sER for biotransformation), but, excluding a halt in the mitosis along the line somewhere, I would imagine that mitosis for hepatocytes it not noticeably different from an 'average cell'. It all depends on factors from outside the individual cell that will trigger said cell to replicate as to how often this occurs. Therefore, the time of replication for hepatocytes somewhat variable depending on cell loss.


To answer your question specifically ebola? ..I don't think their is 'enduring' toxicity in the liver per se. Usually the liver filters/breaks down toxic things well enough that it is only the acute toxicity of the various substances which, if the liver's mechanisms were saturated, simply keep going with the blood. There are definitely some substances that are pretty horrible for the body which the liver can't break down, and may be hard to excrete (through kidney filtration) that lead to pretty nasty problems. These are pretty rare, and most of the time much care is given in keeping these substances out of the human body.

Neurogenesis, as you know is still being researched pretty heavily. I would have to dig around for awhile to find anything concrete, and right now I don't really have the time. I have one instance on hand, though not typical to the nervous system in general. The olfactorial cells whose axons make up the fila olfactoria are neurons that like I said above have an average life cycle of about 60 days. The basal cells then receive signals that tell them to fully differentiate into mature olfactorial cells. I'm not sure how differentiated the basal cells already are.

Edit: I wanted to add that I forgot to mention that death of hepatocytes due to pathological reasons is also dependent of the location of the cell within a liver acinus. The further away from the Glisson-Trias direction Vena Centralis a hepatocyte is, the less oxygen the cell will receive.
 
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Glad it was useful! I stumbled upon this information pertaining to adult neurogenesis while studying today, and I thought might be interesting.

http://en.wikipedia.org/wiki/Subgranular_zone

I don't know how accurate the information is because I haven't read through the wikipedia article to compare the information with my books, but it should serve as a decent list of the names of the things involved if anyone wants to dig deeper.
 
Shimmer.Fade said:
Glad it was useful! I stumbled upon this information pertaining to adult neurogenesis while studying today, and I thought might be interesting.

http://en.wikipedia.org/wiki/Subgranular_zone

I don't know how accurate the information is because I haven't read through the wikipedia article to compare the information with my books, but it should serve as a decent list of the names of the things involved if anyone wants to dig deeper.
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"Wnt and bone morphogenic protein (BMP) signaling also are neurogenesis regulators, as well as classical neurotransmitters such as glutamate, GABA, dopamine, and serotonin"


so basically drugs like stimulants, opiates, or alcohol induce neurogeneses. as if i didnt know that by now.
i wonder whats the solution to not using drugs and stimulating those "classical" neurotransmitters...
 
I've always heard the pink tissue inside the mouth regenerates the fastest, I think something to do with resisting the enzymes in your mouth. But iirc also makes these tissues more susceptible to cancer.
 
Yea, most cells/tissues with a higher level of replication are often more susceptible certain carcinogenic material or processes. This is in general partly due to the replication controls being more complex within these cells in order to replicate often when necessary, but not to constantly replicate. Also, it is partly due to many of these tissues being more exposed to carcinogenic materials (i.e. mouth, trachea, intestine, skin). There areas are also sometimes areas of high replication.
 
aescin said:
well thats what i have witnessed from experiences. whats more vital in life but through own experience ?
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You can't witness changes in neurogenesis from personal experience, unless you've been giving yourself cranial biopsies. :P

ebola
 
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