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4-EAR (4-Ethylaminorex) any info?

S

snubi

Bluelighter
Joined
Sep 25, 2011
Messages
78
Im getting this substance in the near future, but cant find any info at all.

I was able to find a wiki page for 4-MAR:

http://en.wikipedia.org/wiki/4-Methylaminorex

4-Methylaminorex has effects comparable to methamphetamine but with a much longer duration.
Click to expand...

4-Methylaminorex dosage::

As a recreational drug, the effective dosage ranges from 5 to 25 mg
Click to expand...


Anyone care to speculate on dosage, effects, duration. Of 4-EAR vs 4-MAR?
 
I would also like to know how this compares with 4-MAR. Should have it in a couple of weeks, but I won't be going near it until I have atleast seen a few reports and much more info...

Legality wise also!
 
I'm also looking for some info on this one, if it's anything like 4-MAR I can't imagine it remaining legal for long.
 
Im going to order kilo's of this, as soon as i verify its properties
 
This is relevant to my interests. I've wanted to try 4-MAR for almost a decade.
 
Though the initial inquiry for further information about the substance in question is viable for ADD, I question whether everyone's interest is being piqued by presumably a propagation amongst vendors from a sole source.

If so, then it becomes rather basic RC discussion, too lenient on advanced community contribution for my liking. It would bring into question whether we can even ascertain what truly is being sold by such a name. etc.
 
Indeed; this thread needs something more informative than, "I'd like to take that, bro." :P
That said, I carry no such data, so I can't level severe criticism.

ebola
 
Well I only have been looking at 4-MAR and have speculative information about that but my knowledge doesn't reach that far pharmacology-wise; I have no clue what diffirence there is made with exchanging for an ethyl.

:!

Certainly someone can shed some light?:)
 
I'm at work so I don't have the time on my hands to do something like this, but I am also excited about 4-EAR's imminent public release.

To get a good *approximation* of an idea regarding 4-MAR's effects, compare the binding affinities of aminorex and 4-MAR.

4-EAR's affinities *should* be somewhere in between aminorex and 4-MAR for NET and DAT; I come to this conclusion using amphetamine and cathinone SAR. However, since amphetamine and cathinone have negligible affinity for SERT to begin with, and aminorex seems different in this sense (strong anorectic effects) it is entirely possible that the 4-ethyl homologue might retain some serotonergic activity, in contrast to ethamphetamine and especially ethcathinone.
 
Of course we're not talking about a benzene ring substitution; I made references to ethamphetamine and ethcathinone...I realize that these aren't exact clones of aminorex but they should give us a general idea of how 4-EAR will be.
 
N0 W4RN1NG said:
Of course we're not talking about a benzene ring substitution; I made references to ethamphetamine and ethcathinone...I realize that these aren't exact clones of aminorex but they should give us a general idea of how 4-EAR will be.
Click to expand...

Well, not really. Even if the methyl were in a remotely analogous position, it would still be a huge leap to make generalizations from amphetamine SARs to aminorex SARs.

I wonder if it will also be a 5-HT2B agonist like aminorex is and 4-MAR probably is. If not, it could be very promising, not only as a recreational drug, but for therapeutic applications. The aminorex compounds are potent, effective psychostimulants which (with one known exception) lack neurotoxicity. If it weren't for aminorex's 5-HT2B agonism, it would still be on the market I bet, maybe even a preferred treatment option for ADHD and other stimulant indications.
 
atrollappears said:
Well, not really. Even if the methyl were in a remotely analogous position, it would still be a huge leap to make generalizations from amphetamine SARs to aminorex SARs.

I wonder if it will also be a 5-HT2B agonist like aminorex is and 4-MAR probably is. If not, it could be very promising, not only as a recreational drug, but for therapeutic applications. The aminorex compounds are potent, effective psychostimulants which (with one known exception) lack neurotoxicity. If it weren't for aminorex's 5-HT2B agonism, it would still be on the market I bet, maybe even a preferred treatment option for ADHD and other stimulant indications.
Click to expand...

Other then the pulmonary hypertension; http://www.bluelight.ru/vb/threads/596256-Question-concerning-4-Methylaminorex?highlight=4-methylaminorex

edit: excuse me; seems I read right past your ( )
 
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N0 W4RN1NG said:
I'm at work so I don't have the time on my hands to do something like this, but I am also excited about 4-EAR's imminent public release.

To get a good *approximation* of an idea regarding 4-MAR's effects, compare the binding affinities of aminorex and 4-MAR.

4-EAR's affinities *should* be somewhere in between aminorex and 4-MAR for NET and DAT; I come to this conclusion using amphetamine and cathinone SAR. However, since amphetamine and cathinone have negligible affinity for SERT to begin with, and aminorex seems different in this sense (strong anorectic effects) it is entirely possible that the 4-ethyl homologue might retain some serotonergic activity, in contrast to ethamphetamine and especially ethcathinone.
Click to expand...

Looking at how this drug has the potential for serious side effects like pulmonary hypertension, its probably best to leave alone before someone kills themselves with it.

Also, stay the fuck away from this place N0 W4RN1NG before you get your ass thrown back in jail. I read your zoklet threads, why the fuck do you do this to yourself?
 
An interesting drug to be sure. Are there any known N substituted methylaminorex prodrugs? A carbamate perhaps?
Click to expand...

4-substituted aminoreces last long enough already, so I don't see how exploration of prodrugs would prove useful, unless there is a substitution that is cleaved extremely rapidly (like on the order of the likely bioconversion of psilocybin to psilocin). Lysine is cleaved extremely rapidly from Vyvanse, and it lasts twice as long as d-amphetamine.

I believe nitrogen substitutions of such compounds to be largely unexplored.

EA said:
Looking at how this drug has the potential for serious side effects like pulmonary hypertension, its probably best to leave alone before someone kills themselves with it.
Click to expand...

Well, MDMA and MDA share these toxicities, and they are safe enough to be viable recreational compounds. These toxicities raise their heads with daily dosing of one year or more.

ebola
 
Epsilon Alpha said:
Looking at how this drug has the potential for serious side effects like pulmonary hypertension, its probably best to leave alone before someone kills themselves with it.

Also, stay the fuck away from this place N0 W4RN1NG before you get your ass thrown back in jail. I read your zoklet threads, why the fuck do you do this to yourself?
Click to expand...

Hmm, feeling a little hostile? I hope you know that my stays in jail had nothing to do with my involvement with totse\zoklet, I was selling drugs and got ratted out; I chose to step down as moderator because I wanted to distance myself from the scene, not because I was being watched.

I am still voraciously interested in pharmacology and plan to go on to become a psychiatrist, and I still use (unbanned) synthetic cannabinoids occasionally as well as unbanned stimulants sometimes for work\school purposes.

I hardly think I risk going back in. Either way, huge derail, sorry, I just felt it necessary to defend myself.
 
ebola? said:
Well, MDMA and MDA share these toxicities, and they are safe enough to be viable recreational compounds. These toxicities raise their heads with daily dosing of one year or more.
Click to expand...

Depending on the compound it may be as little as a few months, and a compound with a more stimulant profile is more likely to be used in binges than an entactogen.
 
ebola? said:
Well, MDMA and MDA share these toxicities, and they are safe enough to be viable recreational compounds. These toxicities raise their heads with daily dosing of one year or more.

ebola
Click to expand...

Post marketing surveillance on aminorex shows significant increases in long term pulmonary hypertension even after a few months of non-recreational use.
although aminorex-induced pulmonary hypertension in humans often progressed after the drug was stopped, it did regress in 12 of 20 patients followed for >17 years; ie, the pulmonary vascular disease in these patients appeared to be reversible
Click to expand...
Granted there seems to be a strong genetic component.
http://circ.ahajournals.org/content/99/1/156.long

Also, this class of drugs seems to have the potential to induce long lasting changes to the structure of the heart which may continue to evolve and result in problems long down the road.
http://www.ncbi.nlm.nih.gov/pubmed/3738463?dopt=Abstract
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~rrSuKY:1:htox

Can't find any definitive info on its 5HT2B affinity, but its still a very worrying possibility that it is a potent agonist.
http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=7

But, seeing as the RC stim crowd is binge happy if a side effect can happen it generally will happen.
 
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