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Nootropics of the future

L

Lombergerh

Bluelighter
Joined
Oct 1, 2010
Messages
65
So, we already have stimulants, dissociatives and sedatives of the future, why not to discuss this subject.
 
Lombergerh said:
If the composition of the supplement the same as written on the label(piractem+dmae e.t.c) i think it wouldnt do much andcertainly can't overpower addral or dexedrine.
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I certainly don't need anymore adderall, check out my latest blog, that's what I'm doing every other day, of course it doesn't do the same as adderall but it's a healthier alternative with noticeable but not overpowering effects that you'd get with prescription amps.
 
atara said:
I've used Noopept for a while. It seems to do more for reaction time than focus, oddly.
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Is it really helpful?
It's synthesized in Russia and now here we have so many "purely promotional" drugs which lacking any evidence for activity.
I really miss about Mesocarb, in my opinion it was a nice pure stim without many toxic effects of amph, strictly for cognitive and physical perfomance.
 
ebola? said:
Of the future?
AMPA agonists and modafinil analogues?
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Yeah, i think the same, but why not to go through peptidies or nmda-antagonists.

Also I think that somebody posted really interested substance named 4-fluro-adrafinil or like that, it's a just thinking or it was described in any papers?
 
What peptides would you be referring to?

Also I don't think an NMDA antagonist could be useful as a nootropic. Drugs like ketamine and methoxetamine which are not even full antagonists (I consider them more as negative allosteric modulators) are just too bewildering and psychedelic to be used strictly as a nootropic, or at least according to my definition of nootropic. I think any nootropic should be able to be used daily for extended periods of time with little to no adverse effects; drugs that are benign enough to be taken before work or school.

But if there is an NMDA modulator/antagonist you are aware of that is not like K or MXE then lets have it. ;-P
 
Semax, selank, cerebrolysin?
But what about memantine it's nmda antagonist and used as nootropic supplement.
 
I want to see some orexin agonists and 5HT6 antagonists, fortunately the latter is going to be the next generation of dementia meds.
 
5-HT4 agonists/partial agonists. I believe there's several in the works for Alzheimer's

oooh, or maybe something starting from Losartan, an angiotensin-II receptor antagonist (blood pressure medication). It was found to reduce deficits caused by scopolamine and improved memory in healthy subjects. So we already know it improves memory for us normal folks, and not just those with various dementias.
 
There are some newer drugs called AMPAKines (Any guess what they do? :P ).. they are derived from Aniracetam and have shown some good nootropic effects. Not sure if they are on the market yet though.
 
SNR said:
There are some newer drugs called AMPAKines
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ebola? already mentioned them early in the thread e.g. "AMPA agonists"

Sturnam said:
5-HT4 agonists/partial agonists.
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What has 4 been discovered to do in terms of nootropics in contrast to the other serotonin receptors? I only skim across info on gastrointestinal motility for the four subtype.
 
Lombergerh said:
Is it really helpful?
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It has an effect. It's great for video games, but it's not helping with a problem I refer to as "slacking off all the motherfucking time", so I'm going to order some aniracetam. It does seem to decrease reaction time and increase "immediate" focus.

My experience is not typical; Enkidu said it worked well for him. Your mileage may vary.

What has 4 been discovered to do in terms of nootropics in contrast to the other serotonin receptors?
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Promotes acetylcholine release, IIRC.
 
But have anybody tried something from AMPA-family? Excep from aniracetam, i mean "really" ampakine, they aren't available on the market, but possibly to buy from some legit china pharma company, or may be someone from bluelight working at Cortex Pharmacueticals?)

Also is there any place where i can read about all undergoing researches in nootropics and cognitive stimulants area, 'cauz wikipedia seem lacking some really interestin information.
 
Lombergerh said:
Semax
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Yeah I tried this one a few times and didn't get much of anything noticeable, even after very large intranasal doses. I don't think it is worth pursuing.

Memantine, this is interesting to me at least as I was studying up on the ketamine literature just last month, and it has a distinct mode of action from ketamine (and probably MXE) to block the channel like Mg2+. But after reading the wikipedia page, I think it is an old enough compound that if it did anything useful it would probably be more widely used by now- such as piracetam is.

Unless there are a bunch of closet memantine-heads out there secretly getting their fix? Lol, I doubt it.

An orexin agonist, yeah part of the problem is compound administration- How well can you get a peptide like orexin A into the brain through the nose? And perhaps more importantly does it even do anything useful?

I don't think I have read any papers on human use of orexin A actually. But I did just find one that was published recently, and it doesn't sound like it did that much... certainly not the reversal of narcolepsy they were probably hoping for. I think delivery could be a big problem for this one first and foremost.

Sleep Med. 2011 Dec;12(10):941-6.
Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy.
Baier PC, Hallschmid M, Seeck-Hirschner M, Weinhold SL, Burkert S, Diessner N, Göder R, Aldenhoff JB, Hinze-Selch D.
Source

Department of Psychiatry and Psychotherapy, Christian Albrecht University, Niemannsweg 147, D-24105 Kiel, Germany.
Abstract
BACKGROUND:

The neuropeptides hypocretin-1 and -2 (hcrt-1 and -2, also known as orexin A and B) are crucially involved in the regulation of sleep/wake states. On the one hand, the sleep-wake disorder narcolepsy can be caused by an hcrt-1 deficiency. On the other, intracerebral administration of hcrt-1 produces an increase in wakefulness at the expense of REM sleep in normal and narcoleptic animals. In humans intranasal administration has been shown to effectively deliver neuropeptides directly to the central nervous system. We hypothesised that the intranasal application of hcrt-1 increases wakefulness and reduces REM sleep in the natural human hcrt-1 deficiency narcolepsy with cataplexy.
METHODS:

In this double-blind, random-order crossover, placebo-controlled, within-subject design study we administered human recombinant hcrt-1 (435 nmol) intranasally to eight subjects with narcolepsy with cataplexy before night sleep, followed by standard polysomnography.
RESULTS:

Although intranasal administration of hcrt-1 had no statistically significant effect on nocturnal wakefulness, we found that it reduced REM sleep quantity, particularly during the second half of the recording. Furthermore, intranasal hcrt-1 had a clear REM sleep stabilising effect and led to significantly reduced direct wake to REM transitions.
CONCLUSION:

In this pilot study we found, first, evidence that the intranasal administration of hcrt-1 has functional effects on sleep in narcolepsy with cataplexy. Our results may encourage the use of the intranasal approach in further studies on hypocretinergic sleep regulation and might also contribute to the future development of a causal treatment for narcolepsy with cataplexy.
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Doesn't the study heavily imply that the drug only helped people suffering from narcolepsy, or did I misinterpret it?
I guess they didn't include any healthy control subjects so it might just be a bold extrapolation.
 
orexin is one of those things that seems involved in everything good, while having no smoking gun links to being directly responsible for it.
If we did get a selective orexin agonist it would probably be a mildly euphoric, appetite stimulating stim.
 
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