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5-Methyl-MDMA

^Xayo

^Xayo

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Nov 2, 2010
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So recently I read through alot of MDxx articles on wikipedia and I found 5-Methyl-MDA, the wiki article states its approx. 5 times the potency of MDA. I wonder why no one ever came up with MADAM-5 ? Considering that bk-MDMA is only one atom away from MDMA and is sold widely why shouldn't be MADAM-5 be threated the same way, even introducing a (possibly?) higher potency chemical than MDMA itself.

For people who can't comprehend english my question is explained in graphical form in the attachments


Greetings Xayo
 

Attachments

  • 5mmdma.png
    5mmdma.png
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Aye. Given how drastically 5-methyl-mda differs from closely related compounds in TiHKAL in activity, this is unexplored space.

ebola
 
5-methyl MDA is more of a true psychedelic than an MDA/MDMA type drug. N, methylation of psychedelics often drastically reduces potency, though whether that would be true in this case IDK.
 
The N-methyl of MMDA-1 has been tested and found to be active; I imagine 5,N-dimethyl-MDA would have a somewhat higher SERT affinity than 5-methyl-MDA but be a much less potent serotonin agonist, bringing its effects profile closer to that of IAP.

This is because N-methylation of amphetamines seems to increase SERT affinity (MDA vs MDMA, amphetamine vs methamphetamine) but decrease 5-ht agonism.
 
if you look around you can find a few trip reports on the substance, dosage is around 15-25mg I guess it just recently became available.
 
LMAO @ Chinese chemists trying to use BL to make new drugs. "threated" being a dead give away. I won't even comment on the rest...
 
FYI there is no known way to improve the potency of the MDMA molecule at this time. MDMA is a very unique drug. I have sampled true 5-Methyl-MDA and while it is much more potent, it is not MDMA. On top of that, it degrades quite quickly to an inactive molecule. Your post is taking into account studies done on animals, not humans. MDMA is a complex drug with many facets that are still not understood by science. I do not know what makes people think that they have the "next big MDMA analog"... Mephedrone was a lucky strike... And it still was much more like a mix of cocaine and amphetamine than MDMA IMO. Methylone came closer but still didn't hit the mark.

When will people give up on trying to recreate MDMA into something that can be sold legally for personal gain? How many people have to die, how many hospitals, etc... /end rant.
 
The Big Dandy 5-Methyl MDA Thread

I wouldn´t listen too much to magical cat. He was the one hyping this drug before it was made available for a short time.

Most people took 100-150 mg with only treshold, or no, effects. The batch was verified in a lab as being real 5-methyl-mda.

This chem proved to be bunk, and it will be very unlikely it will be ever offered again.
 
^Thats pretty interesting if true since both the 5-methyl and 2-methyl MDA compounds were shown to have stronger action than MDA at SERT as well as better substitution than MDA in rats trained for serotonin releasing agents.

Parker, M. A., D. Marona-Lewicka, et al. (1998 ). "Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)." J Med Chem 41(6): 1001-1005.
 
Fagott said:
The Big Dandy 5-Methyl MDA Thread

I wouldn´t listen too much to magical cat. He was the one hyping this drug before it was made available for a short time.

Most people took 100-150 mg with only treshold, or no, effects. The batch was verified in a lab as being real 5-methyl-mda.

This chem proved to be bunk, and it will be very unlikely it will be ever offered again.
Click to expand...

I received a sample from a very well-known vendor LONG before the "other" vendor offered it and whatever he sent me was definitely active. I gave it to another person and he had a similar experience as mine. The vendor that popped up with it for sale after the original lab gave up on the synth (same one that was looking into offering a certain chemical that was supposed to be similar to cocaine but scrapped that project as well, and also the one I obtained my sample from) ended up being a scam on pretty much everything. That's not my fault and I've already apologized for it time and time again and I will not entertain the constant apologies anymore. I had a pretty good reputation here before the 5-Methyl-MDA debacle and I've been a member here a long time. I didn't have any financial gain from the bunk stuff that was offered - on top of that I did receive a sample as well and found that particular sample to be entirely bunk which I posted about on another forum. I spent a number of hours working with said vendor to try to figure out why it was inactive they even tried different salt forms, etc... It could be that the synthesis route that they used turned out real 5-Methyl-MDA but with a different structure from the first sample I received from the other bulk vendor. Who knows.

Anyway as I said I don't see any value in 5-Methyl-MDMA. 6-Methyl-MDA maybe but nobody seems to have any idea how to make a route to synthesize that one.
 
Going by the paper I posted above, the 6-methyl versions are the weakest of the lot so maybe the bunk 5-methyl stuff was actually 6-methyl and perhaps the analysis missed that? Even if the methylated MDMA versions are not replacements of MDMA or even like MDMA at all doesn't necessarily mean they wouldn't be worth trying. Regardless of the legality of them or MDMA.
 
chaos_destroy said:
Going by the paper I posted above, the 6-methyl versions are the weakest of the lot so maybe the bunk 5-methyl stuff was actually 6-methyl and perhaps the analysis missed that? Even if the methylated MDMA versions are not replacements of MDMA or even like MDMA at all doesn't necessarily mean they wouldn't be worth trying. Regardless of the legality of them or MDMA.
Click to expand...

Wasn't it just NMR data posted for the supposed 5-Methyl-MDA anyway? And I might concur on that notion but even at 150mg, which *should* have been active if it was 6-Methyl, I didn't feel a thing from that second batch. Maybe some slight tingles like something might be *starting* to happen but nothing concrete.

Also the synthesis route that they used was made to work around a certain chemical (synthesis discussion so I'll leave out the name) that is highly effective at depleting the ozone layer and is banned in most all countries, including China. This is the very reason the first company decided it wasn't possible to make in large batches as even though they are based out of Thailand, their labs are in China. It is quite possible that somewhere in the synthesis this work around botched the end result.

EDIT: Also I am trying to find the thread but one of the extremely knowledgeable ADD people described why 5-Methyl-MDMA would probably have no activity at all.
 
Last edited:
atara said:
The N-methyl of MMDA-1 has been tested and found to be active; I imagine 5,N-dimethyl-MDA would have a somewhat higher SERT affinity than 5-methyl-MDA but be a much less potent serotonin agonist, bringing its effects profile closer to that of IAP.

This is because N-methylation of amphetamines seems to increase SERT affinity (MDA vs MDMA, amphetamine vs methamphetamine) but decrease 5-ht agonism.
Click to expand...

the n-methylated versions of DMMDA, DMMDA-2, TMA-2, and PMA have also all been made and found to be active, just weaker. in the case of DMMDMA, DMMDMA-2 and TMMA-2 it's supposedly remarkably weaker. citing the old hive archives, posts by antibody and chromic
 
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