MDPV - so how dangerous to your body is it?

[vicapro]

Clonidine may diminish some of the negatives but by doing that it will diminish the wanted effects as well (ime it actually made my bp real low but my heart rate stayed high when I would binge all day vaping after taking clonidine in the morning at .1mg which is the lowest dose). This in turn would exacerbate the cardio issues when moving around because it mimics orthostatic hypotension. In other words just in my experience clonidine really diminishes the positives of stimulants because of the inhibition of norepinephrine which negates much of the stimulation which goes hand in hand with dopamines euphoria to make produce the wanted psychoactive efffects. Taking it when your coming down or in an overdose situation on the other hand would be beneficial and take away many of the lingering unwanted side effects. Each time I felt that clonidine negates too much of the positives to warrent its use for the negatives of binging on mdpv

 

[ebola?]

It's my opinion that compounds requiring coadministration of an anxiolytic or adrenergic blocker are simply not good drugs.

ebola

 

[vicapro]

It's my opinion that compounds requiring coadministration of an anxiolytic or adrenergic blocker are simply not good drugs.
ebola

Yes but with this particular class of stimulants (ex. a-pvp, mdpv,) when you first pop your cherry most people dont get the side effects discussed in this thread to such an extent that it would warrent co-administration with some sort of anxioltic or psychoactive chemical that induces effects on the cardiovascular system that helps ease unwanted/agitating heart related responses that this class of psychostimulants is best known for. (at least I didnt until I got to the point where my tolerance to the desired effects got so high that the euphoric rush that lasted 45min in the beginning lasted 5min now after which the unwanted effects lasted much longer unless I took a hit). Of course as most of you know this is the demon aspect of mdpv because while chasing that rush that you only feel for 5min eventually you end up getting symptoms of overdose because the drug is still very much in your blood affecting your central nervous system. This, along with the psychosis can even cause you to think that the mdpv isnt the root cause blaming it on something that while sober would seem so utterly ridiculous causing you to continue. And almost everyone who likes this substance gets to this point eventually and once that happens mdpv and a-pvp will always cause very noticeable anxiety inducing side effects along with only a fraction of the positive dopamine effect it had when you were in the honeymoon phase no matter how much time you take off i. Not to mention that it diminishes the effects of almost every drug after constantly binging on it for a long enough time. And if your at that point where you need a benzo to enjoy the buzz insteead of using it at the end of a binge to sleep its time to just give it up altogether. Honestly I doubt that anyone who has used mdpv and even apvp hasnt looked back at some point and wished they never touched the damn drug.

 

[mister]

would Perindopril Arginine 5mg (Coversyl) be safe and work to lessen the discomfort?

 

[MeDieViL]

I apologise if this has been mentioned as i didnt read the thread.
MDPV chemically wise is considered to be quite safe, however the matter it is being abused can cause detrimental effects indirect to the chemical, just because a chemical is considered safe, we cant conclude abuse of that chemical would be more or less safer then other chemicals.

 

[Jabberwocky]

I'd like to believe that most MDPV deaths in the hands of law enforcement were due to... officer misconduct, not because the drugs actually killed the person. But it's hard to tell. Obviously MDPV can cause heart attacks or strokes in those that are predisposed to it.

pepper spray I've read also causes seizures and muscle contractions when a person is crazed out on PV, believe it has something to do with the rapid fluctuation in blood pressure and like seiko said the tazer induces a further electrical discharge into the already very excited (in a sense body)

MDPV can induce a heart attack at the higest of doses - but they havent been fully documented i believe. much like alpha-pvp. however we're talkinng dosages in the range of grams and mostly IV users. there were reports of PV inducing unconsciousness and leading to hyperthermia too as they passed out hiking in the cold weather. but that perhaps is not a direct result of the PV.

mental damage and scarring seems to be the most prominent issues. perhaps could lead to massive vasoconstriction too.

 

[mister]

MDPV makes me feel incredibly relaxed at times with no apparent change to my heart rhythm?

 

[Kilfer]

It's my opinion that compounds requiring coadministration of an anxiolytic or adrenergic blocker are simply not good drugs.

As you know there is the possibility that a tiny dose of low-potency benzodiazepine, say 2mg diazepam for example, may still display enough adenosine re-uptake activity to reduce discomfort caused by coronary vasoconstriction without triggering any perceivable anxiolytic effects. The matter is currently under empirical investigation

 

[ebola?]

Honestly, at that low a dose, I wouldn't worry that much about benzo dependence. All bets are off if you become tolerant and need to raise the dosage though.

ebola

 

[sekio]

say 2mg diazepam for example, may still display enough adenosine re-uptake activity to reduce discomfort caused by coronary vasoconstriction without triggering any perceivable anxiolytic effects. The matter is currently under empirical investigation

Research done by actual scientists (viz. not dudes taking RCs and benzos and seeing if they feel better) indicates that although benzos are indeed adenosine reuptake inhibitors, they are incredibly weak ones and any potential effect as an adenosine reuptake inhibitor is seriously overshadowed by the effects at the BZD site on GABA-A receptors which happens at 1/1000 to 1/10000 the concentration needed to block adenosine reuptake.

The concentration of diazepam at which the first significant cAMP increase occurs is 10 uM or slightly lower. This is significantly higher than the concentration of diazepam needed to saturate the pharmacologically characterized central nervous system receptors for benzodiazepines.

The effect of diazepam on adenosine uptake and adenosine-stimulated adenylate cyclase in guinea-pig brain

So it's pretty safe to conclude that whatever is happening, it's not an AdRI...

 

[Kilfer]

Indeed some dudes are beginning to doubt that benzos are the best agent for their purposes. But other adenosine RI's are surfacing as we dig a little deeper when we have time.

 

[Stonerhenge]

Doesn't caffeine mess with adenosine?

 

[gavatron@oz]

IMO and experience , it's the mental load that is the most dangerous aspect of MDPV . Physically this drug will lend itself to intense binges wher the body will sustain some sort of normal function far beyond the mind state , mostly due to the overwhelming Ability to almost completely block out any need for food , hydration or sleep. It is usually a black out that will end a hefty binge for those use this very strong stim . I personally have used MDPV for prolonged periods of time , daily use ,and I'm talking 5-6-even 8 month stints only broken by availabilty, this is still ongoing and has been for 21/ 2 years . ive had runs of 5-9 days no sleep , main meal every day , work full time then body would literally shut down , but amazingly with 7-8 hour sleep , body would reset and be full of beans , willing and ready.

Micro sleeps become a major concern, alongside vasoconstriction causing cellulosic which need IV Antibiotics. This is due to the fact you can sit in one place for hours rolled as fuck and avoiding circulation .other pronounces issues are receding gum line / infection and tooth decay,especially if enamel Is damaged already on tooth , also the lack of saliva . Physical twitches slightly at times , especially upon falling asleep . I believe that the majority of side effects are batch specific,And differ amazingly. However the 'jonesing ' Or repetitive OCD behaviour is remarkably uniform in both user and batch, multi tasking without any productivity whilst argumentative and overly inquisitive .

Tolerance can buildup within days, but can also recede in double the time ,cross tolerance with other stims is severe , but once abstinence is seen the effects are once again pleasurable .(for some)

Thos drug isn't for everyone , my example of dependence isn't for anyone at all.


**I DO NOT RECOMMENDED OR IN ANYWAY DEEMED THIS SAFE AT ALL - Im a very experienced stims user and addict (where do they hand out the trophies?) and have had similar issues with daily ongoing use of both meth and coke, the ,MDPV Is financially and physically viable within reason , mentally..... Can get interesting and the intense highs are enjoyable if in comfortable surroundings and somewhat good head space.( I did sub let a part of my mind to the shadow family that taunted me, but even they abandoned residence - think they're scared of me now ...)

Awesome rant-wonder where that tcomes from - take care , I kmow I know - irony

Diazepam is a hypnotic benzo and counteracts the desired affect if taken alprazolam (Xanax)being anti anxiety benzo is much preferably if ever needed. Note : most people would stop use if this is the case but for those that wish to take to counteract negative effects but still use mdpv Then I'd recommend the Xanax. For ending Rolland hopeful sleep , go the Valium (diazepam)

Sorry just realized forum ... Sorry if un informative or overly personal account

 

[mister]

Found it hard to source MDPV so got some crystal A-PVP for my annual indulgence and it feels much more toxic than MDPV, I never go crazy and have binges that last for days but even at small doses vaped it has a definite effect on mood the days following, very irritable and low mood. MDPV on the other hand doesnt seem to have that mood swing effect?

 

[dopamimetic]

Found it hard to source MDPV so got some crystal A-PVP for my annual indulgence and it feels much more toxic than MDPV, I never go crazy and have binges that last for days but even at small doses vaped it has a definite effect on mood the days following, very irritable and low mood. MDPV on the other hand doesnt seem to have that mood swing effect?

This makes me curious, as there are several reports stating the opposite - since I only experienced a-PVP, I can not compare, but thought they would be rather similar.

 

[mister]

This makes me curious, as there are several reports stating the opposite - since I only experienced a-PVP, I can not compare, but thought they would be rather similar.

MDPV and A-PVP are very similar but I find A-PVP makes my head feel cloudy and doesnt have as intense dopamine rush or hornyness of MDPV, they are present but not as pronounced.

 

[RacemicNature]

Well, since now it seems the majority of rc stim-heads have been forced to switch to the next runner up: a-php, the closest in subjective effects to its predecessors. Tho I tend to get more jittery as the dose needed is higher than the others(md pv and a-pvp) and the ratio of physical side effects and stress on the body vs. the subjective high is higher leading to more shakiness and anxious discomfort to reach the desired mind state. From what I've gathered, a beta a blocker, such as clonidine,will help temper the physical stress,but at the price of sacrificing some of the desired effects. I'm going to try an experiment today. I'm on day 2 of a-php use(I did sleep well last night) and I plan on doing some snow shoeing today but I don't want to over work my cardiovascular system. I've read that, by lowering my BP it could actually increase the work load on my heArt, so I'm going to cut the. Lowest clonidine dose in half and add a mg of Ativan and see if that helps eliminate the perphreal side effects and hopefully lessen the load on my heart. I'll update with my results. Also , I was wondering about the possibility of using sildenafil(Viagra ) to control vasoconstriction and heart stress. It produces nitric oxide which dialates parts if the cv system,might this be of use or might it be paradoxical? And help would be appreciated. Thanks

 

[serotonin2A]

Well, since now it seems the majority of rc stim-heads have been forced to switch to the next runner up: a-php, the closest in subjective effects to its predecessors. Tho I tend to get more jittery as the dose needed is higher than the others(md pv and a-pvp) and the ratio of physical side effects and stress on the body vs. the subjective high is higher leading to more shakiness and anxious discomfort to reach the desired mind state. From what I've gathered, a beta a blocker, such as clonidine,will help temper the physical stress,but at the price of sacrificing some of the desired effects. I'm going to try an experiment today. I'm on day 2 of a-php use(I did sleep well last night) and I plan on doing some snow shoeing today but I don't want to over work my cardiovascular system. I've read that, by lowering my BP it could actually increase the work load on my heArt, so I'm going to cut the. Lowest clonidine dose in half and add a mg of Ativan and see if that helps eliminate the perphreal side effects and hopefully lessen the load on my heart. I'll update with my results. Also , I was wondering about the possibility of using sildenafil(Viagra ) to control vasoconstriction and heart stress. It produces nitric oxide which dialates parts if the cv system,might this be of use or might it be paradoxical? And help would be appreciated. Thanks

Just a heads up, but clonidine is not a beta-blocker, it is an alpha2-agonist. Beta-blockers can be dangerous in combination with high doses of stimulants due to the possibility of a hypertensive crisis.

 

[cousinskeeter]

I don't know anything on the physical safety profile of MDPV or a-PVP. But I will say that after 2-3 days of use of each drug, my lungs felt heavier and hurt more than 10 years of cigarettes ever did. The pain and heaviness dissipated about 2 days after stopping usage.

This makes me curious, as there are several reports stating the opposite - since I only experienced a-PVP, I can not compare, but thought they would be rather similar.

Not to derail the topic here but there are varying reports for every single drug ever. I've read that 300ug AL-LAD was crap, and heard that it was mind blowing. I found it mind blowing.

MDPV seems to come on a bit slow, so less of a rush. It also gives me more of a mood life, and much more creativity. It is definitely very more-ish, but only when it wears off. A-PVP is more-ish for the sake of being more-ish. I get zero creativity from a-PVP and hardly any mood lift. Just normal stimulation and the related euphoria. Both make me extremely horny, but I get much less anxiety with MDPV.

I've binged on both, as have many others. Take every report you hear with a grain of salt seriously, even mine.

a-PHP though.... is shit. Sure, technically its the closest to its predecessors, but it sucks ass, not euphoric, not fun. a-PHP is like being allowed to go out to the arcade with your friends when you were a kid, but you sharted yourself on the way there and had to leave the shart remaining in your pants the whole time.

 

[negrogesic]

There is nothing uniquely toxic about MDPV. One should expect that heavy abuse over long enough time periods may result in the typical stimulant toxidrome. Acute dosages will put obvious strain on the heart, liver, kidneys, and could certainly lead to rhabdomyolysis, various failures, etc. As sekio pointed out, there is little SERT involvement here, which could potentially make the compound marginally safer than other compounds (but not necessarily, as it is plenty potent in other respect).

If I recall correctly, MDPV's relative potency to cocaine is something like 50x/10x/.1x (DAT/NET/SERT). I could be wrong in respect my estimate for the SERT, but I doubt 1/10th is far off and I believe that the first two figures are accurate.

The most destructive feature of this drug would generally pertain to the bizarre behaviors and psychological stresses it can induce. Overall, however, it is not the devil incarnate.