MDMA was my first drug at age 20, and boy was it a lovely one. The euphoria generated a whole new meaning of life. Looking for something that came close to that while not doing as much damage, I found meth. Don't get me wrong, it does damage, but not as bad as MDMA as serotonin receptors are way more sensitive. I do one dose on one day on the weekend, have been for about 5 months or so. Usually in the morning after I go to the gym, as it still lasts all day for me. I started off taking it orally, but my preferred ROA is plugging (the two safest ROAs with the longest high and easiest comedown, which I have yet to experience because I eat plenty and drink water on it), 99% bio availability say what! Anyways, I eat extremely healthy especially when I'm high (whole foods, lots of super food vegetables, lots of bananas), stay cool, don't do anything strenuous, and drink plenty of water.
I don't have the urge to do it every weekend, I just do because I have nothing else to do and its a nice escape from reality. If someone made plans or there is a family event or what not, the thought of doing it doesn't cross my mind. I haven't noticed any damage from my by the book use but who knows. If it did start to do noticeable damage (bad mouth, weight loss, inability to work out throughout the week) I would surely give it up in a heart beat. I have never felt the urge to pick at anything or went crazy as I force myself to sleep at night. Hence why I take it in the morning. If you are responsible with it then there is no reason why it can't be less damaging than all the pesticides, stress, or radiated water that pollutes our lives.
Have respect for drugs and they will treat you well. There are things more dangerous than even the most damaging drug. Its all about control and responsibility.