To good to be true is probably the best tag line for MXE. I find it fascinating that even with all my experience with it I still can't be sure if it's positive effects are delusional or not, needless to say I've made a lot of progress with it. It helped me with a seven year marijuana habit that I struggled so hard to deal with. It's been profoundly introspective, and breaks a lot of dogmatic ideas that have built up in my mind, perhaps this is more re-association than dissociation.
Last night I did some ketamine for the first time in several months, was surprised to find a massive cross tolerance, ended up doing half a gram over the evening with very mild effects. To be honest, MXE makes ketamine look very basic indeed. Superficial is a good word. It was a worthwhile experience because I feel I understand the myriad of effects better now. My experience with the dissociatives is becoming more understandable. Had slight back pain in the morning, there must be some benefit to MXE being a smaller dose and thus less toxic metabolites. I did a tiny line of MXE somewhere in the middle of the ketamine dosing and it was nice actually, everything felt very comfortable but it wasn't any near enough to really feel the MXE. I think next time I will do this combo the other way around, or even leave the K all together because for me it's got very little extra to offer... not completely...
I did notice there was an aspect of something that is in K that is not in MXE. I think I'm starting to understand partial activity a lot more now, it seems like there are several systems involved that can become tolerant at different levels... as others have noted if you don't leave big gaps in between MXE doses, IE days/weeks, then you get less of that opiate warm blanket effect and more of the mental lucidity effect. The ability to "hole" with music/mediation disappears with tolerance. I don't think I like the left over effects because they feel very blank and you can't do anything with it. Another thing I noticed doing K is that it is a lot more compulsively addicting than MXE, you find yourself re-dosing like everyone does with K, but now I noticed that it was very empty and almost pointless re-dosing, I don't think I noticed that when I was doing K, when I did a big line I felt good but it passed very quickly and so the value is minimal. This unfortunately could also be viewed as a relative effect, doing stronger and stronger drugs and not being content with lesser effects... this could be a problem, but maybe not. Just some more thoughts on the matter.. but we're reaching some consensus with this I feel.